简介：

简介：

简介：

简介：蛋白质领域被保存，在相互作用起一个重要作用在之中的机能上地独立的结构联系了蛋白质。域域相互作用最近被用来预言蛋白质蛋白质相互作用(PPI)。一般来说，一双领域的相互作用概率用训练得分功能被获得。令人满意阀值，当“交往”，带那些领域的蛋白质对被考虑。在这研究，蛋白质的签名内容被利用在Saccharomycescerevisiae，Caenorhabditiselegin，和人预言PPI对现代人。蛋白质签名模式的类似被获得，PPI预言基于二进制类似得分函数被拉。结果证明由建议途径的预言的真积极的率用最大的可能性评价方法比那高是约32%，导致在与一个测试集合相比操作的接收装置下面的区域的22%增加什么时候特征(巨鸟)曲线。当包含一个或二签名的蛋白质被移开时，预言的PPI对的敏感显著地增加了。预言的PPI对是平均，11更多半预定在0.95的信心水平比随机的选择交往，并且平均，4比那些由也预言更好预定种系发生的介绍或基因表达介绍。

简介：

简介：预见到未来对大批量晶圆粘合剂和涂层应用的需求，得可已三倍增强其获奖DirEKtCoat技术的工艺能力。DirEKtCoat晶圆涂层工艺达到Cp〉2＠＋／-12．5μm和7微米的总厚度差（TTV），有效地满足了薄晶圆产品目前和未来的需求。

简介：

简介：TheE(envelope)proteinisthesmalleststructuralproteininallcoronavirusesandistheonlyviralstructuralproteininwhichnovariationhasbeendetected.WeconductedgenomesequencingandphylogeneticanalysesofSARS-CoV.Basedongenomesequencing,wepredictedtheEproteinisatransmembrane(TM)pro-teincharacterizedbyaTMregionwithstronghydrophobicityandα-helixcon-formation.Weidentifiedasegment(NH2-_L-Cys-A-Y-Cys-Cys-N_-COOH)inthecarboxyl-terminalregionoftheEproteinthatappearstoformthreedisulfidebondswithanothersegmentofcorrespondingcysteinesinthecarboxyl-terminusoftheS(spike)protein.ThesebondspointtoapossiblestructuralassociationbetweentheEandSproteins.OurphylogeneticanalysesoftheEproteinsequencesinallpub-lishedcoronavirusesplaceSARS-CoVinanindependentgroupinCoronaviridaeandsuggestanon-humananimalorigin.

简介：

简介：Inthispaper,zirconiaisusedastopmoldmaterialforTiinvestmentcasting.Topmoldsamplesaremadebypropermoldbuildingtechnology.Theeffectofdifferentsinteringtemperatureonchemicalcomposition,microstructureandresidualbendingstrengthofthetopmoldsampleisstudied.Thevolumeandhomogeneityoftheairholesinthetopmoldaredeterminedbysinteringtemperature,andfinallydeterminedtheresidualbendingstrengthofthemoldsamplewasdetermined.

简介：现在，个人隐私安全已成为众人关注的焦点。如果你相当在意个人信息安全，担心私密数据被泄露，也许这款Anti—SurveillanceCoat外套能为你解忧。它不仅外型时尚，还可以隔离所有的网络信号和无线电波，

简介：BlueCoat系统公司日前宣布推出整合安全防护与控管能力的WAN优化客户端软件——BlueCoatProxyClient。

简介：随着企业对设计活动越来越重视，以及设计本身内容的不断扩展，设计管理的范围也不断扩大。设计项目管理作为设计管理中的一个方面，涉及如何在创造活动和实现组织目标间进行有效控制的问题，是设计管理中的核心问题。本文主要通过对意大利著名家具品牌MOROSO的一项扶手椅的设计案例的分析，探讨设计项目管理活动的具体实施及其积极作用。

简介：Theadsorptionofproteinonnanoparticleswasstudiedbyusingdynamiclightscatteringtomeasurethehydrodynamicsizeofbothpureproteinandnanoparticlesadsorbedwithdifferentamountsofprotein.Thethicknessoftheadsorbedproteinlayerincreasesasproteinconcentration,butdecreasesastheinitialsizeofnanoparticles.Afterproperlyscalingthethicknesswiththeinitialdiameter,weareabletofitallexperimentaldatawithasinglemastercurve.Ourexperimentalresultssuggestthattheadsorbedproteinsformamonolayeronthenanoparticlesurfaceandtheadsorbedproteinmoleculesareattachedtotheparticlesurfaceatmanypointsthroughapossiblehydrogen-bonding.Ourresultsalsoindicatethatasproteinconcentrationincreases,theoverallshapeoftheadsorbedproteinmoleculecontinuouslychangesfromaflatlayerontheparticlesurfacetoastretchedcoilextendedintowater.Duringthechange,thehydrodynamicvolumeoftheadsorbedproteinincreaseslinearlywithproteinconcentration.

