简介:T房间激活是在仅仅通过这个过程后来开始适应有免疫力的反应的一个批评过程特定的T房间区分进调停的武装受动器T房间的na(i)ve抗原实际有免疫力的response.DuringT房间激活,na(i)veT房间经历同种细胞的扩大并且获得能力杀死感染病原体的目标房间或生产为调整有免疫力的反应必要的cytokines。T房间的不恰当的激活或inactivation导致autoimmunity或严重免疫不全。PKC-有选择地在T房间被表示并且为调停要求了T房间激活过程。在PKC-缺乏的老鼠在T房间激活,幸存和activation-inducedcell死亡展出缺点。PKC-有选择地translocates到免疫学的触处并且调停为为T房间activation.Furthermore是必要的NF-B,AP1和NFAT的激活要求的信号,PKC--/-鼠标在vivo在T调停房间的有免疫力的回答的开发显示了多重缺点。PKC-因此是在vivo在T调停房间的有免疫力的回答在多重阶段调整T房间功能的一个批评分子。细胞与分子的免疫学。2006;3(4):263-270。
简介:干癣是hyperproliferativekeratinocytes和T房间,树枝状的房间,巨噬细胞和neutrophils的渗入描绘的最普通的调停免疫者的长期的、煽动性的皮肤病之一。尽管干癣的致病充分没被理解,有宽大的证据,建议在皮肤的有免疫力的房间的dysregulation,特别地T房间,在干癣开发起一个关键作用。在这评论,我们主要集中于病原的T房间并且讨论这些T房间怎么被激活并且在疾病致病包含了。最新识别的‘;professional’;IL-17-producing真皮的γ;δ;在干癣的T房间和他们的潜在的角色将也被包括。最后,我们将简短为干癣处理在T房间和它的相关指向cytokine的治疗上总结最近的进步。
简介:Traditionally,thematerialswhichareregardedasantigensrecognizedbyγδTlymphocytesareproteinandcarbohydrate,notnucleicacidorlipid.Recently,ithasbeendemonstratedthatγδTcellscanrecognizelipidAanddirectlyinduceimmuneresponsesthatinvolveCD1(clusterofdifferentiationtype1)familyandTolllikereceptors(TLRs).Thisisareviewabouttheinteracting-mechanism,immunologicaleffectandclinicalapplicationofthem.Cellular&MolecularImmunology.
简介:摘要目的讨论CT平扫与X射线平片技术在鼻骨骨折诊断中的优势。方法现随机选取2015年4月-2016年12月我院收治的确诊为鼻骨骨折患者102例作为研究对象,分成实验组51例和对照组51例,实验组给予CT平扫技术进行诊断,对照组患者采取X射线平片技术进行诊断。对两组患者在鼻骨骨折的诊断中的准确性进行分析和评价。结果实验组患者采用CT平扫技术诊断后发现51例患者均被诊断为鼻骨骨折,诊断的有效率为100%,其中被诊断为单纯鼻骨骨折患者有23例、鼻中隔骨折患者有13例、复合鼻骨骨折患者有15例,诊断符合率达到100%。对照组患者采用X射线平片技术发现51例患者中有22例患者为鼻骨骨折,有12例为可疑鼻骨骨折和12例未发现鼻骨骨折,诊断的有效率为43.1%;被诊断为单纯鼻骨骨折患者有13例、鼻中隔骨折患者有6例、复合鼻骨骨折患者有3例,诊断符合率分别为56.5%,46.1%,20.0%。结论CT检查技术在鼻骨骨折的临床诊断的准确性上优于X射线平片技术,对鼻骨骨折的具体位置以及骨折类型和骨折程度都有很高的准确性。
简介:摘要目的去除眼眶周围的蓝色、褐色、黑色、青黑色或混合色色素斑。方法调Q激光去除太田痣。结果32例患者选择了调Q激光治疗,疗效好,患者很满意。结论用Q激光治疗太田痣,其疗效好,安全性高,值得临床推广应用。
简介:摘要目的分析探讨喹硫平与奥氮平治疗老年痴呆患者精神行为障碍的应用效果。方法选取2010年2月-2013年6月在我院神经内科就诊的老年痴呆患者86例,将其按照年龄、性别、病情等情况随机对照组和试验组,每组患者43例。对照组患者采用喹硫平药物治疗,试验组患者采用奥氮平药物治疗。对两组患者分别治疗8周。在治疗前、治疗2周、治疗4周和8周后,分别采用痴呆病理行为评定量表(BEHAVE-AD)评定治疗效果,采用简易精神状况量表(MMSE)评定患者痴呆情况,采用日常生活能力量表(ADL)评定患者的生活质量。结果治疗2周后,试验组患者的痴呆病理行为评定量表评分较对照组患者显著下降。试验组患者治疗前后简易精神状况量表评分无显著差异,对照组患者治疗8周后简易精神状况量表显著升高。两组患者的比较具有统计学意义(P<0.05)。讨论喹硫平与奥氮平对治疗老年痴呆都具有较好疗效,奥氮平效果较喹硫平快,而且疗效显著。
简介:Activation-inducedcelldeath(AICD),whichresultsfromtheinteractionbetweenFasandFasligand,isresponsibleformaintainingtolerancetoself-antigen.AdefectinAICDmayleadtodevelopmentofautoimmunity.Duringthelastseveralyears,muchprogresshasbeenmadeinunderstandingthemechanism(s)ofAICDanditspotentialroleinthepathogenesisofautoimmunediseases.Inthisreview,wesummarizethemostrecentprogressontheregulationofthesusceptibilityofTcellstoAICDanditspossibleinvolvementinautoimmunediseases.
