简介：TheShanghaiCooperationOrganization(SCO)hasscoredgreatachievementssinceitsinceptioninthecooperationamongitsmemberstatesinthesecurity,economic,culturalandotherfieldsundertheguidanceoftheShanghaiSpirit.Asanewregionalorganization,theSCOhassetupamodelofnew-type

简介：AbstractBackground:Social Innovation in health initiatives have the potential to address unmet community health needs. For sustainable change to occur, we need to understand how and why a given intervention is effective. Bringing together communities, innovators, researchers, and policy makers is a powerful way to address this knowledge gap but differing priorities and epistemological backgrounds can make collaboration challenging.Main text:To overcome these barriers, stakeholders will need to design policies and work in ways that provide an enabling environment for innovative products and services. Inherently about people, the incorporation of community engagement approaches is necessary for both the development of social innovations and accompanying research methodologies. Whilst the 'appropriate' level of participation is linked to intended outcomes, researchers have a role to play in better understanding how to harness the power of community engagement and to ensure that community perspectives form part of the evidence base that informs policy and practice.Conclusions:To effectively operate at the intersection between policy, social innovation, and research, all collaborators need to enter the process with the mindset of learners, rather than experts. Methods - quantitative and qualitative - must be selected according to research questions. The fields of implementation research, community-based participatory research, and realist research, amongst others, have much to offer. So do other sectors, notably education and business. In all this, researchers must assume the mantel of responsibility for research and not transfer the onus to communities under the guise of participation. By leveraging the expertise and knowledge of different ecosystem actors, we can design responsive health systems that integrate innovative approaches in ways that are greater than the sum of their parts.

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简介：Inthispaper,someteststatisticsOfKolmogorovtypeandCramervonMisestypebasedonprojectionpursuittechniqueareproposedfortestingthesphericityproblemofahigh-dimensionaldistribution.Thelimitingdistributionsoftheteststatisticsarederivedunderthenullhypothesis.TheasymptoticpropertiesofBootstrapapproximationareinvestigatedandthetailbehaviorsofthestatisticsarestudied.

简介：Therehavebeenexponentialgainsinimmuno-oncologyinrecenttimesthroughthedevelopmentofimmunecheckpointinhibitors.AlreadyapprovedbytheU.S.FoodandDrugAdministrationforadvancedmelanomaandnon-smallcelllungcancer,immunecheckpointinhibitorsalsoappearstohavesignificantantitumoractivityinmultipleothertumortypes.Anexcitingcomponentofimmunotherapyisthedurabilityofantitumorresponsesobserved,withsomepatientsachievingdiseasecontrolformanyyears.Nevertheless,notallpatientsbenefit,andeffortsshouldthusnowfocusonimprovingtheefficacyofimmunotherapythroughtheuseofcombinationapproachesandpredictivebiomarkersofresponseandresistance.Therearemultiplepotentialrationalcombinationsusinganimmunotherapybackbone,includingexistingtreatmentssuchasradiotherapy,chemotherapyormolecularlytargetedagents,aswellasotherimmunotherapeutics.Theaimofsuchantitumorstrategieswillbetoraisethetailonthesurvivalcurvebyincreasingthenumberoflongtermsurvivors,whilemanaginganyadditiveorsynergistictoxicitiesthatmayarisewithimmunotherapycombinations.Rationaltrialdesignsbasedonaclearunderstandingoftumorbiologyanddrugpharmacologyremainparamount.Thisarticlereviewsthebiologyunderpinningimmuno-oncology,discussesexistingandnovelimmunotherapeuticcombinationscurrentlyindevelopment,thechallengesofpredictivebiomarkersofresponseandresistanceandtheimpactofimmuno-oncologyonearlyphaseclinicaltrialdesign.

