简介：buttheYANXIANGERPpersistsfinallyandobtainssuccess.ThenewERPsystemhelpstheYANXIANGLtdalot.Theoutputvalueturnsdouble,theYANXIANGLtd.ManagementteamdecideuseERPsystemtomanagetheenterpriseinformationandplantheenterpriseresource.Althoughmetlotsofhindranceinimplementationprocess,makestheseinformationobtainthebiggesteffect.ERPandtheenterpriseisonewholegroup.Eachonecannotlack.4.ThemanagementimprovementwillcontinueAlongwiththeERPsystemandtheenterpriserationalization

简介：Amodifiedsnap-throughmechanismisusedinanelectromagneticenergyharvestertoimproveitseffectiveness.Itmainlycomprisesthreespringsthatarecon-figuredsothatthepotentialenergyofthesystemhastwostableequilibriumpoints.Inparticular,thesmallvibrationbehavioroftheharvesteraroundoneoftheequilibriumsisofinterest.Amulti-scalemethod(MSM)isusedtoanalyzethefrequencyresponsecurve.Twosnap-throughmechanismsareconsidered.Onehasbothhorizontalandverti-calsprings.Theotherhasonlyhorizontalsprings.Thefrequencyresponsecurvesofthesetwoclassesarecomparedunderthesameexcitationandelectricloadingconditions.Thelatterexhibitsmorebendingofthefrequencyresponsecurvethantheformerone.Theresultsarealsovalidatedbysomenumericalwork.TheaveragedpowersubjecttotheGaussianwhitenoiseiscalculatednumerically,andtheresultsdemonstratethatbi-stableenergyharvestingwithonlyhorizontalspringscanoutperformthemechanismwithbothhorizontalandverticalspringsforthesamedistancebetweentwoequilibriums.

简介：Duetodramaticallyincreasinginformationpublishedinsocialnetworks,privacyissueshavegivenrisetopublicconcerns.Althoughthepresenceofdifferentialprivacyprovidesprivacyprotectionwiththeoreticalfoundations,thetrade-offbetweenprivacyanddatautilitystilldemandsfurtherimprovement.However,mostexistingstudiesdonotconsiderthequantitativeimpactoftheadversarywhenmeasuringdatautility.Inthispaper,wefirstlyproposeapersonalizeddifferentialprivacymethodbasedonsocialdistance.Then,weanalyzethemaximumdatautilitywhenusersandadversariesareblindtothestrategysetsofeachother.Weformalizeallthepayofffunctionsinthedifferentialprivacysense,whichisfollowedbytheestablishmentofastaticBayesiangame.Thetrade-offiscalculatedbyderivingtheBayesianNashequilibriumwithamodifiedreinforcementlearningalgorithm.Theproposedmethodachievesfastconvergencebyreducingthecardinalityfromnto2.Inaddition,thein-placetrade-offcanmaximizetheuser'sdatautilityiftheactionsetsoftheuserandtheadversaryarepublicwhilethestrategysetsareunrevealed.Ourextensiveexperimentsonthereal-worlddatasetprovetheproposedmodeliseffectiveandfeasible.

简介：Themassflowrateofagranularflowthroughanapertureundergravityisalong-standingchallengeissueinphysicalscience.Weshowthatforsteadyflowfieldclosetolaminarflow,thedynamicalequationstogetherwiththecontinueequationandMohr-circledescriptionofthestressareclosed,andhencesolvable.Inacaseofstreamlineguidedbythetwo-dimensionalhopper,weobtainaconsistentconditionanduseittodeterminethestressandthevelocitydistribution.Ourresultindicatesthat3/2powerscalingbehaviorisrecoveredwithacoefficientC(μ,α)beingafunctionoffrictionalcoefficientandthehopperangle.ItisfoundthatthepredictedcoefficientC(μ,α)iscompatiblewithpreviousstudies.