简介：管理生命的自然现象的内在的原则是在最近的年里收到到期的重要性的关键问题之一。没有规模的建筑学的特色是大多数连接节点(中心)的活力。这篇文章的主要目的是由在二个相互作用系统的拓扑的参数上考虑建筑上的模式和中心的移动的后果分析蛋白质蛋白质和果蝇melanogaster的新陈代谢的相互作用网络。分析证明两个相互作用网络跟随一个没有规模的模型，建立从改变的状况，很真实的世界网络遵循小世界模式的事实。平均路径长度出现了一双重并且三方面的增加(从9.42～20.93并且从5.29～17.75变化，分别地)分别地，由于中心的删除为蛋白质蛋白质和新陈代谢的相互作用联网。相反，节点的任意的消除没在蛋白质蛋白质和新陈代谢的相互作用网络的拓扑的参数显示出任何显著不同(平均路径长度：9.42+/-0.02和5.27+/-0.01，分别地)。为二个盒子的这越轨行为强调大多数连接节点的意义到网络的自然拓扑学。

简介：Protein-proteininteractions(PPIs)havebeenwidelystudiedtounderstandthebiologicalprocessesormolecularfunctionsassociatedwithdifferentdiseasesystemslikecancer.Whilefocusedstudiesonindividualcancershavegeneratedvaluableinformation,globalandcomparativeanalysisofdatasetsfromdifferentcancertypeshasnotbeendone.Inthiswork,wecarriedoutbioinformaticanalysisofPPIscorrespondingtodifferentiallyexpressedgenesfrommicroarraysofvarioustumortissues(belongingtobladder,colon,kidneyandthyroidcancers)andcomparedtheirassociatedbiologicalprocessesandmolecularfunctions(basedonGeneOntologyterms).Weidentifiedasetofprocessesorfunctionsthatarecommontoallthesecancers,aswellasthosethatarespecifictoonlyoneorpartialcancertypes.Similarly,proteininteractionnetworksinnucleicacidmetabolismwerecomparedtoidentifythecommon/specificclustersofproteinsacrossdifferentcancertypes.Ourresultsprovideabasisforfurtherexperimentalinvestigationstostudyproteininteractionnetworksassociatedwithcancer.Themethodologydevelopedinthisworkcanalsobeappliedtostudysimilardiseasesystems.

简介：ProteinkinaseRAFisstrategicallylocatedinthe'Ras-MAP-kinasesignaltransductionpathway',aprinciplesystemwhichtransmitssignalsfromgrowthfactorreceptorstothenucleus,resultingincellproliferation.GrowthfactorresponsesaremediatedinpartbyactivationofRas,whichinturnactivatesRAFtophosphorylateMEK,itsdownstreamsubstrate.MEKactivatesMAPkinasetoinfluencenuclearevents.itisclear.however,thatanetworkofsignalsotherthanthosecarredbyRasplaysaroleinRAFregulation.Theseorthogonalinfluencesaremediatedbu:serine/threoninekinases,tyrosinekinases,andprotein-proteininteractions.AsafurthercomplicationtotheRAFnetwork,threeisoformsofRAFhavebeenestablishedwhichhavedivergentN-terminalregulatorydomains,Whereasthesedivergentregulatorydomainsimplicateisoform-specificfunctions,noclearevidenceorhypothesisfordistinctfunctionsforindividualisoformshasbeenpresented.Recently,'isoform-specificproteininteractions'havebeenidentifiedamongnumerousproteinsinteractingwithRAF,ThesestudiesmayservetodelineateindependentfunctionsforRAFisoforms.

简介：AstatisticalthermodynamictheoryoflinearproteinsolutionswasproposedwiththeaidofalatticemodelandappliedtotypeⅠantifreezeprotein(AFPI)solutions.ThenumericalresultsforseveralAFPIsolutionsshowthattheGibbsfunctionofthesolutionhasaminimumatacertainproteinconcentration,buttheproteinchemicalpotentialincreaseswithincreasingtheconcentration.TheinfluencesoftemperatureandproteinchainlengthontheAFPIchemicalpotentialwerealsodiscussed.Theevaluationforthecolligativedepressionofthefreezingpointconfirmsthattheantifreezeactionshouldberecognizedasnon-colligative.Thetheoreticaldeductionfortheconcentrationdependenceofthethermalhysteresisactivitycoincidesqualitativelywiththepreviousexperimentalandtheoreticalresults.

简介：Transmissiblespongiformencephalopathyorpriondiseaseistriggeredbytheconversionfromcellularprionproteintopathogenicprionprotein.Growingevidencehasconcentratedonprionproteinconfigurationchangesandtheircorrelationwithpriondiseasetransmissibilityandpathogenicity.Invivoandinvitrostudieshaveshownthatseveralcytosolicformsofprionproteinwithspecifictopologicalstructurecandestroyintracellularstabilityandcontributetoprionproteinpathogenicity.Inthisstudy,thelatestmolecularchaperonesystemassociatedwithendoplasmicreticulum-associatedproteindegradation,theendoplasmicreticulumresidentproteinquality-controlsystemandtheubiquitinationproteasomesystem,isoutlined.Themolecularchaperonesystemdirectlycorrelateswiththeprionproteindegradationpathway.Understandingthemolecularmechanismswillhelpprovideafascinatingavenueforfurtherinvestigationsonpriondiseasetreatmentandprionprotein-inducedneurodegenerativediseases.

简介：这研究的目的是调查形态学，在锦鸡儿属植物arborescens的种子梗的光合的产品的传播线路打。在在flowering以后的各种各样的阶段并且用扫描电子显微镜学在种子成熟评估种子梗的角色。我们发现成熟种子梗主要由容器，sclerenchymatous房间和parenchymatous房间组成了。伸长的房间在在种子梗和种子之间的连接形成了一枚戒指，并且一大空被sclerenchymatous房间的二层在内部种子生产，它工作支撑种子生长。在戒指的中心的洞在当种子成熟，扩大的种子开发，和洞的一个早阶段期间被关上。为材料运输有二条线路，它从种子梗开始了：从种子上衣的到胚胎，和直接进入胚胎的另外一个。容器，充满种子梗，是为由种子的营养素的吸收的小径。容器浓密地在种子梗被包装，并且容器的房间墙的第二等的变厚被网络线变厚描绘，当在种子以内的容器的房间墙的第二等的变厚被螺丝钉线变厚描绘时。容器的词法特征对它的功能适应。