简介：Americaneatingisfunny.Theyeat_1everythingwithafork,anditappearsthat_2aknifeinone'srighthandlongerthanafewsecondsisconsideredtobe_3goodtablemanners.Thesystemisthatifitisreallynecessarytousea_4,peopletaketheforkintheirlefthand,andcutoffapieceofmeatorwhateveritisinthe_5manner.Thentheyputtheknifedown,changetheforktotheir_6,andonlythendotheyputthefoodtotheirmouth.Thisisclearlyridiculous,butitisconsideredgood_7.Thereareseveralresultsofthissystem.First,ifitisnotreally_8touseaknife,Americansdon'tuse_9,becauseobviouslythisgreatlymakes

简介：Leavingatipinarestauranthasbecomeacustominmostcountries.Theword“tip”camefromtheLatinword“Gratis”,meaningfree.Tipsaredefinedassmallgiftsofmoneyforserviceinadditiontothepaymentdue.

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简介：忙碌的工作、紧张的生活，让吃饭越来越成为一种形式：而讲究生活品质的“慢食”，却已在我们中间悄然兴起。人们利用休息时间，买来新鲜的蔬菜、鱼、虾，为自己、亲人和朋友做饭。人们一起坐到餐桌前享受晚餐，真地会很美妙√隧食。让我们巩固了感情，也让我们有了放松身心、缓解精神压力的机会。校园慢食活动也让学生们有了了解自然、亲近自然、养成良好生活习惯的机会。

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简介：Wepresentasemi-customdesignmethodologybasedontransistortuningtooptimizethedesignperformance.Comparedwithothertransistortuningapproaches,ourtuningprocesstakesthecross-talkeffectintoaccountandprominentlyreducesthecomplexityforcircuitsimulationandanalysisbydecomposingthecircuitnetworkutilizinggraphtheory.Furthermore,theincrementalplacementandroutingforthecorrespondingtransistortuninginconventionalapproachesisnotrequiredinourmethodology,whichmightinducetiminggraphvariationandadditionaliterationsfordesignconvergence.Thismethodologycombinestheflexibleautomatedcircuittuningandphysicaldesigntoolstoprovidemoreopportunitiesfordesignoptimizationthroughoutthedesigncycle.

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简介：High-throughputSNPgenotypingplatformsuseautomatedgenotypecallingalgo-rithmstoassigngenotypes.Whilethesealgorithmsworkefficientlyforindividualplatforms,theyarenotcompatiblewithotherplatforms,andhaveindividualbiasesthatresultinmissedgenotypecalls.HerewepresentdataontheuseofasecondcomplementarySNPgenotypeclusteringalgorithm.ThealgorithmwasoriginallydesignedforindividualfluorescentSNPgenotypingassays,andhasbeenopti-mizedtopermittheclusteringoflargedatasetsgeneratedfromcustom-designedAffymetrixSNPpanels.Inananalysisofdatafroma3Karraygenotypedon1,560samples,theadditionalanalysisincreasedtheoverallnumberofgenotypesbyover45,000,significantlyimprovingthecompletenessoftheexperimentaldata.Thisanalysissuggeststhattheuseofmultiplegenotypecallingalgorithmsmaybead-visableinhigh-throughputSNPgenotypingexperiments.ThesoftwareiswritteninPerlandisavailablefromthecorrespondingauthor.

简介：AbstractBackground:Computed tomography (CT) and magnetic resonance imaging (MRI) data can be fused to identify the tumor boundaries. This enables surgeons to set close but tumor-free surgical margins and excise the tumor more precisely. This study aimed to report our experience in performing computer navigation-aided joint-preserving resection and custom-made endoprosthesis reconstruction to treat bone sarcoma in the diaphysis and metaphysis of the femur and tibia.Methods:Between September 2008 and December 2015, 24 patients with bone sarcomas underwent surgical resection and joint-sparing reconstruction under image-guided computer navigation. The cohort comprised 16 males and eight females with a median age of 19.5 years (range: 12-48 years). The tumor location was the femoral diaphysis in three patients, distal femur in 19, and proximal tibia in two. The tumors were osteosarcoma (n = 15), chondrosarcoma (n = 3), Ewing sarcoma (n = 3), and other sarcomas (n = 3). We created a pre-operative plan for each patient using navigation system software and performed navigation-aided resection before reconstructing the defect with a custom-made prosthesis with extracortical plate fixation.Results:Pathological examination verified that all resected specimens had appropriate surgical margins. The median distance from the tumor resection margin to the joint was 30 mm (range: 13-80 mm). The median follow-up duration was 62.5 months (range: 24-134 months). Of the 24 patients, 21 remain disease free, one is alive with disease, and two died of the disease. One patient developed local recurrence. Complications requiring additional surgical procedures occurred in six patients, including one with wound hematoma, one with delayed wound healing, one with superficial infection, one with deep infection, and two with mechanical failure of the prosthesis. The mean Musculoskeletal Tumor Society score at the final follow-up was 91% (range: 80%-100%). The 5- and 10-year implant survival rates were 91.3% and 79.9%, respectively.Conclusions:Computer navigation-aided joint-preserving resection and custom-made endoprosthesis reconstruction with extracortical plate fixation is a reliable surgical treatment option for bone sarcoma in the diaphysis and metaphysis of the femur and tibia.

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