简介:Itiswell-knownthatidiopathicthrombocytopenicpurpura(ITP)isanacquiredorgan-specificautoimmunehemorrhagicdiseaseanddysfunctionalcellularimmunityisconsideredimportantinthepathophysiologyofITP.However,polarizationpatternsandapoptosisprofilesofTlymphocytesremainunclear.Inthisstudy,weinvestigatedthepolarizationofTcellsubsets,theexpressionsofapoptoticproteinsFas/FasLonthesubsetsandthelevelofanti-apoptoticgenebcl-2andbaxmRNA.ItwasdemonstratedthattheratiosofTh1/Th2andTc1/Tc2inITPchildrenwereincreasedobviouslyandthattheaveragepercentageswereincreasedclearlyforTh1andTh2,butnotforTc1andTc2.InITPchildren,theenhancingexpressionsweredetectedforFasLonTh1andTc1andforFasonTh2andTc2.Withincreasinglevelofbcl-2mRNAanddecreasingexpressionofbaxmRNAinITPchildren,theratioofbcl-2/baxmRNAwasimprovedobviously,whichwaspositivecorrelatedwiththeratioofTh1/Th2.Takentogether,ourfindingsindicatethatITPisaTh1predominantdisease.ThispolarizationpatternofTcellsubsetsmightberelatedtothehighratioofbcl-2/baxmRNAandtheabnormalexpressionsofFasandFasLonTcellsubsets.Cellular&MolecularImmunology.
简介:IncreasedexpressionofFasbyhematopoieticprogenitorsinaplasticanemia(AA)suggeststhatFas/Fasligand(FasL)systemplaysakeyroleintheformationofseverepancytopenia.Tofurtherconfirmtheabovehypothesis,Tcellsfrom8patientswithAAweresystematicallystudiedfortheirFasL'sdistributionpattern,releasingmannerandproapoptoticactivity,comparedwithnormalrestingTcellsandartificiallyactivatedTcellblasts.TheresultsdemonstratedthatAATcellsabnormallyexpressedlowlevelsofmembrane-boundFasLandcontainedhighlevelsofintracellularFasLwhichcouldbetriggeredtoreleasebyhigh-dosephytohemagglutinin(PHA)pulse-stimulation.ThesupernatantsfromthePHA-stimulatedAATcellshadapparentcytotoxicityagainstFasL-sensitiveJurkatcells,whichcouldbesignificantlyinhibitedbymonoclonalantibodyagainstFasLinadose-dependentmanner,ornearlycompletelyabrogatedbyultracentrifugation.TheabovephenomenaalsoappearedonartificiallyactivatedTcellblasts,butthiswasnotthecaseonnormalrestingTcells.TheseresultsindicatethatAATcellisatypeof'preactivated'Tlymphocyte,characterizedbyoverexpressionofFasL,especiallyintracellularFasLwhichcanbestimulatedtoreleaseinbioavtiveexosomesboundform.Takentogether,ourdataprovidefurtheranddirectevidenceforthehypothesisthatTcellsmightmediatethedestructionofhematopieticprogenitorinAAthroughFas/FasLsystem.