简介：Objective:TostudycentralfunctionalnetworkconnectionsandtheiralterationsintinnituspatientsusingfMRI.Methods:Regionalhomogeneity(ReHo)valuesonfMRIwereobtainedfrom18tinnituspatientsand20ageandgender-matchedcontrolsubjects.ReHovalueswerecomparedbetweentinnituspatientsandcontrolsubjectstoevaluatefunctionalnetworkconnectiondifferences.Results:TinnituspatientsshowedincreasedReHovaluesingyrusfrontalisinferioranddecreasedReHovaluesintheanteriorlobeofcerebellumincomparisonwiththecontrols.Analysisoffunctionalnetworkconnectionfromthegyrusfrontalisinteriorshowsstrongerconnectionstothemiddlebrain(FWE,P<0.001)andrightventralstriatum(FEW,P<0.05,smallvolumecorrection).Conclusions:ThefMRIresultsindicatethatbothauditoryandnon-auditorycentersplayimportantrolesintinnitus.Functionalconnectionsamongtheauditorycortex,thalamus,medialtemporalgyrus,parahippocampalgyrusandinsulamaybeanunderlyingcauseforthedevelopmentoftinnitus.