简介：Denovosequencingisoneofthemostpromisingproteomicstechniquesforidentificationofproteinposttranslationmodifications(PTMs)instudyingproteinregulationsandfunctions.WehavedevelopedacomputertoolPRIMEforidentificationofbandyionsintandemmassspectra,akeychallengingproblemindenovosequencing.PRIMEutilizesafeaturethationsofthesameanddifferenttypesfollowdifferentmass-differencedistributionstoseparatebfromyionscorrectly.Wehaveformulatedtheproblemasagraphpartitionproblem.Alinearinteger-programmingalgorithmhasbeenimplementedtosolvethegraphpartitionproblemrigorouslyandefficiently.TheperformanceofPRIMEhasbeendemonstratedonalargeamountofsimulatedtandemmassspectraderivedfromYeastgenomeanditspowerofdetectingPTMshasbeentestedon216simulatedphosphopeptides.
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