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简介：摘要人乳头状瘤病毒（HPV）是一种普遍存在的DNA病毒，也是引起子宫颈癌的主要诱因。本文通过介绍HPV的分类、结构、生命周期以及HPV免疫逃逸的生物学机制及研究进展，说明HPV如何通过生命周期进行与宿主DNA的整合以及如何实现免疫逃逸的可能机制。最后，介绍目前针对HPV致瘤机制的相应靶向关键分子作为预防性手段的最新研究，对于针对HPV的科学研究及临床治疗具有一定的参考价值。

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简介：【摘要】目的：探讨HPV分型检测运用在宫颈细胞学阴性HPV阳性妇女中的临床价值。方法：选择2019年2月-2020年2月期间我院收治的190例宫颈细胞学阴性HPV阳性患者为研究对象，均行HPV分型检测，并且根据阴道镜检查结果，对宫颈上皮内瘤变（CIN）Ⅱ+与HPV分型之间的关系。结果：本组的190例患者中，35例为CIN Ⅱ+，占18.42%，其中3例为HPV31型、4例为HPV33型、5例为HPV52型、7例为HPV58型、16例为HPV16型；同时，82例为HPV16型感染，其中55例为宫颈炎症，占67.07%，16例为CIN Ⅱ+型，占19.51%，11例为CIN I型，占13.41%；经相关性分析，与非同型感染患者相比，同型感染者出现病理高级别进展的风险是14.89倍（OR值为2.589，P

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简介：Displacednon-Keplerianorbitsaboveplanetarybodiescanbeachievedbyorientatingthesolarsailnormaltothesunline.ThedynamicalsystemstechniquesareemployedtoanalyzethenonlineardynamicsofadisplacedorbitanddifferenttopologiesofequilibriaareyieldedfromthebasicconfigurationsofHill'sregion,whichhaveasaddlenodebifurcationpointatthedegeneratedcase.Thesolarsailnearhyperbolicordegeneratedequilibriumisquiteunstable.Therefore,acontrollerpreservingHamiltonianstructureispresentedtostabilizethesolarsailnearhyperbolicordegeneratedequilibrium,andtogeneratethestableLissajousorbitsthatstaystableinsidethestabilizingregionofthecontroller.ThemaincontributionofthispaperisthatthecontrollerpreservingHamiltonianstructurenotonlychangestheinstabilityoftheequilibrium,butalsomakesthemodifiedellipticequilibriumbecomeuniqueforthecontrolledsystem.Theallocationlawofthecontrolleronthesail'sattitudeandlightnessnumberisobtained,whichverifiesthatthecontrollerisrealizable.

简介：ObjectivesTostudyclinical,imagingfeaturesandtreatmentoutcomesofcongenitalcholesteatomaofmiddleear(CCME).MethodsThisisaretrospectivereviewof10CCMEcasesselectedfrom952cholesteatomacasestreatedbetweenJanuary1995andDecember2005attheDepartmentofOtolaryngology-HeadandNeckSurgery,ChinesePLAGeneralHospital.Themainoutcomemeasureswerethesiteoforigin,clinicalfeatures,surgicalfindings,imagingcharacteristicsandhearingresults.ResultsThemeanageofthe10patientswas16years(rangedfrom10to24years),with6beingolderthan18years.Therewere7malesand3females.Theaveragedelaytodiagnosiswaslongerthan2years.ThemeanpreoperativePTAwas55dBHL,withameanABGof45dB.Typicalcholesteatomaswereseenbehindthetympanicmembraneinthesuperoposteriorquadrantonotoscopyonlyin2patients.HighresolutionCTwascompletedinallpatients.Mostofthepatients(8/10)werediagnosedwithotosclerosisorossicularabnormalitybeforeoperation.Allpatientsunderwentaone-stagetympanoplastyfollowingtransmeatalexplorativetympanotomyandcompletecholesteatomaremoval,exceptone,whounderwentaCWUmastoidectomyduetoextensivecholesteatomainvolvement.Thecholeasteatomalesionwasconfinedtothesuperoposteriormesotympanuminallpatients.ThemeanpostoperativePTAwas20dBHL.Allpatientswerefollowed-upforatleast1.5yearspostoperatively.Revisionprocedureswereperformedin2patientsforhearingdeterioration.Noresidualorrecurrenceofcholesteatomawasfound.ConclusionCCMEisararediseasethatoftengetsdelayeddiagnosis.Residuallesionsandtheprognosismainlydependontheextentofthelesion.

