简介：·AIM:Toevaluateandcompareaspherictoricintraocularlens(IOL)implantationandasphericmonofocalIOLimplantationwithlimbalrelaxingincisions(LRI)tomanagelowcornealastigmatism(1.0-2.0D)incataractsurgery.·METHODS:Aprospectiverandomizedcomparativeclinicalstudywasperformed.Therewererandomlyrecruited102eyes(102patients)withcataractsassociatedwithcornealastigmatismanddividedintotwogroups.ThefirstgroupreceivedtoricIOLimplantationandthesecondonemonofocalIOLimplantationwithperipheralcornealrelaxingincisions.Outcomesconsideredwere:visualacuity,postoperativeresidualastigmatism,endothelialcellcount,theneedforspectacles,andpatientsatisfaction.Todeterminethepostoperativetoricaxis,allpatientswhounderwentthetoricIOLimplantationwerefurtherevaluatedusinganOPDScanIII(NidekCo,Japan).Follow-uplasted6mo.·RESULTS:Themeanuncorrecteddistancevisualacuity(UCVA)andthebestcorrectedvisualacuity(BCVA)demonstratedstatisticallysignificantimprovementaftersurgeryinbothgroups.Attheendofthefollow-uptheUCVAwasstatisticallybetterinthepatientswithtoricIOLimplantscomparedtothosepatientswhounderwentimplantationofmonofocalIOLplusLRI.Themeanresidualrefractiveastigmatismwasof0.4DforthetoricIOLgroupand1.1DfortheLRIgroup(P<0.01).Nodifferencewasobservedinthepostoperativeendothelialcellcountbetweenthetwogroups.·CONCLUSION:Thetwosurgicalproceduresdemonstratedasignificantdecreaseinrefractiveastigmatism.ToricIOLimplantationwasmoreeffectiveandpredictablecomparedtothelimbalrelaxingincision.

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简介：客观：在在人的创伤的奔流和正常透镜的上皮的房间之间的原子factor-KB(NF-κB)的表示学习差别。方法：全部的RNAof前面的囊标本从受不了创伤的奔流做半量的RT-PCR并且在在他们之间的NF-κB的表示进行差别的分析的正常cadaveric眼睛施主和那些在显微镜下面被拿。结果：作为与在正常控制组的0.8337的平均数相比，NF-κB的表示等价物为在创伤的奔流患者的透镜的上皮的房间是0.9074，并且差别具有显著意义(t=2.447，P<0.05)因此。结论：NF-κB是可能的对必要的一种抄写因素维持正常透镜的上皮的房间的新陈代谢。在创伤的奔流患者可得到的更高的NF-κB“透镜的上皮的房间工具NF-κB具有到创伤的奔流的出现和开发的可能的关联的s。

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简介：AIM:Tocomparethesafetyandefficacyofphacoemulsificationandsmallincisioncataractsurgery(SICS)inpatientswithuveiticcataract.·METHODS:Inaprospective,randomizedmulti-centricstudy,consecutivepatientswithuveiticcataractwererandomizedtoreceivephacoemulsificationormanualSICSbyeitheroftwosurgeonswellversedwithboththetechniques.Aminimuminflammationfreeperiodof3mo(definedaslessthan5cellsperhighpowerfieldinanteriorchamber)wasapre-requisiteforeligibilityforsurgery.Superiorscleraltunnelincisionswereusedforbothtechniques.Improvementinvisualacuitypost-operativelywastheprimaryoutcomemeasureandtherateofpost-operativecomplicationsandsurgicaltimeweresecondaryoutcomemeasures,respectively.Meansofgroupswerecomparedusingt-tests.Onewayanalysisofvariance(ANOVA)wasusedwhenthereweremorethantwogroups.Chi-squaretestswereusedforproportions.KaplanMeyersurvivalanalysiswasdoneandmeansforsurvivaltimewasestimatedat95%confidenceinterval(CI).APvalueof<0.05wasconsideredstatisticallysignificant.·RESULTS:Onehundredandtwenty-sixof139patients(90.6%)completedthe6-monthfollow-up.Sevenpatientswerelostinfollowupandanothersixexcludedduetoeitherfollow-uplessthansixmonths(n=1)orinabilityimplantanintraocularlens(IOL)becauseofinsufficientcapsularsupportfollowingposteriorcapsulerupture(n=5).Therewassignificantimprovementinvisionafterboththeprocedures(pairedt-test;P<0.001).Onfirstpostoperativeday,uncorrecteddistancevisualacuity(UDVA)was20/63orbetterin31(47%)patientsinPhacogroupand26(43.3%)patientsinSICSgroup(P=0.384).Themeansurgicallyinducedastigmatism(SIA)was0.86±0.34dioptres(D)inthephacoemulsificationgroupand1.16±0.28DinSICSgroup.Thedifferencebetweenthegroupswassignificant(t-test,P=0.002).At6mo,correcteddistancevisualacuity(CDVA)was20/60orbetterin60(90.9%)patientsinPhacogroupand53

