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简介：AIM:Toevaluatetheefficacyandsafetyofcornealcollagencrosslinking(CXL)topreventtheprogressionofpost-laserinsitukeratomileusis(LASIK)cornealectasia.·METHODS:Inaprospective,nonrandomized,single-centrestudy,CXLwasperformedin20eyesof11patientswhohadLASIKformyopicastigmatismandsubsequentlydevelopedkeratectasia.Theprocedureincludedinstillationof0.1%riboflavin-20%dextranesolution30minutesbeforeUVAirradiationandevery5minutesforanadditional30minutesduringirradiation.Theeyeswereevaluatedpreoperativelyandat1-,3-,6-,and12-monthintervals.Thecompleteophthalmologicexaminationcompriseduncorrectedvisualacuity,bestspectacle-correctedvisualacuity,endothelialcellcount,ultrasoundpachymetry,cornealtopography,andinvivoconfocalmicroscopy.·RESULTS:CXLappearedtostabiliseorpartiallyreversetheprogressionofpost-LASIKcornealectasiawithoutapparentcomplicationinourcohort.UCVAandBCVAimprovementswerestatisticallysignificant(P<0.05)beyond12monthsaftersurgery(improvementof0.07and0.13logMARat1year,respectively).Meanbaselineflattestmeridiankeratometryandmeansteepestmeridiankeratometryreduction(improvementof2.00and1.50diopters(D),respectively)werestatisticallysignificant(P<0.05)at12monthspostoperatively.At1yearafterCXL,meanendothelialcellcountdidnotdeteriorate.Meanthinnestcorneapachymetryincreasedsignificantly.·CONCLUSION:Theresultsofthestudyshowedalong-termstabilityofpost-LASIKcornealectasiaaftercrosslinkingwithoutrelevantsideeffects.Itseemstobeasafeandpromisingproceduretostoptheprogressionofpost-LASIKkeratectasia,therebyavoidingordelayingkeratoplasty.

简介：<正>DearSir,IamDr.HuijaeLee,fromtheSeoulIreEyeClinic,Seoul,Korea.Iwritetopresentacasereportofesotropiaafterocclusiontherapy.Amblyopiacanbecausedby

简介：Choroidalneovascularization(CNV)isanuncommoncomplicationassociatedwithamacularhole.Inthiscasereportofararecondition,wepresentapathologicmyopiapatientwithaco-existentmacularholeandchoroidalneovascularmembrane.ThepatientwastreatedwithphotodynamictherapyforCNV,andthenvitreoussurgeryfortheretinaldetachmentandmacularhole.Attheendof4yearsfollow-up,hervisualacuitywasimprovedto0.1whilethemacularholeremainedopen.OpticalcoherencetomographyisausefulinspectionmethodofthediagnosisofCNVandmacularhole.

简介：AIM:Tocomparethetrabecularmeshwork(TM)andirisapoptosisoftreatedanduntreatedprimaryopenangleglaucoma(POAG)patients.METHODS:Eighttreatment-naive,newlydiagnosed(group1)and11medlcaiytreated(group2)patientswithPOAGwereincludedinthestudy.Eachpatientunderwentalimbus-basedtrabeculectomy.TheTMandperipheralirisspecimensweredissectedoutandweresnap-frozeninliquidnitrogenandstoredat-80tuntiltheywereassayed.ApoptosisineachgroupwasassesedbyTUNELmethod.RESULTS:Themeanpatientagewas60.6±5.8years(53-68years)vs58.9±8.9years(47-70years)ingroup1andgroup2(P=0.859).Themeantreatmenttimeingroup2was22.2±7.3months(12-34months).ApoptoticindexesinTMandirisweresignificantlyhigherinPOAGpatientsusingmedication(group2)comparedtotreatment-naivePOAGpatients(group1)(P=0.004,0.015;respectively).CONCLUSION:LongtermadministrationoftopicalantiglaucomamedicationscausesadditionaltoxiceffectsonTM.