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简介：Accordingtodifferentiatingsyndromeanddividingpatter,41casesofFacialChloasmabyAuricularPressureinShen(MA-AH),Fei(MA-IC1),Neifenmi(MA-IC3),Luanchao(MA-AT),Mianjia(MA-L)andXia'erbei(MA-IC),thetotaleffectiveratewas87.8%.

简介：摘要BACKGROUNDCoronavirus disease 2019 (COVID-19) caused by a new Betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently a global pandemic. Gathered clinicopathological evidence in COVID-19 patients shows that alveoli injuries and interstitial changes are the major mechanisms of impaired O2/CO2 exchange. Few rehabilitation exercises concerning COVID-19 patients were reported. Here, we present a modified version of rehabilitation exercises based on the underlying mechanism of the disease to mild cases of COVID-19. These exercises aimed to improve the pulmonary function of patients and ease the expectoration process. Additionally, an essential branch of Traditional Chinese Medicine (TCM) named acupressure was integrated into the exercises to facilitate the recovery and maintenance of pulmonary function.METHODSFrom March 4, 2020 to May 5, 2020, a total of 60 COVID-19 patients who completed the full course of MRE were enrolled in this observational study. The diagnostic and classification criteria were based on the 7th edition of Diagnosis and Treatment Guideline of COVID-19 published by the National Health Commission of the People′s Republic of China. We prospectively gathered patients′ reported outcomes concerning respiration-related symptoms at four different time points, including: (I) at admission; (II) at the time of hospital discharge; (III) two weeks after discharge; (IV) four weeks after discharge. The reported respiratory symptoms included dry cough, productive cough, difficulty in expectoration, and dyspnea.RESULTSIn total, 60 confirmed mild COVID-19 cases were enrolled with a median age of 54 years old. The baseline prevalence for dry cough, productive cough, difficulty in expectoration, and dyspnea were 41.7%, 43.3%, 35.0%, and 50.0%, respectively. The pronounced decline in symptom prevalence was recorded over time. Interestingly, four weeks after discharge, we noticed a lower remission rate in productive cough and difficulty in expectoration.CONCLUSIONThe modified rehabilitation exercises were retrieved from the Eight-Section Brocade, and are specifically designed for rehabilitation of COVID-19 patients at home or health facilities. Based on current findings on pronouncedly improved remission rate in respiratory symptoms, we recommend the MRE as suitable rehabilitation exercise to smooth respiration and ease the expectoration process in mild COVID-19 cases.

简介：Leukoplakiavulvaemaybeclassifiedun-derthecategoriesofvulvaitchingandvulvaulcerationintraditionalChinesemedicinewhichholdsthatthediseasesaremostlyasso-ciatedwithexcessivestrainresultingindam-ageofmeridiansandcollaterals,ormentalde-pressionturningintoendogenous″Fire″caus-ingimpairmentofliverandspleenaccompa-