简介：AIM:Toidentifythe100mostcitedpapersincataractsurgery,weperformedacomprehensivebibliometricanalysisbasingontheliteraturesearchontheThomsonReutersWebofKnowledge.METHODS:Thenumberofcitations,includingthetotalcitations,latest5ycitationsandaveragecitationnumberperyear(ACY),authorship,yearofpublication,majortopics,journalofpublication,countryandinstitutionoforiginofeachpaperwererecordedandthenanalyzed.Pearson'scorrelationanalysiswasconductedtoevaluatethecorrelationbetweenthepublishedyearandthenumberofcitations.Thecorrelationbetweenjournal'simpactfactor(IF)andnumberofcitationswasassessedaswell.RESULTS:ThemostcitedpaperwastheclassicpaperdonebytheEuropeanSocietyofCataract&RefractiveSurgeons(ESCRS)group.Thispaperfocusedonthetopicofendophthalmitis.NotonlythemostcitedpapersoriginatedfromtheUSA,butalsosomeAmericaninstitutionslikeJohnsHopkinsUniversity,HarvardMedicalSchool,etc.hadthemostcitations.Pearson'scorrelationanalysisindicatedthatthelatest5ycitationsandACYweresignificantlyrelatedwiththepublishedyear(5ycitations:r=0.615,P<0.001;ACY:r=0.657,P<0.001),whereasnoassociationbetweenthetotalnumberofcitationsandpublishedyearwasfound(r=0.045).Moreover,theIFsofjournalswerefoundtohavenosignificanteffectonthenumberoftotalcitations.CONCLUSION:Toourknowledge,thisisthefirststudyonthemostinfluentialpapersincataractsurgeryafteracomprehensiveresearchofrelevantliteratures.Thepresentworkmayprovideusconciseinformationconcerningthedevelopmenthistoryofcataractsurgeryoverthepast66y.

简介：AIM:Toevaluatetheindications,complications,andvisualandgraftsurvivaloutcomesineyesthathadundergonesimultaneouscataractextractionandpenetratingkeratoplasty(PKP).·METHODS:Wedescribedaretrospectivestudyof101patientswhohadundergonesimultaneouscataractextractionandPKPatKingKhaledEyeSpecialistHospitalbetweenJanuary1,2001,andDecember31,2002.Allpatientswerefolloweduppostoperativelywithmaximumfollow-up68months.·RESULTS:Themeanageofpatientswas61years.Themeanoverallfollow-upwas27months.Themostcommonindicationsforsurgerywerecornealscarring(45.5%),previousfailedgraft(15.8%),cornealulcer(12.9%),Fuchsendothelialdystrophy(8.9%),stromaldystrophy(2.9%),andotherconditions(14.5%).Overall,69grafts(68.3%)remainedclearatfinalfollow-up.Previousglaucomaorpostoperativeglaucomahadnostatisticallysignificanteffectsongraftoutcome(P>0.05).Thegraftrejectionrate(17.8%)wasasignificantriskfactorforfailure(P=0.00).Age,gender,indicationsforsurgery,cornealgraftdiameter,andintraoperativevitreouslosshadnostatisticallysignificanteffectsonthePKPoutcome(P>0.05).Postoperativevisualacuitywassignificantlyassociatedwithpreoperativevisualacuity(P<0.01).·CONCLUSION:Thepresentstudyprovidesevidencethatperformingacombinedprocedureresultsinmorerapidvisualrehabilitationandgoodgraftclarity.

简介：AIMTo鉴别在透明婴儿透镜和先天的cataract.METHODSLens相关的miRNAs的中央上皮的透镜相关的microRNAs(miRNAs)的表示从PubMed被检索数据库。在透明婴儿透镜和先天的奔流的这些miRNAs的表示层次被茎环颠倒抄写聚合酶链反应(RT-PCR)决定。人权保护的算法被用来预言这些差别的目标基因表示了miRNAs。目标mRNA是validated.RESULTSSix透镜相关的miRNAs从屏蔽PubMed被检索数据库。在透明婴儿透镜的最丰富的miRNA根据茎环RT-PCR是miR-184。miR-182在先天的奔流是起来调整的。相反地，miR-204和miR-124是下面调整的。miR-204比miR-124在表示展出了更重要的减少。另外，Meis2被预言是用人权保护的算法的miR-204的目标。miR-204mimic/antagomirtransfection实验建议了在miR-204的表示之间的否定关联，建议他们在先天的奔流的致病的参与并且miR-182，miR-204和miR-124的Meis2.CONCLUSIONThe表示层次在透明婴儿透镜和先天的奔流的中央上皮之间不同。miR-204可以经由silencingMeis2行动调整透镜开发和先天的奔流形成。

