简介：目的探讨全视网膜冷凝联合睫状体冷冻术治疗晚期新生血管性青光眼的疗效。方法对2011年1月到2013年2月间在我院住院的18例18眼晚期新生血管性青光眼患者使用全视网膜冷凝加睫状体冷冻术治疗的临床资料进行回顾性分析。结果所有患者出院后随访12-15月,15眼眼压控制正常,虹膜表面新生血管消退,成功率达83%。2眼术后眼压在31-34mmHg,给予贝特舒眼药水后眼压控制正常。1眼术后眼压大于35mmHg,一月后给予第2次冷冻治疗,术后眼压控制正常。结论全视网膜冷凝联合睫状体冷冻治疗晚期新生血管性青光眼不仅是一种简单、经济、而且是一种控制晚期新生血管性青光眼的眼压,解除患者临床症状的有效方法。

简介：<正>DearSir,IamDr.Zhong-ShanChenfromtheDepartmentofOphthalmology,WuhanGeneralHospitalofGuangzhouMilitaryCommand,HubeiProvince,China.Iwritetopresenttwocaseswithserpiginouschoroiditis(SC)whichisarare,usuallybilateral,chronic,progressiveinflammationofthechoroid,choriocapillarisandretinalpigmentepithelium.InthispaperwepresentedthedifferentoutcomesofSCpatientswithorwithoutsystemicandoculartreatmentsafterlong-termfollow-up.

简介：AIM:Totestthehypothesisthatamblyopicneuroretinamayhaveanalteredthicknesswhencomparedtothenormal.·METHODS:Twenty-fiveamblyopic,youngpatientsbetweentheagesof7and11yearsoldwerestudied.Theinterestedneuroretinaareasaredefinedinto10sub-regionsaccordingtosuperior-inferior,nasal-temoral,andperi-paraaxis,whichcrossthefovelastructure.Thethicknessesoften,definedmacularregionswereseparatelymeasuredbyopticalcoherencetomography(OCT)andanalyzedbyt-test.·RESULTS:Theaveragethicknessofneuroretinaintheexactfoveolaoftheamblyopiceyesislargerthanthatofnormaleyes(P<0.05),buttheothernineregionshavenosignificantdifference.Interestingly,inboththenormalandamblyopiceyes,thetemporalarealooksthinnerthanotherquadrants(P<0.05).·CONCLUSION:Thicknessalterationmaybeassociatedwithamblyopicdisordersinyoungpatients.Studyingalargervolumeofsubjectsofsimilarageisrequiredtoconfirmthisobservation.

简介：<正>DearSir,IamProf.BeuyJoobfromSanitation1MedicalAcademicCenter,Bangkok,Thailand.Iwritetodiscusstherecentpublicationonproteomicanalysisindiabeticretinopathy(DR).Liuetal[1]concludedthattheirapproachbytwodimensionalfluorescencedifferencegelelectrophoresis(2D-DIGE)combinedwithmatrix-assistedlaser

简介：近视性屈光不正已成为眼科最常见的疾病之一,且发病率呈逐年上升趋势,其中高度近视是常见的致盲病因。一般认为近视的发生、发展是由基因遗传和环境因素共同作用的结果。目前对近视的治疗和预防的方法主要包括光学矫正、药物干预和手术干预。如何通过有效的预防方法来降低近视的患病率是当今眼科领域研究的热点和难点。

简介：目的：观察翼状胬肉切除联合角膜缘干细胞移植及术后药物治疗翼状胬肉的临床疗效。方法：共行翼状胬肉切除联合角膜缘干细胞移植术治疗的翼状胬肉患者760例980眼。选取亚复发期的162例162眼进行观察,随机分为A,B两组,A组滴1g/L丝裂霉素C＋诺氟沙星滴眼液1～3mo;B组交替滴地塞米松滴眼液、双氯芬酸钠滴眼液1～3mo。结果：A组痊愈67眼（81.7%）,亚复发12眼（14.6%）,复发3眼（3.7%）。B组痊愈35眼（43.8%）,亚复发29眼（36.3%）,复发16眼（20.0%）。A组复发率明显低于B组（P〈0.01）。结论：翼状胬肉切除联合自体角膜缘干细胞移植术,无排斥反应、安全有效、术后复发率低,术后给予滴眼液后续治疗尤为重要,更能有效地抑制和降低翼状胬肉术后的复发率,能明显提高治疗效果。