简介：Estuarineprocessesinthearcticlagoonsareamongtheleaststudiedbutimportantsubjects,especiallyconsideringtherapidwarmingofarcticwaterwhichmaychangethelengthofice-freeperiodinthesummer.Inthispaper,wind-drivenexchangeflowsinthemicro-tidalElsonLagoonofnorthernAlaskawithmultipleinletsofcontrastingwidthsanddepthsarestudiedwithinsituobservations,statisticalanalysis,numericalexperiments,aregressionmodelonthebasisofdynamics,andremotesensingdata.WatervelocityprofileswereobtainedfromabottomdeployedacousticDopplercurrentprofiler(ADCP)inthenorthwesternEluitkakPassconnectingtheBeaufortSeatotheElsonLagoonduringa4.9dayice-freeperiodinthesummerof2013.Thesubtidalflowisfoundcorrelatedwithwind(R~2value~96%).Frequentlyoccurringeast,northeastandnorthwindsfromthearcticatmospherichigh-andlow-pressuresystemspushwaterfromtheBeaufortSeaintothelagoonthroughthewideinletsontheeasternsideofthelagoon,resultinginanoutwardflowagainstthewindatthenarrownorthwesterninlet.Thecounter-windflowisaresultofanunevenwindforcingactingthroughtheasymmetricinletsanddepth,aneffectof'torque'orvorticity.Undernorthwestwind,theexchangeflowatthenorthwesterninletreversesitsdirection,withinwardflowsthroughtheupwindnorthwesterninletandoutwardflowsthroughthedownwindeasterninlets.AregressionmodelisestablishedbasedonthemomentumequationsandTaylorseriesexpansions.ThemodelisusedtopredictflowsinJulyandAugustof2015andJulyof2017,supportedbyavailableLandsatsatelliteimages.About73%–80%ofthetimetheflowsatEluitkakPassareoutofElsonLagoonforthesummerof2015and2017.Numericalexperimentsareconductedtocorroboratethefindingsandillustratetheeffectsundervariouswindconditions.Aquasi-steadystatebalancebetweenwindforceandsurfacepressuregradientisconfirmed.

简介：Objective:Theaimofthepresentstudywastoanalyzetheprognosticfactorsinpatientswithhepatoblastoma(HB)inoursinglecenterandtoevaluateperiostin(POSTN)expressioninHBanditsassociationwithclinicopathologicalvariables.Inaddition,theunderlyingmechanismofhowPOSTNpromotesHBprogressionwasdiscussed.Methods:POSTNexpressionwasinvestigatedinHBtumorsbyimmunohistochemistry(IHC),immunofluorescence(IF)andWesternblot(WB).TheassociationamongPOSTNexpression,clinicopathologicalfeaturesandoverallsurvival(OS)wasalsoevaluated.ThemigrationandadhesionabilityofHBcellsweremeasuredusingchemotaxisandcell-matrixadhesionassays,respectively.Epithelial-mesenchymaltransition(EMT)-associatedmarkersandactivationoftheERKpathwayweredetectedbyWB.Results:HBpatientshadpoorprognosiswhichdisplayedlymphnodemetastasis,vascularinvasion,POSTNandvimentinexpression.POSTNexpressionwasalsoassociatedwithlymphnodemetastasis.Furthermore,overexpressedPOSTNpromotedmigrationandtheadhesiveabilityofHBcellsinvitro.Inaddition,wedemonstratedthatPOSTNactivatedtheMAPK/ERKpathway,upregulatedtheexpressionofSnailanddecreasedtheexpressionofOVOL2.Finally,POSTNpromotedtheexpressionofEMT-associatedmarkers.Conclusions:POSTNmightmodulateEMTviatheERKsignalingpathway,therebypromotingcellularmigrationandinvasion.OurstudyalsosuggeststhatPOSTNmayserveasatherapeuticbiomarkerinHBpatients.

简介：Asimpleone-potnon-isocyanaterouteforsynthesizingthermoplasticpolyureasispresented.Insituurethanizationwasconductedfromthering-openingreactionofethylenecarbonatewithpoly(propyleneglycol)bis(2-aminopropylether)andhexanediamine,m-xylylenediamine,ordiethyleneglycolbis(3-aminopropyl)etherat100℃for6hundernormalpressure.Melttransurethanepolycondensationwassuccessivelyconductedat170℃underareducedpressureof399Pafordifferenttimeperiods.Aseriesofnonisocyanatethermoplasticpolyureas(NI-TPUreas)wereprepared.TheNI-TPUreaswerecharacterizedbygelpermeationchromatography,FTIR,1H-NMR,differentialscanningcalorimetry,thermogravimetricanalysis,wide-angleX-raydiffraction,atomicforcemicroscopy,andtensiletest.NI-TPUreasexhibitedMnofupto1.67×10^4g/mol,initialdecompositiontemperatureover290℃,andtensilestrengthofupto32MPa.SeveralcrystallizableNI-TPUreasexhibitedTmexceeding98℃.NI-TPUreaswithgoodthermalandmechanicalpropertieswerepreparedthroughagreenandsimpleone-potnon-isocyanateroute.

