简介：Duringthelastfewdecades,photothermalradiometry(PTR)hasbeengreatlydevelopedandwidelyappliedinthefieldofnondestructivetesting.However,thetraditionalPTRsystememploysanexpensivelock-inamplifiertodetecttheweakphotothermalsignal,whichleadstohighcostandlongtesttime.Inthispaper,afasttransmissionPTRsystembasedonsamplingbyusinganinternalcomputersoundcardwasdevelopedtolowerthesystemcostandshorterthetesttime.Apieceofamorphoussilicon(a:Si)thinfilmsolarcellswithartificialdefectswaspreparedandtestedbythesystem.Theresultsshowthatthesharpeneddefectscanbeidentifiedeasilyandquicklyaccordingtothesignificantpeaksoftheoriginalinfraredsignalsampledbytheinternalcomputersoundcard.Furthermore,moredetaileddefectscanbeinvestigatedbyprocessingtheinfraredsignal.ThesevalidatetheeffectivenessoftheproposedtransmissionPTRsystemasalowcostandefficientnon-destructivetesttechnique.

简介：Nowadays,thepassword-basedremoteuserauthenticationmechanismusingsmartcardisoneofthesimplestandconvenientauthenticationwaystoensuresecurecommunicationsoverthepublicnetworkenvironments.Recently,Liuetal.proposedanefficientandsecuresmartcardbasedpasswordauthenticationscheme.However,wefindthatLiuetal.’sschemeisvulnerabletotheoff-linepasswordguessingattackanduserimpersonationattack.Furthermore,italsocannotprovideuseranonymity.Inthispaper,wecryptanalyzeLiuetal.’sschemeandproposeasecurityenhanceduserauthenticationschemetoovercometheaforementionedproblems.Especially,inordertopreservetheuseranonymityandpreventtheguessingattack,weusethedynamicidentitytechnique.Theanalysisshowsthattheproposedschemeismoresecureandefficientthanotherrelatedauthenticationschemes.

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简介：随着商务来往逐渐增多,人们在日常社交场合也都习惯带上自己的名片来认识更多的朋友。虽然不需要再像以前那样随身带个本子记录一堆联系电话及地址,但越来越多的名片却使我们难以进行分类、整理。名片盒与名片夹虽然都有一定优势,但检索起来仍需大量时间,而且对于那些平时不太注意整理名片的人来说,更为查找带来了

简介：Purpose:Acuteexercisehasbeenlinkedtothefacilitationofexecutivefunction,butlittleisknownregardingexecutivefunctionassessedbytheWisconsinCardSortingTest(WCST).ThepresentresearchconsistedoftwoexperimentsaimedtodeterminewhetheracuteaerobicexerciseinfluencessuccessiveWCSTperformance.Methods:InStudy1,27youngadultswererandomlyassignedtotheexerciseorreadingcontrolgroupandtheninstructedtoperformtheWCSTbeforeandafterassignedtreatment.Inexercisegroup,participantscompletedasingleboutaerobicexercisewithmoderateintensityfor20minonastationarybike.AsimilarexperimentalprotocolwasreplicatedinStudy2with24latemiddle-agedadultstolookforagedifferencesduringadulthoodandcontrolforapotentialceilingeffectatyoungadultage.Results:Althoughasignificanttimeeffectwasobservedinyoungadults,bothstudiesrevealedthattherewasnomaineffectfortreatmentoraninteractionbetweentreatmentandtimeonanyoftheWCSTindices.Conclusion:AcuteaerobicexercisefailedtoinfluenceexecutivefunctionasassessedbytheWCST,revealingthatthisclassicalneuropsychologicaltesttappingexecutivefunctionmaynotbesensitivetoacuteexercise.Ourfindingssuggestthatacuteexercisedoesnotbroadlyaffecttheentirefamilyofexecutivefunctions,oritseffectonaspecificaspectofexecutivefunctionmaybetask-dependent,asproposedbyEtnierandChang(2009).