简介：患者，男57岁因左眼内侧渐起赘片十年余于2006年9月23日就诊我院。眼部检查：两眼视力0．8，左眼鼻侧球结膜呈翼状增厚，浸入角巩缘内4mm，头部较宽，附着部角膜灰白色混浊，

简介：1病例报告患者黄xx,男,40岁,工人。1mo前在工作中切割金属时感一异物飞溅入左眼,当即左眼灼热感、眼红伴流泪,无胀痛、畏光,无头昏、头痛、恶心、呕吐等症状,未引起重视,后自觉左眼视力下降,视物模糊,到当地医院治疗（具体治疗不详）,症状无明显缓解。左眼视力进一步下降,遂来我院就诊,门诊诊拟＂左眼角膜穿通伤,深层角膜异物？＂收住入院。入院查：视力：OS0.25,OD1.0,

简介：肾脏疾病引起高血压称为肾性高血压，是继发性（症状性）高血压中最为常见的一类。肾性高血压性视网膜病变，一般是先就诊内科而后转眼科会诊检查眼底时发现，首诊到眼科的少见，且容易误诊。现将在门诊遇到的1例患者介绍如下。

简介：0引言急性后部多灶性鳞状色素上皮病变（acuteposteriormultifocalplacoidpigmentepitheliopathy,APMPPE）由Gass于1968年首先报道。本病发病急,目前临床并不多见。本文报道1例双眼急性后部多灶性鳞状色素上皮病变的病例,就其发病原因、病情演变及治疗、愈后进行简要的分析总结。

简介：AIM:Toinvestigatethepossiblerelationshipbetweentheinfluencingfactorsoccurringbeforeandduringbirthinfull-terminfantsandtheoutcomeofretinopathy.·METHODS:Totally816full-terminfantsadmittedintheneonateintensiveunitofBoaiHospitalofZhongshanbetween1May,2008and30June,2011wereincludedinthestudy.Fundusexaminationwasperformedandevaluatedindividuallyonthemattheageof48hoursafterdelivery,2weeksand1month.Somepossibleriskfactorshappeningprenatallyorduringdeliverysuchaspregnantrelatedhypertension,placentaprevia,placentalabruptionetc,aswellassomeneonatalriskfactorssuchasneonatalasphyxia,hypoxic-ischemicencephalopathy(HIE),lowbirthweightetc,wererecordedandevacuated.Thentheeffectoftheriskfactorsoffull-terminfantsonretinopathywasstudied.·RESULTS:Theincidenceofretinalhemorrhageoffull-terminfantswithprenatalpregnantrelatedhypertension(PRH)ofthemother(43.6%)wassignificantlyhigherthanthatoffull-terminfantswithout(8.0%).(P<0.001).Theincidenceofretinalhemorrhageoffull-terminfantswithneonatalasphyxiaand/orhypoxic-ischemicencephalopathy(HIE)(29.3%)wassignificantlyhigherthanthatofthosewithout(15.7%),butcorrelationwasnotfoundbetweentheseverityofretinahemorrhageandthedegreeofhypoxicdisease.Apalecolorofopticdiscwasassociatedwithalowbirthweightoffull-terminfant.Full-terminfantswithbirthweighlessthan2500ghadasignificanthigherincidenceofretinopathythanthosewithbirthweightequalormorethan2500g(P<0.001).·CONCLUSION:Themaininfluencingfactorswhichleadtoretinopathyofhighriskfull-terminfantsareprenatalfactorssuchasPRH,andsomeneonatalriskfactorssuchasasphyxia,hypoxic-ischemicencephalopathy,andlowbirthweight.