简介：Purpose:Thisstudyaimstocompareadolescents’cardiometabolicriskscorethroughanintegrativeclassificationofphysicalactivity(PA),whichinvolvesthecombinationofmoderate-to-vigorousphysicalactivity(MVPA)andsedentarybehavior(SB).Methods:Across-sectionalstudyderivedfromtheHealthyLifestyleinEuropebyNutritioninAdolescenceCross-SectionalStudydatabase(2006-2008)wasconductedinadolescents(n=548;boys,47.3%;14.7±1.2years)from10Europeancities.MVPAandSBwereobjectivelymeasuredusingaccelerometry.Adolescentsweredividedinto4categoriesaccordingtoMVPA(meetingornotmeetingtheinternationalrecommendations)andthemedianofSBtime(aboveorbelowsex-andage-specificmedian)asfollows:High-SB&Inactive,Low-SB&Inactive,High-SB&Active,andLow-SB&Active.Aclusteredcardiometabolicriskscorewascomputedusingthehomeostaticmodelassessment,systolicbloodpressure,triglycerides,totalcholesterol/high-densitylipoproteincholesterol,sum4skinfolds,andcardiorespiratoryfitness(CRF).AnalysesofcovariancewereperformedtodiscerndifferencesoncardiometabolicriskscoresamongPAcategoriesandeachhealthcomponent.Results:ThecardiometabolicriskscorewaslowerinadolescentsmeetingtheMVPArecommendationandwithlesstimespentinSBincomparisontothehigh-SB&Inactivegroup(p<0.05).However,nodifferenceincardiometabolicriskscorewasestablishedbetweenHigh-SBorLow-SBgroupsininactiveadolescents.ItisimportanttonotethatCRFwastheonlyvariablethatshowedasignificantmodification(higher)whenchildrenwerecomparedfromthecategoryofphysicallyinactivewith"active"butnotfromhigh-tolow-SB.Conclusion:Beingphysicallyactiveisthemostsignificantandprotectiveoutcomeinadolescentstoreducecardiometabolicrisk.LowerSBdoesnotexhibitasignificantandextrabeneficialdifference.

简介：Purpose:Theobjectiveofthepresentstudywastodeterminewhetheradenervatedmuscleextract(DmEx)couldstimulatesatellitecellresponseindenervatedmuscle.Methods:Wistarratsweredividedinto4groups:normalrats,normalratstreatedwithDmEx,denervatedrats,anddenervatedratstreatedwithDmEx.Thesoleusmuscleswereexaminedusingimmunohistochemicaltechniquesforproliferatingcellnuclearantigen,desmin,andmyogenicdifferentiationantigen(MyoD),andelectronmicroscopywasusedforanalysisofthesatellitecells.Results:Theresultsindicatethatwhiledenervationcausesactivationofsatellitecells,DmExalsoinducesmyogenicdifferentiationofcellslocalizedintheinterstitialspaceandtheformationofnewmusclefibers.AlthoughDmExhadasimilareffectinnatureoninnervatedanddenervatedmuscles,thisresponsewasofgreatermagnitudeindenervatedvs.intactmuscles.Conclusion:OurstudyshowsthattreatmentofdenervatedratswithDmExpotentiatesthemyogenicresponseinatrophicdenervatedmuscles.

简介：Itisaverydifficulttasktodevelopamethodofreducingturbulentboundarylayerdrag.However,inrecentyears,plasmaflowcontroltechnologyhasdemonstratedhugepotentialinfrictiondragreduction.Tofurtherinvestigatethisissue,asmoothplatemodelwasdesignedasatestingobjectarrangedwithabidirectionaldielectric-barrier-discharge(DBD)plasmaactuator.Inaddition,measurementofskinfrictiondragwasachievedbyapplyinghotwireanemometrytoobtainthevelocitydistributionoftheturbulentboundarylayer.AmethodofquantifyingthefrictiondrageffectwasadoptedbasedontheSpaldingformulafittedwiththeexperimentdata.Whenplasmaactuationwasconducted,avelocitydefectoccurredatthetwomeasuringpositions,comparedwiththenoplasmacontrolcondition;thismeansthattheDBDplasmaactuationcouldreducethedragsuccessfullyinthedownstreamoftheactuator.Moreover,dragreductioncausedbybackwardactuationwasslightlymoreefficientthanthatcausedbyforwardactuation.Withanincreasingdistancefromplasmaactuation,thedrag-reductioneffectcouldbecomeweaker.Experimentalresultsalsoshowthattheimprovementofdrag-reductionefficiencyusingaDBDplasmaactuatorcanachieveabout8.78%inthelocalregionoftheexperimentalflatmodel.