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简介：In2010,Hwang,etal.proposeda'DoS-resistantID-basedpasswordauthenticationschemeusingsmartcards'asanimprovementofKim-Lee-Yoo's'ID-basedpasswordauthenticationscheme'.Inthispaper,wecryptanalyzeHwang,etal.'sschemeandpointoutthattherevealedsessionkeycouldthreatthesecurityofthescheme.Wedemonstratethatextractinginformationfromsmartcardsisequaltoknowingthesessionkey.Thusknownsessionkeyattacksarealsoeffectiveundertheas-sumptionthattheadversarycouldobtaintheinformationstoredinthesmartcards.WeproposedanimprovedschemewithsecurityanalysistoremedytheweaknessesofHwang,etal.'sscheme.Thenewschemedoesnotonlykeepallthemeritsoftheoriginal,butalsoprovidesseveraladditionalphasestoimprovetheflexibility.Finally,theimprovedschemeismoresecure,efficient,practical,andconvenient,becauseellipticcurvecryptosystemisintroduced,theexpensivesmartcardsandsynchronizedclocksystemarereplacedbymobiledevicesandnonces.

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简介：在移动办公日益发展的今天，笔记本已经成为许多人士不可或缺的产品。而随着笔记本的大量普及，越来越多的笔记本用户希望提升笔记本的娱乐功能。最近，赛维数码公司推出的一款专为笔记本电脑设计的SmartTVCard电视卡，通过它，笔记本就成了一台可以随身携带的“高清液晶电视”了。

简介：席卷全球的金融危机给消费电子产业所带来的负面影响是显而易见的，在这样的大背景下，各生产厂商要想火中取栗、逆境求存，仅仅依靠简单的价格战显然远远不够，适应市场变化推出在工业设计及产品功能上都有所突破的新产品才是重中之重。在这方面，海尔无疑是其中做得比较好的，其在11月初推出的新一代开放式流媒体电视——模卡电视（Mo—CardTV）使电视由封闭变成开放，为使用者提供了看电视的新方式。

简介：摘要1例主诉为"腹泻、便血3年"的12岁患儿就诊于西安市儿童医院消化内科，通过肠镜发现肠道黏膜慢性炎症伴糜烂，经病理组织活检确诊为组织胞浆菌病，行胱天蛋白酶募集域蛋白9（CARD9）基因测序提示复合杂合突变。经对症及抗真菌治疗，预后良好。

简介：S系列数码相机是卡西欧轻薄型DC的代表之作，这是从EX—S1就开始确立的产品系列的最大特征。只是让我们感到有些奇怪的是在S系列发展到EX-S12后，型号中的数字部分居然往回走了，推出了最新的EXILIM-CARDEX-S7数码相机。

简介：摘要胱天蛋白酶募集域蛋白9（caspase recruitment domain protein 9，CARD9）是细胞内信号转导的重要衔接蛋白，是非特异性免疫和炎症反应中的关键调节器，并参与抗真菌的免疫反应。近年来发现CARD9基因多态性与克罗恩病（CD）的发病具有相关性。本文就CARD9在CD发病机制中的作用做一综述，为相关研究提供新思路。

简介：AbstractBackground:Real-time polymerase chain reaction (PCR) is a sensitive and specific method for diagnosing schistosomiasis. However, this method should be performed in a laboratory, usually located distant from the sample collection site. Therefore, it is important to have fast sampling preservation methods, which allow simple transport prior to DNA extraction and amplification. The aim of this study was to verify if blood samples applied to filter paper are suitable for analysis of Schistosoma mansoni DNA by real-time PCR.Methods:A cross-sectional study was conducted among 100 study participants aged 17 to 70 years in a fishing village on the southern shore of Lake Victoria, Tanzania. Serum samples and ethylenediaminetetraacetic acid (EDTA)-anticoagulated whole blood for preparation of dried blood spots (DBS) were collected to test for Schistosoma mansoni infection by real-time PCR. A combined diagnostic reference of positive results of serum-based real-time PCR and the Kato-Katz (KK) method was used for analysis. Sensitivity and negative predictive value (NPV) were calculated. The Wilcoxon signed-rank test was chosen to compare the mean cycle threshold (Ct) values from serum and DBS.Results:According to the reference, 92.5% S. mansoni positive samples were determined. The serum-based real-time PCR performed excellently with 95.4% sensitivity, whereas the DBS-based real-time PCR showed a low sensitivity (45.4%). The Ct-values were significantly higher in DBS (median: 37.3) than in serum samples (median: 27.5, P < 0.001), reflecting a lower parasite-specific DNA load on the filter cards. With increasing egg counts, an increase in sensitivity was observed for all methods. The POC-CCA test and the serum-based real-time PCR showed a sensitivity of 100% for medium and severe infections. The DBS real-time PCR showed a sensitivity of only 85.7% even for severe infections.Conclusions:DBS-based real-time PCR did not provide good results in our study and therefore should not be recommended or must be tested concerning temperature of storage, storage duration, use of different filter papers and extraction methods before it is used in future studies. In contrast, our results showed that the POC-CCA test is a sensitive and precise test for detecting S. mansoni infections.

