简介:中国企业界常常存在着一些仅仅需要时间就能证明的悬念。在过去的几十年里,中国的保健品市场出现了太多的叱咤风云的人物和品牌:吴炳新和三株;姜伟和飞龙;骆辉和太阳神;重新站起之前的史玉柱和巨人。不到十年,都败在了时间这个敌人手下。青春宝却一如她产品的广告语“青春宝保青春”,近三十年历经时间的洗礼却稳健增长。青春宝惟一的秘密仅仅是:实在的品质和成效,赢取消费者信赖,形成了一个稳固的消费群体和良好的口碑传播氛围。当然,还有一代又一代的企业家为之默默付出的全部青春。现任青春宝集团董事长的刘俊谦和的说:“现年80岁的冯根生今后还将是青春宝的精神领袖。”而他做的仅仅是传承文化和担当责任。
简介:Oculardrugtransportbarriersposeachallengefordrugdeliverycomprisingtheocularsurfaceepithelium,thetearfilmandinternalbarriersoftheblood-aqueousandblood-retinabarriers.Oculardrugdeliveryefficiencydependsonthebarriersandtheclearancefromthechoroidal,conjunctivalvesselsandlymphatic.Traditionaldrugadministrationreducestheclinicalefficacyespeciallyforpoorwatersolublemoleculesandfortheposteriorsegmentoftheeye.Nanoparticles(NPs)havebeendesignedtoovercomethebarriers,increasethedrugpenetrationatthetargetsiteandprolongthedruglevelsbyfewinternalsofdrugadministrationsinlowerdoseswithoutanytoxicitycomparedtotheconventionaleyedrops.Withtheaidofhighspecificityandmultifunctionality,DNANPscanberesultedinhighertransfectionefficiencyforgenetherapy.NPscouldtargetatcornea,retinaandchoroidbysurficialapplicationsandintravitrealinjection.ThisreviewisconcernedwithrecentfindingsandapplicationsofNPsdrugdeliverysystemsforthetreatmentofdifferenteyediseases.