简介:1995年Yoshida等描述了有自身免疫性表现的慢性胰腺炎的临床、实验室和组织学特征,提出了自身免疫性胰腺炎(autoimmunepanereatitis,AIP)或自身免疫相关性胰腺炎(autoimmune—relatedpancreatitis)这一概念。AIP是慢性胰腺炎的特殊类型,其病理学上表现为胰腺明显的淋巴细胞浸润并有胰腺的纤维化,导致胰腺功能障碍,故也称为淋巴浆细胞硬化性胰腺炎(1ymphoplasmaeyticsclerosingpanereatitis)。虽然此疾病是由多种不同的病因构成的,但是目前AIP这一名称仍然被广泛地接受。
简介:摘要:目的:研究对于自身免疫性肝病(ALDS)患者诊断中肝抗原自身抗体检测价值分析。方法:于我院不同ALDS患者中各随机抽取30例,统计患者自身抗体检测结果,回顾性对比各组的自身抗体阳性率。结果:PBC患者检出AMA-M2阳性26例(86.67%),SP100阳性6例(20.00%),gp210阳性7例(23.33%),均高于其他患者。AIH患者检出SLA阳性3例(10.00%),LKM-1阳性5例(16.67%),LC-1阳性3例(10.00%),均高于其他患者。组间对比差异显著(P<0.05)。PSC患者各抗体阳性率并无明显差异(P>0.05)。结论:患有PBC的患者检出AMA-M2、SP100、gp210阳性率更高,AIH患者检出SLA、LKM-1、LC-1阳性率更高,应用自身抗体检测具有一定指导意义,帮助临床辨别疾病类型。
简介: 摘要:目的 分析自身抗體在自身免疫性肝炎和乙型病毒性肝炎中的特征。方法 选取 2018 年 3 月~ 2019 年 3 月在我院诊治的 50 例自身免疫性肝炎( AIH 组)患者和 54 例乙型病毒性肝炎( HBV 组)患者为研究对象,并选取同期 50 例体检健康者为对照组,比较三组阳性检出率及血清中自身抗体指标 [ (抗平滑肌抗体( SMA )、抗核抗体( ANA )、抗肝肾微粒体抗体( LKM-1 )、抗肝细胞胞质抗体Ⅰ型( LC-1 )、抗线粒体抗体Ⅱ型( AMA-M2 )、可溶性肝抗原 / 肝胰抗原( SLA/LP ) ] 。结果 AIH 组 ANA 阳性检出率均高于 HBV 组和对照组( P<0.05 ) ; HBV 组 ANA 以 1∶100 低滴度为主,以核匀质、核颗粒型为主, AIH 组以 1∶320 、 1∶1000 的高滴度为主,以核颗粒型为主,也可见核匀质和核膜型 ;AIH 组 SMA 、 LKM-1 、 SLA/LP 阳性检出率高于 HBV 组和对照组( P<0.05 ), LC-1 、 AMA-M2 与 HBV 组和对照组比较,差异无统计学意义( P>0.05 )。结论 自身免疫性肝炎患者血清中含有高滴度自身抗体,乙型病毒性肝炎含有低滴度自身抗体,且自身免疫性肝炎患者血清中 SMA 、 LKM-1 、 SLA/LP 抗体阳性率相对较高,通过检测自身抗体水平,有助于肝炎的诊断和治疗。 关键词:自身抗体 ; 自身免疫性肝炎 ; 乙型病毒性肝炎 ; 临床特征 Abstract : Objective To analyze the characteristics of autoantibodies in autoimmune hepatitis and viral hepatitis B. Methods 50 patients with autoimmune hepatitis ( AIH group ) and 54 patients with viral hepatitis B ( HBV group ) diagnosed and treated in our hospital from March 2018 to March 2019 were selected as the research subjects , and 50 cases of health examination during the same period were selected. The control group was compared with the autoantibody indicators in the three groups [ ( anti-smooth muscle antibody ( SMA ), anti-nuclear antibody ( ANA ), anti-hepatorenal microsomal antibody ( LKM-1 ), and anti-hepatocyte cytoplasmic antibody type I ( LC-1 ), anti-mitochondrial antibody type II ( AMA-M2 ), soluble liver antigen / hepatic pancreatic antigen ( SLA/LP ) ].Results The ANA positive detection rate in AIH group was higher than that in HBV group and control group ( P<0.05 ) ; ANA in HBV group was mainly with a low titer of 1 : 100. Mainly , the AIH group was dominated by high titers of 1 : 320 and 1 : 1000 , and the nuclear granule type was the main type. The homogeneous nuclear and nuclear membrane types were also seen; the AIH group was positive for SMA , LKM-1 , and SLA / LP the rates were higher than those in the HBV group and the control group ( P<0.05 ) . Compared with the HBV group and the control group , LC-1 and AMA-M2 had no significant difference ( P>0.05 ) .Conclusion Serum of patients with autoimmune hepatitis contains high-titer autoantibodies , hepatitis B virus contains low-titer autoantibodies , and the positive rates of SMA , LKM-1 , SLA / LP antibodies in serum of patients with autoimmune hepatitis are relatively high. By detecting the level of autoantibodies , it is helpful for the diagnosis and treatment of hepatitis.