简介：Thispaperreviewsourworkonthefundamentalprinciplesofhighgravitycontrolledprecipitation(HGCP)technology,anditsapplicationsintheproductionofdrugnanoparticles,whichwascarriedoutinarotatingpackedbed(RPB).Severalkindsofdrugnanoparticleswithnarrowparticlesizedistributions(PSDs)weresuccessfullypreparedviaHGCP,includingthe300-nmCefuroximeAxetil(CFA)particles,200–400-nmcephradineparticles,500-nmsalbutamolsulfate(SS)particles(100nminwidth),and850-nmbeclomethasonedipropionate(BDP)particles,etc.Comparedtodrugsavailableinthecurrentmarket,allthedrugnanoparticlesproducedbyHGCPexhibitedadvantagesinbothformulationanddrugdelivery,thusimprovingthebioavailabilityofdrugs.HGCPisessentiallyaplatformtechnologyforthepreparationofpoorlywater-solubledrugnanoparticlesfororalandinjectiondelivery,andofinhalabledrugsforpulmonarydelivery.Consequently,HGCPofferspotentialapplicationsinthepharmaceuticalindustryduetoitscost-effectiveness,efficientprocessingandtheeaseofscaling-up.

简介：RigidFiniteElementMethod(RFEM)wasproposedtosimulatethemechanicalbehaviorofdiscontinuousstructuressuchasrockandsoilstructures.Theauthors’workonthetheoryandapplicationsofRFEMissummarizedinthispaper.BasedonthetheoryofRFEM,theElasticBody-SeamsModel(EBSM)isproposedtotakethedeformationanddamageofrockmassesintoaccount.

简介：Themulti-scalestructuresofcomplexflowsinchemicalengineeringhavebeengreatchallengestothedesignandscalingofsuchsystems,andmulti-scalemodelingisthenaturalwayinresponse.Particlemethods(PMs)areidealconstituentsandpowerfultoolsofmulti-scalemodels,owingtotheirphysicalfidelityandcomputationalsimplicity.Especially,pseudo-particlemodeling(PPM,Ge&Li,1996;Ge&Li,2003)ismostsuitableformolecularscaleflowpredictionandexplorationoftheoriginofmulti-scalestructures;macro-scalePPM(MaPPM,Ge&Li,2001)andsimilarmodelsareadvantageousformeso-scalesimulationsofflowswithcomplexanddynamicdiscontinuity,whilethelatticeBoltzmannmodelismorecompetentforhomogeneousmediaincomplexgeometries;andmeso-scalemethodssuchasdissipativeparticledynamicsareuniquetoolsforcomplexfluidsofuncertainpropertiesorflowswithstrongthermalfluctuations.Allthesemethodsarefavorableforseamlessinterconnectionofmodelsfordifferentscales.However,asPMsarenotoriginallydesignedaseithertoolsforcomplexityorconstituentsofmulti-scalemodels,furtherimprovementsareexpected.PPMisproposedformicroscopicsimulationofparticle-fluidsystemsasacombinationofmoleculardynamics(MD)anddirectsimulationMonte-Carlo(DSMC).ThecollisiondynamicsinPPMisidenticaltothatofhard-sphereMD,sothatmass,momentumandenergyareconservedtomachineaccuracy.However,thecollisiondetectionprocedure,whichismosttime-consuminganddifficulttobeparallelizedforhard-sphereMD,hasbeengreatlysimplifiedtoaprocedureidenticaltothatofsoft-sphereMD.Actually,thephysicalmodelbehindsuchatreatmentisessentiallydifferentfromMDandismoresimilartoDSMC,butanintrinsicdifferenceisthatinDSMCthecollisionsfollowdesignedstatisticalrulesthatarereflectionoftherealphysicalprocessesonlyinverylimitedcasessuchasdilutegas.PPMisidealforexploringthemechanismofcomplexflowsa

简介：介绍了基于GPS、GPRS技术的远程管理终端设备设计方案。采用uC／OS实时操作系统协调各个任务的并行处理；描述了利用LPC系列单片机接收GPS输出定位信息的解析方法；运用CAN总线获取车辆运行和故障信息，并给出了具有抗干扰功能的cAN总线设计电路图；阐述了利用中国移动GPRS公用无线网络，与internet上的服务器进行通讯的实现方法．实践证明，在某型挖掘机上该方案能有效的利用internet远程获取挖掘机的车辆定位信息、运行参数和故障信息，并且采用了多种抗干扰设计，具有更高的可靠性。