简介：Monoclonalgammopathies被monoclonal的存在描绘在病人与或没有多重骨髓瘤(公里)的证据的免疫球蛋白，macroglobulinemia，淀粉样变性病(AL)，或相关血浆房间proliferative混乱。这研究试图评估实验室monoclonalgammopathies的诊断人物并且调查在monoclonalgammopathies和转变生长因素之间的关联1(TGF1)。Immunofixation电气泳动(IFE)，浆液蛋白质电气泳动(SPE)，用悬液计测量悬液和尿光链ELISA被用于monoclonal免疫球蛋白的实验室鉴定。血浆TGF1与双抗体ELISA被检测。Lightcycler被用于单个核苷酸多型性(SNP)分析。完全，monoclonal免疫球蛋白(M蛋白质)的2,007个案例在10,682件样品被识别。M蛋白质的适应于不同地区生活的动物是IgG类型47.1%，IgA23.0%，IgM8.7%，IgD5.3%，免费的轻链6.1%，9.8%。在IFE的参考，诊断的连贯是浆液光链比率(/)94.4%，Igs83%的quantitation，轻链quantitation80.9%，并且尿光链比率(/)58.0%。血浆TGF1与正常控制相比显著地被提高。codon的突变而产生之遗传的频率10(C>T)也也不没与M蛋白质适应于不同地区生活的动物与M蛋白质的存在被联系。Monoclonalgammopathies能与IFE，SPE，Igsquantitaion和尿的联合被识别光链决心。尽管TGF1，在有免疫力的规定的重要cytokine，在monoclonalgammopathies被提高，在编码TGF1基因的区域的SNP没在这研究授与危险性到monoclonalgammopathies的发展。

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简介：Selectionoftestcasesplaysakeyroleinimprovingtestingefficiency.Black-boxtestingisanimportantwayoftesting,anditsvalidityliesontheselectionoftestcasesinsomesense.Areasonableandeffectivemethodabouttheselectionandgenerationoftestcasesisurgentlyneeded.Thisletterfirstintroducessomeusualmethodsonblack-boxtestcasegeneration,thenproposesanewalgorithmbasedoninterfaceparametersanddiscussesitsproperties,finallyshowstheeffectivenessofthealgorithm.

简介：患者平卧，在腹部分别以双侧天枢穴为中心点作半径为2寸的两个圆，在圆内以分刺法密集针刺，每一圆内施以10～20针，然后接电针，同时针刺双侧阳陵泉、三阴交、太冲、曲池和支沟，治疗印例肥胖患者。以常规针刺法治疗30例为对照。结果两组有效率分别为91．7％和70．0％。

简介：客观：与胸或腹的损害调查polytraumapatients的早诊断和治疗。方法：有胸或腹的损害的所有polytrauma病人的数据回顾地在过去的10年期间被学习。结果:在现在的学习，有1540个polytrauma病人，为所有2368个损伤病人中的65.0%个的财务。这些病人，62.4%处于承认上的吃惊状态。起作用的率是15.0%(181/1206)并且79.9%(612/766)在有胸、腹的损害的病人(P<0.01)，5.2%(39/758)并且31.7%(142/448)在有钝、渗透的胸损伤的病人(P<0.01)，and72.4%(359/496)并且93.7%(253/270)在有钝、渗透的腹的损害(P<0.01)的病人分别地。处理腹的损害，angioembolization在43种情况中被执行，与42治好。全面死亡率是6.2%。并且在钝、渗透的亚群，死亡是7.9%(75/950)并且3.6%(21/590)，分别地(P<0.01)。大多数病人死了fromexsanguination。结论：“在损伤以后的第一个金色的小时”应该被掌握，自从在这个小时的治疗能极大地决定非常伤害的牺牲品是否能幸存。迅速的诊断和合适的治疗比这些更极大地作出贡献到牺牲品的幸存损害的真理。

简介：Inthepresentpaper,176casesoflumbarintervertebraldiscprotrusionaretreatedwithelectroacupuncture(EA)andtopicalheatirradiation.Localtender-pointisusedasthemainacupoint,combinedwithTunzhong,Tiaoyue,Weizhong(BL40)andYanglingquan(GB34).Thetreatmentisconductedoncedaily,with15sessionsbeingatherapeuticcourse.Followingtreatment,of176cases,46(26.1%)arecured,90(51.1%)haveprominentimprovement,35(19.8%)haveameliorationand5(2.8%)havenoapparentchanges,withatotaleffectiverateof97.0%.

简介：1000patientssufferingfromdysmenorrheahavebeentreatedbyapplyingauricular-plastertherapyinourclinicsince1957.Theyweredifferentiatedinto3typesandthengivenpressingtherapyonselectedauricularpoints.Amongthe1000cases,817caseswerecured,markedeffective159cases,withthetotaleffectiverateof99.6%.Thistherapywaseffectivetoall3typesofdysmen-orrhea.