简介:跨界——这个概念在各个领域都有着不小的影响力.但唯独在汽车这个行业,跨界似乎并不像我们想象的那么成功.如今,跨界早已不再是小车的专利,旅行车、豪华车都纷纷开始玩起了自己的跨界之路.其实国人对于跨界车这一概念并不陌生,因为国内的汽车市场从很早就开始了这方面的尝试,如2012年末,经济型小车东风雪铁龙C2Cross上市,到之后合资的CrossPolo出现,再到后来中高档Cross车型3.0升歌诗图的高调引入国内,其虽轰动一时却并未带来多少实际销量.直到中期改款2.4升的歌诗图上市后,情况才得以好转.可以说CROSS车型在国内汽车市场最为井喷的时代虽偶有新作,但却一直未能真正博得中国消费者们的青睐.
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简介:教材:人教版新目标英语八年级(下)单元:HaveyoureadTreasureIslandyet?课文:ACountryMusicSongChangedHerLifeForeverTeachingobjectivesBytheendoftheperiod,theteachermustenablethestudentsto:1.Understandthepassageandmastersomereadingstrategies.2.Summarizethepassagebymakingnotesandunderliningthemainideas.3.
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简介:Thequestforneuroprotectivedrugstoslowtheprogressionofneurodegenerativediseases(NDDs),includingAlzheimer'sdisease(AD),Parkinson'sdisease(PD),andHuntington'sdisease(HD),hasbeenlargelyunrewarding.Preclinicalevidencesuggeststhatrepurposingquetiapine,lithium,valproate,fluoxetine,donepezil,andmemantineforearlyandpre-symptomaticdisease-modificationinNDDsmaybepromisingandcanspareregulatorybarriers.Theliteratureofthesepsychotropicsinearlystageandpre-symptomaticAD,PD,andHDisreviewedandpropitiousfindingsfollow.Mildcognitiveimpairment(MCI)phaseofAD:salutaryhumanrandomizedcontrolledtrialfindingsforlow-doselithiumand,inselectedpatients,donepezilawaitreplication.Pre-symptomaticAD:humanepidemiologicaldataindicatethatlithiumreducesADrisk.Animalmodelstudies(AMS)revealencouragingresultsforquetiapine,lithium,donepezil,andmemantine.EarlyPD:valproateAMSfindingsshowpromise.Pre-symptomaticPD:lithiumandvalproateAMSfindingsareencouraging.EarlyHD:uncontrolledclinicaldataindicatenon-progressionwithlithium,fluoxetine,donepezil,andmemantine.Pre-symptomaticHD:lithiumandvalproateareauspiciousinAMS.Manyotherpromisingfindingsawaitingreplication(valproateinMCI;lithium,valproate,fluoxetineinpre-symptomaticAD;lithiuminearlyPD;lithium,valproate,fluoxetineinpre-symptomaticPD;donepezilinearlyHD;lithium,fluoxetine,memantineinpre-symptomaticHD)arereviewed.Dose-andstage-dependenteffectsareconsidered.Suggestionsforsignal-enhancementinhumantrialsareprovidedforeachNDDstage.