简介：无

简介：无

简介：精子chromatin/DNA正直为父亲的基因信息的精确传播是必要的，并且正常精子染色质结构为使肥沃的精子是重要的能力。精液的常规检查，包括精子集中，活动性和形态学，不在精子染色质结构识别缺点。为它的评价的精子DNA损坏和许多方法的起源被描述。精子DNA损坏的评估看起来是为估计男富饶潜力的一个有用工具在活体内和在试管内。后代上的精子DNA缺点的可能的影响也被讨论。

简介：Fermentedfoodshavebeenconsumedforcenturiesacrossmanygeographicallocalesandhavetraditionallybeenconsideredhealthyfoods,partlybecauseofthelivemicrobescontainedinthem.Theconceptof'probiotics'furtherrequiresthatthemicrobesbedefinedandtheirhealtheffectsbedemonstratedthroughhumaninterventionstudiesorothersuitableinvestigationsbeforemarketingwithcorrespondinghealthmessages.Here,wereviewrecommendationsforfermentedfoodsandprobioticsinseveralcountriesoutsidetheEU,focusingonfood-baseddietaryguidelines.Weemphasizerecommendationsonyoghurtandprobioticsmadebyexpertbodies.Wefoundthatdietaryguidelinescommonlyadvocatetheconsumptionofyoghurtorsimilarproducts,butspecificcommentsonprobioticsarerare.Further,wereviewedguidelinesfromclinicalassociations.Ingeneral,theyacknowledgethebeneficialeffectsofprobiotics,butoftensuggesttheneedforfurtherresearch.Thisistruedespitegoodqualityevidencesupportingtheroleofprobioticsforcertainhealtheffects,suchaspreventionofeczemaininfants,managementofsideeffectsfromantibioticsandalleviationoffunctionalbowelsymptoms.Additionalresearchtosupportfuturedietaryrecommendationsshouldfocusondeterminingeffectsize,identifyingrespondersandnon-responders,clarifyingstrain-specificityofeffectsandconfirmingmechanisms.

简介：AbstractGastric cancer (GC) is one of the most common malignant tumors. The mechanism of how GC develops is vague, and therapies are inefficient. The function of microRNAs (miRNAs) in tumorigenesis has attracted the attention from many scientists. During the development of GC, miRNAs function in the regulation of different phenotypes, such as proliferation, apoptosis, invasion and metastasis, drug sensitivity and resistance, and stem-cell-like properties. MiRNAs were evaluated for use in diagnostic and prognostic predictions and exhibited considerable accuracy. Although many problems exist for the application of therapy, current studies showed the antitumor effects of miRNAs. This paper reviews recent advances in miRNA mechanisms in the development of GC and the potential use of miRNAs in the diagnosis and treatment of GC.

简介：

简介：客观：在乳癌学习P-glycoprotein(P-gp)的临床的意义。方法：在乳癌的60种情况中的P-gp的表示被immunohistochemistry检验。到化疗的P-gp表示和反应比较地与变形乳癌在19个病人被调查。结果：P-gp在乳癌的60个案例中的48.3%个中是积极的。P-gp表示不与病人的年龄，月经地位，包含的腋的淋巴节点的数字，临床的阶段，组织学的类型，和神经质的受体地位有关(P>0.05)。转移(62.1%)和死亡(51.7%)的频率比在否定情况中在P-gp积极案例中是更高的(16.1%对12.9%，P<0.005)。P-gp积极案例(48.3%)的5年的幸存率比否定案例(87.1%)的显著地低(P<0.05)。在收到了辅助化疗的病人，远转移比在P-gp否定案例(57.1%)(P=0.0468)中更经常发生在P-gp积极案例(94.7%)中。更多的P-gp否定病人(7/9)对化疗(P=0.0055)比积极病人(1/10)应答。结论：P-gp表示的Immunohistochemical检查在在乳癌病人预言反应到化疗和预后是有用的。P-gp确实与差的预后被联系。

简介：无

简介：Themyelodysplastic/myeloproliferativeneoplasms(MDS/MPNs)areauniquegroupofhematologicmalignanciescharacterizedbyconcomitantmyelodysplasticandmyeloproliferativefeatures.Accordingtothe2008WHOclassification,thecategoryincludesatypicalchronicmyeloidleukemia(aCML),chronicmyelomonocyticleukemia(CMML),juvenilemyelomonocyticleukemia(JMML),MDS/MPN-unclassifiable(MDS/MPN-U),andtheprovisionalentityrefractoryanemiawithringsideroblastsandthrombocytosis(RARS-T).Althoughdiagnosiscurrentlyremainsbasedonclinicopathologicfeatures,theincorporationofnextgenerationplatformshasallowedfortherecentmolecularcharacterizationofthesediseaseswhichhasrevealeduniqueandcomplexmutationalprofilesthatsupporttheirdistinctbiologyandisanticipatedtosoonplayanintegralroleindiagnosis,prognostication,andtreatment.Futuregoalsofresearchshouldincludethedevelopmentofdisease-modifyingtherapies,andfurthergeneticunderstandingofthecategorywilllikelyformthefoundationoftheseefforts.