简介：AIM:Tocharacterizetheclinicalfeatures,diagnosis,treatmentandprognosisofuveitisassociatedwithankylosingspondylitis(AS)inChinesepatients.·METHODS:TwohundredandthreepatientswithuveitisassociatedwithASfollowed-upintheThirdMilitaryMedicalUniversityDapingHospitalbetween2005and2010wereretrospectivelyevaluatedinthisstudy.Completeophthalmologicalexaminationswereevaluatedatbaselineandduringthefollow-upperiod.Thegender,age,follow-uptime,meanfrequencyofuveitisonset,andaccompanyingeyeexaminationfindings,history,demographicalparameterswerereviewed.Allthepatientspresentedcompleteclinicalandradiologic(sacroiliac,lumbar,dorsalandcervicalspine,knee,ankle,shoulder,hip,elbow)evaluation.HLA-B27typingwasalsosearched.·RESULTS:Therewere203patientsdiagnosedwithASassociateduveitis.AllshowedsacroiliacX-raychangesindicativeofAS.Therewere184maleand19femalepatients.Theaverageageofpatientswas35±12(range18-50).Meanfollow-upperiodwas2.4years(1-5years).Acuteanterioruveitiswasthemostcommontypeofuveitisinbothgenders.121eyespresentedunilateralinvolvement(55.2%),and92eyespresentedbilateralinvolvement(45.3%)withonsetalternately.22eyesoccurredhypopyon,16eyeswerefoundanteriorvitreouscells,7eyeswerenotedreactivemacularedemaorexudation,29eyespresentedposteriorsynechiaeofiris,and14eyespresentedcataract,9eyespresentedsecondaryglaucoma,2eyespresentedbendcornealdegenerationand1eyespresentedatrophyofeyeball.Atthefinalvisit,uveitiswaswellcontrolledinmostpatients.·CONCLUSION:ASassociatedwithuveitisinChinesepatientsmainlymanifestsasacuteanterioruveitis.AcombinationofcorticosteroidswithothermydriasisagentsiseffectiveformostASassociatedwithuveitispatients.Ingeneral,theprognosisisgoodinthesecases.

简介：AIM:Tofindouttheoutcomeoflaserphotocoagulationinclinicallysignificantmacularedema(CSME)byopticalcoherencetomography(OCT).·METHODS:Itwasaprospective,non-controlled,caseseriesstudyenrolling81eyesof64patientswithCSMEbetweenAugust2008andJanuary2010.AllpatientsreceivedmodifiedgridphotocoagulationwithfrequencydoubledNd:YAGlaser.Eachpatientwasevaluatedintermsofbest-correctedvisualacuity(BCVA)andregressionorprogressionofmaculopathyafterlasertherapyat1,3and6months.Spearman’scorrelationtestwasusedtoshowthecorrelationbetweenBCVAandtotalmacularvolume(TMV).Analysisofvariance(ANOVA)wasusedtocompareamonggroupsandindependentt-testwasusedtocompareineachgroup.·RESULTS:ThereishighcorrelationbetweenBCVAandTMV(P≤0.001).BCVAimprovedin50.6%,remainedstaticin39.5%anddeterioratedin9.9%patientsafter6monthoftreatment.TheBaselineTMV(meanandSD)were9.26±1.83,10.4±2.38,11.5±3.05,8.89±0.75and9.47±1.98mm3fordifferentOCTpatterns,ST(spongelikethickening),CMO(cystoidmacularedema),SFD(subfovealdetachment),VMIA(Vitreomacularinterfaceabnormality)andaverageTMVrespectively(P=0.04).After6monthsoflasertreatment,themeanTMVdecreasedfrom9.47±1.98mm3to8.77±1.31mm3(P=0.01).InSTtherewassignificantdecreaseinTMV,P=0.01,Furtherwithinthesegroupsat6months,theyweresignificantlydifferent,P=0.01.·CONCLUSION:OCTshowedthedifferentmorphologicalvariantofCSMEwhiletheresponseoftreatmentisdifferent.TMVdecreasedthemostandhenceshowedtheimprovementinvisionafter6monthsoflasertreatment.IntheeraofAntivascularendothelialgrowthfactors(VEGFs),efficacyoflaserseemstobeinshadowbutitisstillfirstlineoftreatmentindevelopingnationlikeNepalwhereantiVEGFsmaynotbeeasilyavailableandaffordable.