简介：AIM:Toinvestigatetheantifibroticeffectofthefreeze-driedbilayeredfibrin-bindingamnioticmembraneasadrugdeliverysystemonglaucomasurgeryinrabbitmodel.Theaimofthisstudywastoprepareanovellocaldeliverysystemforthesustainedandcontrollablereleaseof5-Fu.METHODS:Twenty-fourJapanesewhiterabbitswererandomizedintothreegroups:theexperimentalgroup(oculartrabeculectomyincombinationwith5-Fuloadedfreeze-driedbilayeredfibrin-bindingamnioticmembranetransplantation),thecontrolgroup(oculartrabeculectomyincombinationwith5-Fu)andtheblankgroup(singletrabeculectomy).HEstaining,massionstainingandimmunohistochemistryforα-SMAwereperformedondays7,14,21and30followingsurgery.Theconcentrationof5-Fuinrabbitaqueoushumorwasexaminedbyhighperformanceliquidchromatography(HPLC)3daysafterthesurgery.RESULTS:Statisticaldifferenceswerenotedinintraocularpressureamonggroupsonday7,14,21and30followingsurgery.Histologyfurtherdemonstratedthattrabeculectomyincombinationwithfreeze-driedbilayeredfibrin-bindingamnioticmembraneyieldedwellwoundhealingandnoscarformationandwasbeneficialforlongtermeffect.CONCLUSION:HPLCshowedagoodslow-releaseeffectwithfreeze-driedbilayeredfibrin-bindingamnioticmembrane.

简介：AIM:Todeterminethehistopathologicalchangesofrifampicinappliedintravitreallyonretinalganglioncellsbymeansofstereologicalandhistopathologicalmethods.METHODS:Forthisstudytwenty-fourNewZealandadultrabbitsweredividedintofourgroups(n=6foreachgroup).50μg/0.1mL(group1),100μg/0.1mL(group2),150μg/0.1mL(group3)and200μg/0.1mL(group4),rifampicinwereinjectedintothevitreousoftherighteyesofanimals,theirlefteyeswereusedascontrol(group5).Afterthe28thdayofapplication,animalswereanesthetisedwithxylazine(8mg/kg,IM)andthentheireyeswereenucleatedimmediately.Patternsweretakenawayandeyeswerepreparedforbothstereologicalandelectromicroscopicobservation.RESULTS:Dependingonthehighdoseofrifampicin,somehistopathologicalchangessuchascytoplasmicdilatationanddamagedmembranewereobservedontheelectromicroscopiclevel.Usingquantitativeexamination,whichwasdoneatthelightmicroscopiclevel,itwasshownthatthenumberofneuronsdecreasedlinearlyasrifampicindoseincreasedwhencomparedwiththecontrolgroup.CONCLUSION:Basedonthesefindings,low-doserifampicin(50μg/0.1mL)maybeusefulfortreatmentoftheoculardiseases.

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简介：摘要本文主要对妊娠高血压综合征患者的预防和治疗进行探讨和分析，主要分为妊娠高血压综合征的早期诊断、妊娠高血压综合征的预防和和妊娠高血压综合征的治疗三个方面，以期能够为临床预防和治疗提供一定的借鉴。

简介：【摘要】目的：探讨孟鲁司特治疗儿童慢性咳嗽的效果。方法：选取 50例慢性咳嗽患儿，均为 2018年 1月至 2020年 1月期间收治，按照随机数字表法分为两组，对照组（ n=25）采用常规治疗，观察组（ n=25）采用孟鲁司特治疗，分析肺功能指标、咳嗽缓解时间、咳嗽完全消失时间及不良反应发生率。结果：观察组咳嗽缓解时间、咳嗽完全消失时间及不良反应发生率较对照组低，肺功能指标较对照组高， P＜ 0.05。结论：对儿童慢性咳嗽采用孟鲁司特治疗效果较好，可有效缓解咳嗽症状，改善患儿肺功能，降低不良反应发生率。