简介：Thisthesishasfurtherstudiedthelowresistanceofmeridianpointswithanewin-strumentcalledModelTZ-03ofresistancedetectorforAcupoints.Throughexperimentsandclinicalobservation,theauthorfoundthatthechangesofskinresistancesofpointsarecloselyrelatedtothechangesofhumanphysiologyandpathology.Theexperimentsalsoshowthatthefactorswhichinflu-encetheresultsarecomplicatedandchangeableinmanyways.Therefore,theabsolutevaluesoftheresistancesofpointsarenotpreciseandstahlefandtheratiooftheresistanceofbilateralpointofthesamenameismorere1iable.Inhealthypeople,theresistancesofthesarnepointsontwosidesofthebodyaresimilar,andthereismuchdifferenceoftheseresistancesamongpeoplewithdiseases.

简介：

简介：Leukoplakiavulvaemaybeclassifiedun-derthecategoriesofvulvaitchingandvulvaulcerationintraditionalChinesemedicinewhichholdsthatthediseasesaremostlyasso-ciatedwithexcessivestrainresultingindam-ageofmeridiansandcollaterals,ormentalde-pressionturningintoendogenous″Fire″caus-ingimpairmentofliverandspleenaccompa-

简介：AbstractBackground:It is a challenge to characterize the consciousness level of patients with severe disturbance of consciousness and predict their prognosis effectively for Chinese doctors. We aimed to investigate the psychometric property and the diagnostic practicality of severe disturbance of consciousness by Chinese Nanjing persistent vegetative state scale (CNPVSS) which was first set up in 1996 and modified in 2001 and 2011.Methods:The concurrent validity, inter-rater consistency and diagnostic accuracy of CNPVSS and Chinese version of coma recovery scale-revised (CRS-R) were investigated by assessment of 380 patients with severe disorders of consciousness.Results:Total scores of the CNPVSS were correlated significantly with that of the CRS-R, indicating acceptable concurrent validity. Sub-scale analysis showed moderate to high inter-rater reliability and test-retest reliability. CNPVSS was superior to CRS-R on the diagnosis sensitivity. The CNPVSS was able to distinguish 65 patients in emergence from minimal consciousness state who were misclassified as in minimal consciousness state (MCS) by the CRS-R, and it could also distinguish two patients in MCS who were misclassified as in vegetative state by the CRS-R.Conclusion:The CNPVSS is an appropriate measurement and is sensitive to distinguish the MCS patients from the VS patients.

简介：KONGRao-qi,male.bornin1944.Wasajuniorconsultantdoctor,astandingmemberandthedcputysecretary-generalofZhejiangProvincialAcupuncturcAssociation.thedirectorofZhejiangscalp-acupointcommittee,tichasbccnengagedinacupuncturepracticeformorethan30years.Withgreatattainmentsinthescalpacupuncture.Heishighlyskilledattheacupuncturetreatmentofapoplecticsequelae,

简介：AbstractBackground:Mallet fracture is avulsion of the terminal extensor tendon from the base of the distal phalangeal bone with a bony fragment. This study was performed to evaluate the anatomical characteristics of mallet fractures, investigate a new mallet fracture classification system using anatomical and imaging methods, and discuss the treatment schemes for different types of mallet fracture.Methods:Sixty-four fresh cadaveric fingers were divided into four groups, and models of different types of mallet fracture with distal interphalangeal joint instability were established by dissecting 25%, 50%, 75%, and 100% of the bilateral collateral ligaments. The effect of mallet fractures on the stability of the distal interphalangeal joint was then observed. The lateral radiographs of mallet fractures in 168 patients were analyzed and classified according to the involvement of the joint surface in the fracture, the thickness of fracture, the untreated time after injury, and the complication of distal interphalangeal joint palmar subluxation. Forty-seven patients were surgically treated by reconstruction of extensor tendon insertion, the Ishiguro method, or single Kirschner wire fixation.Results:The established mallet fracture model showed that the distal interphalangeal joint was stable when the bilateral collateral ligaments were cut off by 25% (t= -0.415, P = 0.684) and significantly unstable when this range was ≥50% (50% transection: t= -6.363, P < 0.001; 75% transection: t= -17.036, P < 0.001; 100% transection: t = -30.977, P < 0.001, respectively). The mallet fractures were divided into Types I, II, and III (fracture involving <20%, 20%-50%, and >50% of the joint surface, respectively). Type II was further divided into Types IIa and IIb according to whether the course of injury was < or ≥2 weeks, respectively. The mean post-operative flexion of the distal interphalangeal joint was 63.4° ± 7.9°, and the mean extension lag was 6.7°± 4.6°.Conclusions:The lateral collateral ligament is the main factor that maintains the stability of the distal interphalangeal joint. Classification that combines the involvement of the joint surface in the fracture, the thickness of the fracture, and the untreated time after injury is reasonable and will help to choose an appropriate operational method.