简介：Simulationcanbedefinedasmalingering,orsometimesfunctionalvisualloss(FVL).Itmanifestsaseithersimulatinganophthalmicdisease(positivesimulation),ordenialofophthalmicdisease(negativesimulation).Consciousbehaviorandcompensationorindemnityclaimsareprominentfeaturesofsimulation.Sincesomeauthorssuggestthatthisisamanifestationofunderlyingpsychopathology,evenconversionisincludedinthiscontext.Intoday’sworld,everyophthalmologistcanfacewithsimulationofophthalmicdiseaseordisorder.Incaseofsimulationsuspect,thephysician’sresponsibilityistoprovethesimulationconsideringthedisease/disorderfirst,andsimulationasanexclusion.Insimulationexaminations,thephysicianshouldbefirmandsmarttoselectappropriatetest(s)toconvincenotonlythesubject,butalsothejudgeincaseofindemnityorcompensationtrials.Almostallophthalmicsensoryandmotorfunctionsincludingvisualacuity,visualfield,colorvisionandnightvisioncanbethesubjectofsimulation.Examinermustbeskillfulinselectingthemostappropriatetest.Apartfromthoseintheliterature,weincludedallkindsofsimulationinophthalmology.Inaddition,simulationexaminationtechniques,suchas,useofOCT(opticalcoherencetomography),frequencydoublingperimetry(FDP),andmodifiedpolarizationtestswerealsoincluded.Inthisreview,wemadeathoroughliteraturesearch,andaddedourexperiencestogivethereadersup-to-dateinformationonmalingeringorsimulationinophthalmology.

简介：AIM:ToinvestigatetheroleofRho-associatedproteinkinase(ROCK)inhibitor,Y27632,inmediatingtheproductionofextracellularmatrix(ECM)componentsincludingfibronectin,matrixmetallo-proteinase-2(MMP-2)andtypeIcollagenasinducedbyconnectivetissuegrowthfactor(CTGF)ortransforminggrowthfactor-β(TGF-β)inahumanretinalpigmentepithelialcellline,ARPE-19.METHODS:TheeffectofY27632ontheCTGForTGF-βinducedphenotypeinARPE-19cellswasmeasuredwithimmunocytochemistryasthechangeinF-actin.ARPE-19cellsweretreatedwithCTGF(1,10,100ng/mL)andTGF-β(10ng/mL)inserumfreemedia,andanalyzedforfibronectin,laminin,andMMP-2andtypeIcollagenbyRT-qPCRandimmunocytochemistry.CellswerealsopretreatedwithanROCKinhibitor,Y27632,toanalyzethesignalingcontributingtoECMproduction.·RESULTS:TreatmentofARPE-19cellsinculturewithTGF-βorCTGFinducedanECMchangefromacobblestonemorphologytoamoreelongatedswirlpatternindicatingamesenchymalphenotype.RT-qPCRanalysisanddifferentgeneexpressionanalysisdemonstratedanupregulationinexpressionofgenesassociatedwithcytoskeletalstructureandmotility.CTGForTGF-βsignificantlyincreasedexpressionoffibronectinmRNA(P=0.006,P=0.003respectively),lamininmRNA(P=0.006,P=0.005),MMP-2mRNA(P=0.006,P=0.001),COL1A1mRNA(P=0.001,P=0.001),COL1A2mRNA(P=0.001,P=0.001).PreincubationofARPE-19withY27632(10mmol/L)significantlypreventedCTGForTGF-βinducedfibronectin(P=0.005,P=0.003respectively),MMP-2(P=0.003,P=0.002),COL1A1(P=0.006,P=0.003),andCOL1A2(P=0.006,P=0.004)geneexpression,butnotlaminin(P=0.375,P=0.516).CONCLUSION:OurstudydemonstratedthatbothTGF-βandCTGFupregulatetheexpressionofECMcomponentsincludingfibronectin,laminin,MMP-2andtypeIcollagenbyactivatingtheRhoA/ROCKsignalingpathway.Duringthisprocess,ARPE-19cellswereshowntochangefromanepithelialtoamesenchymalphenotypeinvi

简介：目的为了寻求安全、简便、经济、有效治疗结膜松弛症的方法，评价结膜松弛症结膜新月形切除术的临床疗效。方法采用前瞻性研究方法，对结膜松弛症患者15例（30眼）行结膜新月形切除术。术后第2、4、8周随访患者症状改善程度，裂隙灯观察结膜松弛切除程度、手术切口愈合情况、手术并发症评价、测量泪河、泪膜破裂时间及氯霉素眼液尝味试验。结果术后4周国际眼表面疾病指数明显降低，术后8周趋于稳定，与术前比较，差异有统计学意义（t=6．743，P=0．000）。术后2、4、8周泪河明显改善，术后8周25眼泪河恢复正常。术后8周泪膜破裂时间≥10s有18眼，与术前比较差异有统计学意义（X^2=8．297，P=0．004）。术后8周，氯霉素眼液尝味试验阳性率为46．6％（14／30）。松弛结膜残留积分术后2周10分，4周7分，8周6分。手术并发症积分术后2周6分，4周12分，8周8分。结论球结膜新月形切除术治疗结膜松弛症安全、有效，明显改善结膜松弛症症状。