简介：AIMTo评估剩余的excimer激光修正的功效和安全在有intraocular的奔流抽取以后的折射错误透镜(IOL)培植在不平常cases.METHODSTotally有高剩余的24个病人在有IOL培植的奔流外科以后的折射错误被检验。22个病人有phacoemulsification和IOL培植的历史，并且二与IOL培植有囊外的奔流抽取。外科手术前的医药记录的详细检查被做解释奔流以后的折射错误的起源。所有病人经历了photorefractirekeratectomy(PRK)改进。吝啬的结果措施是折射，uncorretted视觉尖酸(UCVA)，最好改正的视觉尖酸(BCVA)和角膜的透明性并且列在后面在上面从1到剩余变常眼的8y.RESULTSThe主管原因是在有高近视和先天的透镜畸形的反常眼睛的不精确的IOL计算，两个都由角膜的散光列在后面导致的缝术并且先存在。在奔流外科以后并且在激光改进前，吝啬的球形的等价物(SE)是-0.56?潢吗？

简介：AIMTo评估变化在phacoemulsification(PC)和femtosecond激光(FSL)期间帮助了的血压(BP)奔流surgery.METHODSA回顾的图表评论为从2013年7月收到了传统的phacoemulsification外科(PC组)和帮助FSL的奔流外科(FS组)到2014年12月的所有病人被执行。完全，从收到过程的二种类型的133个病人的206只眼睛被包括。耐心的特征(年龄，性，和高血压历史)，外科手术前、手术后的位／秒是收缩的collected.RESULTSThe支持operative，心脏舒张的位／秒(公里Hg)是124.89摥琠?桴?楳楬潣敮瀠畬？

简介：AIM:Toidentifyriskfactorsassociatedwithpost-cataractsurgeryendophthalmitis(PCE)intype2diabeticpatients.METHODS:Ahospital-basedretrospectivecase-controlstudywasconductedon194type2diabeticpatientsundergoingcataractsurgeryinRajavithiHospitalfromJanuary2007toDecember2015.FifteenpatientswithPCEwereincludedasthecasegroupand179patientswithoutPCEwereincludedasthecontrolgroup.PotentialfactorsassociatedwithPCEamongbothgroupsincludingdemographics,pre-operativecharacteristics,surgicalsettingsandcomplications,werestatisticallyanalyzedusingChi-squaretestingandalogisticregressionmodel.RESULTS:Withinthecasegroup,53%werefemalesandthemedianagewas68y.Univariateanalysisofpre-operativecharacteristics,surgicalsettingsandcomplicationsrevealedthatrecentpre-operativefastingplasmaglucose,insulintherapy,presenceofdiabeticretinopathy,andseverenon-proliferativeorproliferativediabeticretinopathyweresignificantlyassociatedwithPCE.Inamultivariateanalysisadjustingforbloodglucoselevel,insulintreatmentwastheonlysignificantfactorassociatedwithanincreasedriskofPCE(OR3.9,95%CI1.0-15.0,P=0.04)comparedtopatientswithoutinsulintreatment.Themostcommoncausativeorganismsweregram-positivebacteria(89%).Staphylococcusspeciesrepresentedthemostcommongroup(67%).Medianbestcorrectedvisualacuityat1-monthand3-monthfollow-upwasequalat0.7logMAR(20/100).CONCLUSION:Theauthorsidentifyinsulintreatmentastheonlyriskfactorassociatedwithendophthalmitisaftercataractsurgeryintype2diabeticpatients.Furtherstudieswithserumlevelsofpre-operativeglycatedhemoglobin(HbA1c)andpost-operativefastingplasmaglucoselevelareessentialtotrulydemonstratetheroleofperi-operativeglycemicmarkersasariskfactorforPCE.

