简介:Objective:Theototoxicityofpovidone-iodinehasbeendocumentedinanimalstudies.However,thereislimitedevidenceoftheseototoxiceffectsinhumans.Thisisthefirstreporttoshowtheototoxiceffectsofpovidoneiodineinahumansubject.Patient:A36-year-oldwomancametoourhospitalcomplainingofleftunilateralpersistenthearingloss.Onemonthbeforepresentation,herchildhadaccidentallystruckheronherleftear.Sheappliedapproximatelythreedropsofpovidone-iodine(10%weight/volume)intoherleftauditorycanal.Immediatelyafterapplication,shefeltseverepainandvertigo.Anaudiogramrevealedsevereleftunilateralsensorineuralhearingloss.Magneticresonanceimagingshowedmildenhancementoftheleftvestibuleandbasalturnoftheleftcochlea.Conclusions:Evenasingleapplicationofpovidone-iodinecouldcausesignificanthearinglossanddisequilibrium.Itshould,therefore,beusedwithcaution.
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简介:Inbiosciencepapers,besidestheotherscientificmisconductissues,replicationofthemethodsectionisacommonproblembecauseduplicationisalwaysbeingdetectedinthesectionMaterialsandMethods.Weeditorsoftenreceivecommentsandqueriesfromauthorswhothinkthatitisamatterofcoursetocopytheirownpublishedmaterialsasopposedtocopyingthoseofothers.Howshouldeditorshandlesuchpaperswithsimilarcontentinthemethodsectionandhowtoguideauthorsinwritingthemethodsectionwithoutbeingaccusedofplagiarism?Whatisright?Whatiswrong?Herewestudiedanexampletoexplainthisproblem.
简介:Thispaperconsidersaworst-caseinvestmentoptimizationproblemwithdelayforafundmanagerwhoisinacrash-threatenedfinancialmarket.Drivenbyexistingofcapitalinflow/outflowrelatedtohistoryperformance,weinvestigatetheoptimalinvestmentstrategiesundertheworst-casescenarioandthestochasticcontrolframeworkwithdelay.Thefinancialmarketisassumedtobeeitherinanormalstate(crash-free)orinacrashstate.InthenormalstatethepricesofriskyassetsbehaveasgeometricBrownianmotion,andinthecrashstatethepricesofriskyassetssuddenlydropbyacertainrelativeamount,whichinducestoadroppingofthetotalwealthrelativetothatofcrash-freestate.Weobtaintheordinarydifferentialequationssatisfiedbytheoptimalinvestmentstrategiesandtheoptimalvaluefunctionsunderthepowerandexponentialutilities,respectively.Finally,anumericalsimulationisprovidedtoillustratethesensitivityoftheoptimalstrategieswithrespectivetothemodelparameters.
简介:ADULTMESENCHYMALHAMARTOMAOFTHELIVER:ACASEREPORTWangXianghui王湘辉ChaiFulu柴福录DongLiang董亮LanzhouGeneralHospitalofPLA,Lanzhou730050...