简介：病毒性角膜炎是一种常见的眼病，通俗来说就是眼睛感染了病毒引起的炎症。病毒性角膜炎所引起的症状主要包括眼痛、流泪、眼睛发红、视力模糊等。一旦出现这些症状，就需要及时去医院看病，进行治疗。但是即使治愈了病毒性角膜炎，也有些人会面临后遗症的问题。 病毒性角膜炎最常见的后遗症是视力模糊和干眼症及角膜的瘢痕。角膜是眼睛的透明组织，是视觉的主要传导介质，如果受到损伤，就会导致不同程度的视力下降。大多数情况下，角膜瘢痕会对视力产生很大的影响，甚至可能导致失明。下面将具体科普一下病毒性角膜炎后遗症及具体治疗方法及注意事项。

简介：AIM:Toevaluatetheaccuracyofsphericalequivalent(SE)estimatesofadouble-passsystemandtocompareitwithretinoscopy,subjectiverefractionandatablemountedautorefractor.METHODS:Non-cycloplegicrefractionwasperformedon125eyesof65healthyadults(age23.5±3.0years)fromOctober2010toJanuary2011usingretinoscopy,subjectiverefraction,autorefraction(AutokeratorefractometerTOPCONKR-8100,Japan)andadoublepasssystem(OpticalQualityAnalysisSystem,OQAS,VisiometricsS.L.,Spain).Nineconsecutivemeasurementswiththedouble-passsystemwereperformedonasubgroupof22eyestoassessrepeatability.ToevaluatethetruenessoftheOQASinstrument,theSElaboratorybiasbetweenthedoublepasssystemandtheothertechniqueswascalculated.RESULTS:TheSEmeancoefficientofrepeatabilityobtainedwas0.22D.SignificantcorrelationscouldbeestablishedbetweentheOQASandtheSEobtainedwithretinoscopy(r=0.956,P<0.001),subjectiverefraction(r=0.955,P<0.001)andautorefraction(r=0.957,P<0.001).ThedifferencesinSEbetweenthedouble-passsystemandtheothertechniquesweresignificant(P<0.001),butlackedclinicalrelevanceexceptforretinoscopy;Retinoscopygavemorehyperopicvaluesthanthedouble-passsystem-0.51±0.50Daswellasthesubjectiverefraction-0.23±0.50D;Moremyopicvalueswereachievedbymeansofautorefraction0.24±0.49D.CONCLUSION:Thedouble-passsystemprovidesaccurateandreliableestimatesoftheSEthatcanbeusedforclinicalstudies.Thistechniquecandeterminethecorrectfocuspositiontoassesstheocularopticalquality.However,ithasarelativelysmallmeasuringrangeincomparisonwithautorefractors(-8.00to+5.00D),andrequirespriorinformationontherefractivestateofthepatient.

简介：患儿,女,4岁.转移性胸痛、耳痛、腿痛2年入院.2年前患儿出现左侧胸痛及肿块,1个月后症状自行消失.1年半前出现右耳道溢血脓、听力下降、眩晕、耳痛等症状,后症状逐渐消失,但听力下降无明显改善,当时CT检查发现右侧颞骨岩部出现边缘光整的骨质缺损,内耳结构不清(图①、②).

简介：病例介绍患者男38岁,因＂右眼义眼台1期植入术后5年暴露1年＂入院。病程中在外院三次行右眼义眼台暴露结膜切口对位缝合术、羊膜修补术及唇黏膜修补术,结果均失败。体检：右眼睑无红肿,右眼义眼台暴露约6mm×8mm,周围球结膜轻度充血,表面少量粘性物覆盖,眼台运动基本正常,余未见明显异常。完善各项检查后拟局麻下行义眼台暴露自体中薄皮瓣移植修复术。