简介：AIMTo用光连贯断层摄影术(10月)并且到在奔流外科以后在糖尿病的眼睛估计斑点的量的变化估计开发的发生或有斑点的浮肿变得更坏(我)在糖尿病的眼睛与或没有先存在ME.METHODSIn这未来的、观察研究，经历了奔流外科的60个糖尿病的病人的92只眼睛在外科前被评估并且1，在用10月有斑点的厚度的外科以后的3mo在九有斑点的子字段与10月被测量定义b另外，开发的发生或我变得更坏在糖尿病的眼睛被分析与或没有先存在，ME.RESULTSThe中央子字段平均数厚度增加了21.0µ；m和25.5µ；在1点的m，3mo后续，分别地(P<；0.01)。内部戒指和外部戒指的平均厚度增加了14.2µ；m和9.5µ；在1mo的m，18.2µ；m和12.9µ；在3mo的m。中央包含我在3mo在12只眼睛发展了，包括4与先存在与先存在看中央包含和8只眼睛非中央包含了我。先存在的糖尿病的有斑点的浮肿(DME)显著地与中央包含被联系我开发(P<；0.001).CONCLUSIONA尽管增加是温和的，统计上重要的增加能在中央子字段以及perifoveal和parafoveal部门被检测。并且有在奔流外科以前的外科手术前的DME的眼睛在为开发中央包含的更高的风险我。

简介：DearEditor,WereadwithinteresttherecentlypublishedstudybyTriguerosetal~([1]),highlightingthefinancialandmanagementconditionsoffemtosecondlaser-assistedcataractsurgery(FLACS).Theauthorsderivedasimulationtoestimate

简介：AIMTo在一年后续上分析并且比较五个不同变量(1wk，1，3，6并且12mo)：线性测密度术珍视的前面的囊(交流)，和以后的囊(PC)区域测密度术值，交流和PC，和交流洞在femtosecond以后的区域减小比率帮助激光的奔流surgery.METHODSThis是未来的比较级学习。71个病人经历了femtosecond在2014年6月和2015年12月之间的单个眼睛上的帮助激光的奔流外科。5.0公里直径激光帮助了前面的capsulotomy在所有眼睛上被执行。在每外科以后的评估，交流opacificaction(ACO)和密度铺平的PCopacification(PCO)被OculusPentacam?HR使用区域和线性测密度术方法。数字图象与一个裂缝灯Topcon摄影照相机和IMAGEnet?被捕获5软件。数字图象上的交流洞区域用Sketchandcalc区域计算器被测量并且变换成减小比率levels.RESULTSUsing皮尔森关联系数(PCC)，我们没发现关联(r=-0.091，P=0.46)在在ACO的进化之间的第12个月评价，区域测密度术珍视，PCO区域测密度术珍视看作了独立变量。我们没发现关联，用PCC(r=-0.096，P=0.43)在ACO线性测密度术价值和PCO的进化之间，线性测密度术珍视在第12月访问，作为独立变量两个都工作。交流线性测密度术层次和交流区域测密度术层次继续从第六强烈成长到第12个月。交流空缺区域减小比率的价值的分析(1wk，1，3，6，12mo)揭示了连续考试的价值之间的统计上重要的差别，但是变化的大小减少了。在在六和12之间监视月的最后的时期，变化的大小是结果显示出的low.CONCLUSIONOur当capsulorhexis区域减小比率铺平时，ACO测密度术从第六珍视到第12个月的Scheimpflug的猛烈增加显示了可观的减少。我们没发现在ACO区域和PCO区域和线性测密度术价值之间的关联，在第12月考试，作为独立变量工作。

简介：AIMTo评估人的透镜上皮房间apoptosis并且对femtosecond激光在有到N3的N2的帮助奔流外科(FLACS).METHODSSixty奔流病人根据LOCSIII上演的femtosecond激光导致的间充质的转变(EMT)上皮在这研究被注册并且随机把组划分了成三：FLACS1组(由有LenSx的FLACS的奔流外科)，FLACS2组(由有LensAR的FLACS的奔流外科)和用手的组(由phacoemulsification的奔流外科)。在二个FLACS组的病人由LenSx或LensAR激光系统执行了前面的capsulotomy。在用手的组的病人被执行连续曲线的capsulorrhexis(CCC)手工地。恰好在从眼睛移动了以后，前面的囊被修理。在奔流surgery.RESULTSThe囊优势被病理学的染色在用手的capsulotomy在二个FLACS组和光滑的边看不规则和粗糙以后，染色的Hematoxylin-eosine，immunofluorescence染色和即时PCR被执行以便观察人的透镜上皮房间变化。有部分肿、破坏的原子核的房间配置的不规则在二个FLACS组被观察。Femtosecond激光能比手工地执行的CCC在人的透镜上皮房间导致显著地更高的房间apoptosis(P<0.05)。透镜上皮房间apoptosis根据皮尔森关联分析与femtosecond激光持续时间被相关。在二个FLACS组的减少的N-cadherin表示，alpha-SMA和FSP-1水平证明房间EMT.CONCLUSIONFemtosecond激光的抑制可以影响在剥的中央透镜囊下面的透镜上皮房间的apoptosis和EMT。