简介：

简介：无

简介：Inflammatorydemyelinatingpseudotumorusuallyoccursinthebrainandrarelyoccursinthespinalcord.Onimaging,inflammatorydemyelinatingpseudotumorappearsverysimilartointramedullarytumorssuchasgliomas.Itisoftenmisdiagnosedasintramedullarytumorandsurgicallyresected.Inviewofthis,theclinicalandmagneticresonanceimagingmanifestationsandthepathologicalfeaturesof36casesofinflammatorydemyelinatingpseudotumorinthespinalcordwereretrospectivelyanalyzedandsummarized.Mostofthesecasessufferedfromacuteorsubacuteonsetandexhibitedasensorimotordisorder.Amongthem,sixcasesweremisdiagnosedashavingintramedullarygliomas,andinflammatorydemyelinatingpseudotumorwasonlyidentifiedandpathologicallyconfirmedaftersurgicalresection.Lesionsinthecervicalandthoracicspinalcordwerecommon.Magneticresonanceimagingrevealededemaandspace-occupyinglesionstovaryingdegreesatthecervical-thoracicjunction,withapredominantfeatureofnon-closedrosette-likereinforcement(open-loopsign).Pathologicalexaminationshowedperivascularcuffingofpredominantlydenselymphocytes,anddemyelinationwasobservedinsixofthemisdiagnosedcases.Theseresultssuggestthattumor-likeinflammatorydemyelinatingdiseaseinthespinalcordisakindofspecialdemyelinatingdiseasethatcanbecategorizedasinflammatorypseudotumor.Thesesolitarylesionsareeasilyconfusedwithintramedullaryneoplasms.Patchyornon-closedreinforcement(open-ringsign)onmagneticresonanceimagingisthepredominantpropertyofinflammatorydemyelinatingpseudotumor,andinflammatorycellinfiltrationanddemyelinationareadditionalpathologicalproperties.

简介：Braintumorsincidenceinpediatricagehasbeenestimatedbetween1.3to5%witharelativeincidenceof1.4to11%duringthefirstyearoflife;theimprovementininstrumentaldeviceshasleadtoarelativeincreaseinprecociousdiag-nosis.Thechoicetostudybraintumorsofthefirstyearoflifeasaseparatetopicfrompediatricageonesdependsontheobservationthatthesele-sionshavepeculiarclinical,topographicandtis-sularcharacteristics.Thesurvivalrateofthesepatientsisverypoorifcomparedwiththatfound

简介：根据我们的经验，经历割礼的病人主要关于疼痛和阴茎外观被担心。我们进行了未来的使随机化的试用估计一台新可处理的割礼缝术设备(DCSD)的好处。942个病人的一个总数同等地被划分成三个组(常规割礼，商戒指和可处理的缝术设备组)。在DCSD组的病人是有化合物5%lidocaine乳脂的anesthetized，其它与2%lidocaine阴茎块。操作时间，intra起作用的血损失，切口愈合时间，intra起作用、手术后的疼痛，阴茎外观和全面满足度被测量。操作时间和intra起作用的血损失与传统的组相比在商戒指和缝术设备组是显著地更低的(P<；0.001)。Intra起作用的疼痛与另外的二个组相比是在缝术设备组的更少(P<；0.001)；而手术后的疼痛在与另外的二个组相比的传统的组是更高的(P<；0.001)。设备(80.57%)和商戒指(73.57%)组织的在缝术的病人是与常规割礼组相比对阴茎外观满意的更多(20.06%，P<；0.05)。在缝术设备组的病人也比传统的组快显著地愈合了(P<；0.01)。全面满足率在缝术设备组(78.66%)更好与相比常规(47.13%)并且商戒指(50.00%)组(P<；0.05)。DCSD和lidocaine乳脂的联合导致了更短的操作和切口愈合时间，减少了intra起作用、手术后的疼痛并且改进了对化妆外观的耐心的满足。