简介:Thequestforneuroprotectivedrugstoslowtheprogressionofneurodegenerativediseases(NDDs),includingAlzheimer'sdisease(AD),Parkinson'sdisease(PD),andHuntington'sdisease(HD),hasbeenlargelyunrewarding.Preclinicalevidencesuggeststhatrepurposingquetiapine,lithium,valproate,fluoxetine,donepezil,andmemantineforearlyandpre-symptomaticdisease-modificationinNDDsmaybepromisingandcanspareregulatorybarriers.Theliteratureofthesepsychotropicsinearlystageandpre-symptomaticAD,PD,andHDisreviewedandpropitiousfindingsfollow.Mildcognitiveimpairment(MCI)phaseofAD:salutaryhumanrandomizedcontrolledtrialfindingsforlow-doselithiumand,inselectedpatients,donepezilawaitreplication.Pre-symptomaticAD:humanepidemiologicaldataindicatethatlithiumreducesADrisk.Animalmodelstudies(AMS)revealencouragingresultsforquetiapine,lithium,donepezil,andmemantine.EarlyPD:valproateAMSfindingsshowpromise.Pre-symptomaticPD:lithiumandvalproateAMSfindingsareencouraging.EarlyHD:uncontrolledclinicaldataindicatenon-progressionwithlithium,fluoxetine,donepezil,andmemantine.Pre-symptomaticHD:lithiumandvalproateareauspiciousinAMS.Manyotherpromisingfindingsawaitingreplication(valproateinMCI;lithium,valproate,fluoxetineinpre-symptomaticAD;lithiuminearlyPD;lithium,valproate,fluoxetineinpre-symptomaticPD;donepezilinearlyHD;lithium,fluoxetine,memantineinpre-symptomaticHD)arereviewed.Dose-andstage-dependenteffectsareconsidered.Suggestionsforsignal-enhancementinhumantrialsareprovidedforeachNDDstage.
简介:电气化铁路牵引变电所27.5kV高压室内空间狭小、带电设备较多,是改造的难点。通过具体工程实例,介绍移动高压室在三相V,v牵引变电所27.5kV高压室改造中的应用。针对三相V,v牵引变电所进线、馈线数量较多,27.5kV侧母线布置复杂的特点,提出了移动高压室采用A相、B相馈线分体组装方案。并对过渡方案进行整体介绍。
简介:Thispaperconstructedportfoliosaccordingtothegrowthratesandtheirstabilityoffirm'stotalstockholders'equitypershareandnetincomepershare,usingallthefirms'informationofShanghaiA-sharemarket.Wefoundthatthemarketexhibitssomeoverreactiontothegrowthraieoffirm'snetincomepershare,andisn'tsensitivetothestabilityoffirm'sgrowthrates.
简介:TheU.S.-drivenTPPhascaughttheattentionoftheregionandisbringinguncertaintytoEastAsianeconomicintegration.China,theU.S.andJapanhavetakendifferentpositionsontheTPPitself.TheU.S.isactivelyparticipatinginTPPnegotiationsandtryingtodominateit.JapanregardstheTPPasatoolwithwhichitcanfurtherexploremarketsaswellasstrengthenitsrelationshipwiththeU.S..ChinaiscurrentlyassessingtheU.S.shiftineconomicstrategytowardsEastAsiaandthepotentialimpactsofTPPexpansion.
简介:NatsumeSōseki(1867-1916)sufferedfromcyclicmentaldepressionsthroughhislife,anditwaswhenhewasinthestateofthemostterribleonethathestartedhiscareerasawriterbywritingIAmaCat(1905-1906).TherearesomeevidencebyhiswifeandfriendsthatSōseki’sconditionofdiseasedramaticallyimprovedduringitsserializationonamagazine,andthewriterhimselfadmitedhumorouslyintheprefaceofotherworkthatitwashisdepressionandmaniathatenabledhimtoproduceIAmaCatandotherearlyworks.Thispaperaimsatdescribingtheprocesshowhisactofnarratinghadtherapeuticeffectsonhisstateofmindfocusingontheconstructionofcomplicitousrelationshipbetweenanimpliedauthorandreadersintheworkbytheuniquefunctionsofthefirst-‘person’narrator:ACat.Amongothers,IwillconsidertheinfluenceofLaurenceSterne’sTristramShandy(1759-1767),whichSōsekiintroducedtoJapanforthefirsttime,bydiscussingthefrequentuseofmetalepsisthatthetwoworkshaveincommon.
简介:学校变革是教育改革的突破口与落脚点。大学与中小学在政府的支持保障或促成下进行合作的U-G-S模式具有重要意义,然而其局限也很明显:投入多、见效慢,理论研究者与实践者交流不畅。U-G-S-S模式承继了U-G-S模式的优势,并进行了突破:强调参与学校变革行动的中小学的数量为两所及以上,且学校教育质量是异质的,既有城市优质学校,也有城郊薄弱学校或乡村学校;U-G-S-S四方主体平等互动、各司其职。个案研究表明,U-G-S-S模式可以通过制度建构、任务驱动和文化营造促进各参与学校的整体发展,促进城乡义务教育均衡发展。U-G-S-S模式成功的三个主要要素:文化异质交融、知识多维共享、理论实践有机结合。
简介:Rotation in Reaction 19F+51VRotationinReaction19F+51V¥WangQi;LuJun;XuHushan;LiSonglin;ZhuYongtaiandZhangYuhuIndLssi...