简介：不运动关节长时间伏案工作会导致关节总是处于同一角度，相对被固定的状态。如果再加上驼背等不良身姿，更会加剧肌肉的松弛。

简介：摘要目的分析在服用卡马西平后引起的重症药疹的治疗方案以及临床效果。方法从我院在2011年5月至2015年7月收治的238例因药疹住院的患者中选取16例服用卡马西平引起的重症药疹的患者，收集16例患者的临床资料，并对其进行分析。结果在这16例患者中，重症多形红斑有6人，大疱性表皮松解症有8例，剥脱性皮炎型有2例；卡马西平重症药疹的病势较严重，且病情发展较快，采用糖皮质激素治疗效果较好，这16例患者均治愈出院。结论卡马西平重症药疹会导致多器官功能紊乱，且发病急、病情重、发展快、病程长，在临床上大多采用糖皮质激素治疗，合理运用糖皮质激素，才是治疗成功与否的关键，在临床上应该慎用卡马西平。

简介：<正>DearSir,IamDr.Zhong-ShanChenfromtheDepartmentofOphthalmology,WuhanGeneralHospitalofGuangzhouMilitaryCommand,HubeiProvince,China.Iwritetopresenttwocaseswithserpiginouschoroiditis(SC)whichisarare,usuallybilateral,chronic,progressiveinflammationofthechoroid,choriocapillarisandretinalpigmentepithelium.InthispaperwepresentedthedifferentoutcomesofSCpatientswithorwithoutsystemicandoculartreatmentsafterlong-termfollow-up.

简介：摘要血样标本采集和患者准备会影响实验室分析结果，并成为实验室质量控制的重要环节。为探讨血液标本的正确采集方法，根据自己多年来的经验，并参考有关资料分别从采集前准备，采血部位与方法，采血时间，采血容器，采集前的注意事项，血液标本的处理等细节及相应预防措施进行阐述，并为实验室提供合格的，高质量的标本提供参考。

简介：摘要目前，物联网、大数据、云计算等信息技术的迅速发展，智慧教育很好的实现了信息技术和教学深度结合，带动了应用型本科的教学的可持续发展。应用型本科思维能力的培养一直是教学的目标。智慧教育下的思维教学对学生思维能力的提高超过了日常的教学界限，又融合在日常的学科教学活动之中。因此，面向智慧教育的思维教学以学生为主的教学起点，突破传统按不同科目进行的教学设计局限，从而培养学生的批判性思维、创造性思维等等。面向智慧教育的思维教学的要建立在综合分析学生的学习特征和个性基础上。智慧教学的思维教学要把学习的主动权给学生，这样才能为应用型本科培养出色的智慧学习人才。

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简介：摘要目的总结良好的备皮方法，降低术后切口感染率。方法针对不同的手术部位，采用六种不同的备皮方法，观察术后切口愈合情况。结果不同的备皮方法切口愈合的情况不同。结论针对不同手术部位，采取良好的相应备皮方法，能将术后切口感染几率降到最低。

简介：应用Navier-Stokes方程和质量连续原理对具有锥度角的动脉血管中非定常状态下的血液发展流动建立了一组数学模型,采用贝塞尔函数方法进行了解析求解,获得了非定常状态下的动脉血液发展流动的速度分布和压力分布公式.并与定常状态下动脉血管中的血液发展流动做了比较.结果表明,非定常状态下动脉血液发展流动的压力分布和定常状态下的动脉血管中的血液发展流动的压力分布差别很大.

简介：AIM:Totestthehypothesisthatamblyopicneuroretinamayhaveanalteredthicknesswhencomparedtothenormal.·METHODS:Twenty-fiveamblyopic,youngpatientsbetweentheagesof7and11yearsoldwerestudied.Theinterestedneuroretinaareasaredefinedinto10sub-regionsaccordingtosuperior-inferior,nasal-temoral,andperi-paraaxis,whichcrossthefovelastructure.Thethicknessesoften,definedmacularregionswereseparatelymeasuredbyopticalcoherencetomography(OCT)andanalyzedbyt-test.·RESULTS:Theaveragethicknessofneuroretinaintheexactfoveolaoftheamblyopiceyesislargerthanthatofnormaleyes(P<0.05),buttheothernineregionshavenosignificantdifference.Interestingly,inboththenormalandamblyopiceyes,thetemporalarealooksthinnerthanotherquadrants(P<0.05).·CONCLUSION:Thicknessalterationmaybeassociatedwithamblyopicdisordersinyoungpatients.Studyingalargervolumeofsubjectsofsimilarageisrequiredtoconfirmthisobservation.