简介：AIMTo评估热门non-steroidal的预防管理的功效在糖尿病的病人的有斑点的浮肿追随者奔流外科上的反煽动性的药(NSAID)，并且在NSAID的类型之间比较(ketorolactromethamine0.4%并且nepafenac0.1%).METHODSGroup(控制)1作为一个安慰剂组接待了人工的眼泪代用品，(nepafenac)组2收到了热门nepafenac(ketorolac)0.1%，和组3收到了热门ketorolactromethamine0.4%。病人们在完成一个以后手术后地被检查为评估似胞的有斑点的浮肿(CME)的星期，一个月，二个月和三月间隔开发。主要学习结果在与光连贯地形学(10月)测量的中央有斑点的厚度(CMT)正在完成最好改正的视觉尖酸(BCVA)和变化76个病人的.RESULTSEighty眼睛在这研究被包括。BCVA在第三个月显示出统计上重要的差别手术后列在后面在上面在控制组和NSAID组(P=0.04)之间。在开始从的所有情况中的CMT有增加手术后第一个星期直到第三个月。CMT显示出控制组和NSAID组之间的统计上重要的差别从手术后第一个月直到第三个月(P=0.008，0.027，0.004)。在BCVA和外科手术前的10月CMT.CONCLUSIONProphylacticnepafenac和ketorolac组之间没有统计上重要的差别，手术后的NSAID可以在在跟随奔流外科的糖尿病的眼睛减少CME的频率和严厉有一个角色。

简介：AIM:ToinvestigatetheChineseversionoftheLowVisionQualityofLifeQuestionnaire(CLVQOL)asaninstrumentforobtainingclinicallyimportantchangesaftercataractsurgery.METHODS:PatientsunderwentcataractsurgeryinShanghaiGeneralHospital,ShanghaiJiaoTongUniversity,whofittheinclusioncriteriawererecruited.TwoCLVQOLswereadministered,includingapreoperativeCLVQOLandaCLVQOLattheendofthe3mofollow-upperiod,andwerecompletedusingface-to-faceinterviewsorphoneinterviewsconductedbytrainedinvestigators.Theminimalclinicallyimportantdifference(MCID)wascalculatedusingananchor-basedmethodandadistributionmethod.Inaddition,theresponsivenessofthequestionnairewasmeasured.RESULTS:Atotalof155residentswereenrolled.Theaveragevisualacuity(VA)preoperativelywas0.08(SD=0.05),anditincreasedto0.47(SD=0.28)attheendoffollowup.StatisticallysignificantpositivechangesintheCLVQOLscoresindicatedsignificantimprovementofvisionrelatedqualityoflifeaftercataractsurgery.Withthelargervaluebetweenthetworesultsasthefinalvalue,theMCIDvaluesoftheCLVQOL(scoresofthefourscalesaswellasthetotalscore)were8.94,2.61,4.34,3.10and17.63,respectively.TheCLVQOLhasbothgoodinternalandexternalresponsiveness.CONCLUSION:CLVQOLscoresareappropriateinstrumentsforobtainingclinicallyimportantchangesaftercataractsurgery.Thisstudyisaneffectiveexplorationforestablishingcataractsurgeryefficacystandards,whichhelpsclinicalandscientificresearchworkersinophthalmologytogainamorein-depthunderstandingwhenusingCLVQOL.

简介：AIMTo比较fluorometholone的联合0.1%并且0.5%在控制发炎并且与intraocular透镜implantation.METHODSSixty在phacoemulsification以后阻止感染掉到tobramycin/dexamethasone眼睛的levofloxacin从60看经历奔流phacoemulsification的病人被使随机化进二个组；病人的一半与与levofloxacin(4times/d)相结合的fluorometholone(6times/d)被对待，当另外的一半与眼睛掉一个星期的tobramycin/dexamethasone(4times/d)被对待时。在操作和1wk追随者treatments.RESULTSThere不是在角膜的厚度(P0.629)的二个组之间的统计上重要的差别以前，外科手术前、手术后的intraocular压力，水的闪光，角膜的厚度，和症状被记录，水的闪光(P0.398)，并且症状分数(P0.350)在每次指。眼睛的高血压仅仅在与levofloxacin治疗表演相结合的tobramycin/dexamethasonegroup.CONCLUSIONFluorometholone在二只眼睛被观察可比较的功效但是没有增加intraocular压力的趋势；因此，它可能是为手术后的使用的更好的政体。