简介：摘要目的探讨胱天蛋白酶募集域蛋白9（CARD9）在C57BL/6小鼠激素抵抗型哮喘气道损伤和炎症中的作用。方法采用随机数字表法，将6~8周龄无特定病原体（SPF）级C57BL/6雌性小鼠分为A组（对照组）、B组（模型组）和C组（地塞米松治疗组），每组6只，B组及C组利用卵清白蛋白（OVA）/完全弗氏佐剂（CFA）腹部皮下注射，OVA雾化激发构建小鼠模型，C组每次致敏前30 min给予地塞米松，末次激发24 h后检测其病理变化及支气管肺泡灌洗液（BALF）细胞计数，进行肺组织炎症浸润情况评分，Western blot检测造模前后CARD9蛋白的变化；然后将雌性6~8周龄C57BL/6野生型小鼠12只和CARD9基因敲除型小鼠12只分为4组，每组6只，其中D组为野生型对照组，E组为野生型模型组，F组为CARD9基因敲除对照组，G组为CARD9基因敲除模型组，造模如上述对照组和模型组。苏木精-伊红染色观察肺组织病理变化，ELISA法检测BALF中白细胞介素（IL）-4、IL-5和IL-17，RT-PCR法检测CXC趋化因子配体10（CXCL-10）和IL-17 mRNA水平。结果B组炎症浸润评分［（3.33±0.82）比（0.67±0.52）分］和BALF总细胞计数［（10.13±4.83）×105个/ml比（3.76±0.84）×105个/ml］均高于A组（均P<0.05）；C组炎症浸润评分［（2.83±0.75）分］和BALF总细胞计数［（9.80±3.19）×105个/ml］与B组差异无统计学意义（P>0.05）；B组CARD9蛋白表达高于A组（0.245±0.090比0.047±0.014，P=0.004）；肺组织病理结果显示，与E组及F组相比，G组的肺组织炎症细胞浸润及组织结构破坏程度加重。与E组及F组相比，G组炎症细胞总数、中性粒细胞数量和嗜酸粒细胞数量均升高（均P<0.05）；IL-4、IL-5及IL-17表达水平均升高（均P<0.05）；支气管肺组织中IL-17及CXCL-10 mRNA表达水平亦均升高（均P<0.05）。结论CARD9基因的缺失可能通过升高IL-17及CXCL-10等中性粒细胞趋化因子，增加中性粒细胞的浸润，从而加重C57BL/6小鼠激素抵抗型哮喘。

简介：1000万像素的数码相机达到极致纤薄的卡话欧EX-S10已于1月下旬正式发售。

简介：目的初步探讨CARD9基因敲除小鼠骨髓来源树突状细胞（bonemarrowderiveddendriticcell,BMDC）对阿萨希毛孢子菌临床株（Trichosporonasahii,T.asahii）的免疫反应缺陷。方法体外培养野生型（wildtype,WT）与CARD9基因敲除型（CARD9knockout,CARD9-/-）小鼠BMDC并分别与热灭活的T.asahii进行共培养,比较两者对菌体的黏附吞噬能力、表面共刺激分子的激活、细胞因子的表达以及两种小鼠感染菌株后的生存率。结果共培养24h后,WT与CARD9-/-小鼠BMDC对T.asahii的黏附吞噬情况比较未见明显差异;经T.asahii刺激的CARD9-/-小鼠BMDC的CD80、CD86激活情况以及白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α表达水平均明显低于WT小鼠BMDC（P〈0.05）;感染T.asahii的CARD9-/-小鼠的生存率明显低于WT小鼠（P〈0.05）。结论CARD9-/-小鼠BMDC对T.asahii的免疫反应缺陷主要体现在共刺激分子的激活以及促炎细胞因子的表达,但并未影响其对T.asahii的吞噬识别。

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