学科分类
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11 个结果
  • 简介:Polyethylenimine-polyL-lysinePEI-PLL共聚物经由PEI开始的L离氨酸N-carboxyanhydrideLysZ-NCA的戒指洞聚合被综合。有siRNA的PEI-PLL的complexation被粒子尺寸和希腊语的第六个字母潜力大小学习。流动cytometric分析和共焦的成像显示出它的优秀细胞内部的trafficking能力。PEI-PLL在vitro比商业PEI-25k显示了更高的基因silencing效率和更低的cytotoxicity。在antitumor学习,PEI-PLL进一步与siVEGF被相结合并且显然为CT26肿瘤模型的处理显示出肿瘤抑制效果。因此,PEI-PLL是在vivo的进一步的antitumor处理的一个有希望的siRNA搬运人候选人。

  • 标签: L-赖氨酸 SIRNA 聚乙烯亚胺 肿瘤治疗 载体 酸改性
  • 简介:Cross-culturalmanagementisoftenregardedasadisciplineofinternationalmanagementfocusingonculturalencountersbetweentheorganizationandthenation-state,andprovidingtoolstotackleculturaldifl'erencesseenassourcesofconflict,frictionormisunderstanding.BasedonGreetHofstede'sCulturalModel,thispaperattemptstoshedsomelightoneffectivecorporationmanagementthroughculturalanalysisofthedifl'erencesbetweenChinaandwesterncountries.Thepaperputsmoreemphasisontheimpactofculturalcompatibilityoneffectivecorporationman-agementthroughthecasestudyofChina,Japan,GermanyandAmerica.Theauthorarguesthatmanagersandemploy-eesinvolvedincompanieswithdiverseculturalbackgroundsshouldbeintegratedanddevelopedintoaspecificlocalcontextthroughinterlockingtheirculturalidentificationsandtheorganizationalpractices.

  • 标签: CULTURAL DIFFERENCES CULTURAL Four-Dimensional Model CULTURAL
  • 简介:NanofluidswerepreparedbydispersingCunanoparticles(~20nm)inn-tetradecanebyatwo-stepmethod.Theeffectivethermalconductivitywasmeasuredforvariousnanoparticlevolumefractions(0.0001-0.02)andtemperatures(306.22-452.66K).TheexperimentaldatacompareswellwiththeJangandChoimodel.Thethermalconductivityenhancementwaslowerabove391.06Kthanforthatbetween306.22and360.77K.Theinterfacialthermalresistanceincreasedwithincreasingtemperature.Theeffectivethermalconductivityenhancementwasgreaterthanthatobtainedwithamoreviscousfluidasthebasemediaat452.66KbecauseofnanoconvectioninducedbynanoparticleBrownianmotionathightemperature.

  • 标签: 有效热导率 铜纳米粒子 纳米流体 高温度 颗粒体积分数 有效导热系数
  • 简介:Weinvestigatetheinteractionbetweenapositivemassandanegativeeffectivemassthroughathreemasschainconnectedwithelasticsprings,apairofmassesisdesignedtohaveaneffectivenegativemass,anditinteractswiththethirdpositiveoneasifanequivalenttwo-masschain.Thedynamicsoftheequivalenttwo-masschainshowsthatthetwobodiesmaybeself-acceleratedinsamedirectionwhentheeffectivemassbecomesnegative,theexperimentisalsoconductedtodemonstratethistypeofmotion.Wefurthershowthattheenergyprinciple(Hamilton’sprinciple)isapplicableiftheenergyofthenegativemassunitisproperlycharacterized.Theresultmayberelevanttocompositewithcellsofeffectivenegativemass,theirinteractionwithmatrixmayleadtomorericherunexpectedmacroscopicresponses.

  • 标签: 负有效质量 质量弹簧系统 相互作用 实验 能量原理 哈密顿原理