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Study on Liposomes of Mimetic Red Cell

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摘要本项研究从仿红细胞出发，将增加双分子脂膜亲水性的ＰＥＧＰＥ（聚乙二醇与磷脂酰乙醇胺的衍生物）及增加双分子脂膜硬度的ＳＭ（神经鞘磷脂）掺入脂质体，比较其在体外稳定性、体内分布及清除半衰期。结果证明该类脂质体稳定性提高，体内被肝、脾清除减少，血循环中半衰期显著延长。本研究为脂质体载药至非网状内皮系统的靶向给药打下基础。

DOI 54klo0w3jk/1931409

作者侯新朴;仇勇;张俊梅

机构地区不详

出处《中国药学：英文版》 1997年4期

关键词脂质体亲水性修饰硬度修饰

分类 [医药卫生][药学]

出版日期 1997年04月14日（中国期刊网平台首次上网日期，不代表论文的发表时间）

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来源期刊

中国药学：英文版

中国药学：英文版

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相关关键词

脂质体亲水性修饰硬度修饰

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