4-38 DNA Damage in Bone Marrow Mononuclear Cells of Mice Following Total Body Irradiation with Carbon Ions

(整期优先)网络出版时间:2016-01-11
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Amongthemanyspecialfactorsinthespaceenvironment,spaceradiationespeciallyhighenergyheavyionradiationiswidelyregardedasoneofthecrucialfactorsthathazardthehealthandsafetyofastronaut.Itiswellknownthatbiologicaleffectsofradiationaredependentonthelinear-energy-transfer(LET)oftheemergentbeam.HeavyionshavehighLETandcouldinducecomplexandclusteredDNAdamage,whichismoredifficulttoberepairedthaninpiduallesionsandisevenirreparable.