简介：Amethodologyisimplementedtofindtheoptimumreducedweightconfigurationdesignofanoperatingstructureofacivilaircraftverticaltailfin.FE(finiteelement)basedtopologyoptimizationisexecutedtofindtheoptimummaterialdistributionofinitialdesignspaceofribbymaximizingthestiffness.Loadspertinenttotheoperatingandgroundconditionsareestimatedandapplied,consideringtheorientationofstructuralassemblymembersandbuilt-insupportsofferedinthemainstructure.Manufacturingconstraintsareincorporatedintotheoptimizationlooptogeneratepragmaticandmanufacturabledesignconfiguration.ThetopologicallyoptimizedconfigurationisthenconvertedtoCADviabledesignthroughdatareductionandsmoothingbyconvertingtoISO-surfaces.Amethodologyisalsodevisedtomodifythetopologicaloptimizedvoidsandmateriallayoutpreciselywithsplinesandfilletstoconstructmanufacturablefeaturesandavoidstressconcentrations.Theresultingnoveldesignproposalisthenanalyzedandvalidatedagainststipulatedloads,constraintsandotherdesignneeds.Resultsvalidatethenewdesignproposalasmorereliable,havingreducedweightandenhancedstructuralperformance.

简介：ThePSAunitfortreatingtherectificationtailgashasbeensuccessfullyputonstreamattheChloroalkaliStockCompany,Ltd.undertheShanmaGroup.Thetailgasthatwaspreviouslydirectlyventedintotheatmosphereiscurrentlybeingrecoveredandseparatedbythesaidunitwiththenontoxicfractionbeingventedintotheairandtherawacetyleneand

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简介：GeoscienceinstructioninIndiaisfacingaseriouscrisis-instancesareknownofwell-establisheduniversitygeologydepartmentswithmorethanascoreofseniorteachershavingjustacoupleofM.Sc.students.Thisprofoundlackofdemandforgeosciencestudiesisadirectconsequenceofthepaucityofemploymentopportunitiesfortradition-ally-trainedgeosciencegraduateswhich

简介：“Broad-way(百老汇)”是世界上最出名的大街之一，也是最长的一条街。它从纽约市的曼哈顿岛南端开始，向北一直延伸240公里，终于纽约州的首府奥尔巴尼。

简介：Themodulationinstabilityofquasi-plane-waveopticalbeamsisinvestigatedintheframeofgeneralizedSchrodingerequationwiththenonlineartermofageneralform.Generalexpressionsarederivedforthedispersionrelation,thecriticaltransversespatialfrequency,aswellastheinstabilitygrowthrate.Theanalysisgeneralizestheknownresultsreportedpreviously.Adetaileddiscussiononthemodulationinstabilityinbiasedcentrosymmetricphotorefractivemediaisalsogiven.

简介：大多数淡水鱼擅长转演习。一个模仿的鱼尾巴模型数字地详细被调查并且讨论。这研究处理在鱼尾巴鳍上施加在的不稳定的力量和时刻一起始斜着，击和随后的回来击打手势，并且设想流动领域和旋涡结构，鱼打手势以便探索典型拐弯处的流动控制机理。在相应于在它的C开始的鱼尾巴鳍的二张不同弯曲表格的动态后果被给的液体上推进讨论。Thetwo维的不稳定的不可压缩的海军司烧方程与一个developedpseudo压缩的可能性方法被解决在鱼尾巴鳍附近模仿流动。有实验的计算结果和比较显示那(1)钓鱼用过程展览的往来活动的中风，和每个阶段生产的冲动的时刻执行它的身体的一个转弯的运动它的特定的水动力学特征，(2)鱼采用尾巴尖端拐弯(单个拐弯和两倍拐弯)的二张表格完成C开始拐弯处演习，在他们的物理状况和自然环境的依赖，(3)鱼能由modulating控制它的转弯的运动一些关键运动学的参数。

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简介：与宽广带宽、分叉的横梁照亮的燃烧思考栅栏的远地的紧张和衍射效率被调查。什么时候光谱这个事件的宽度和分叉随经常的精力增加，最大的紧张减少，和一半微笑在最大的紧张的e-2的宽度变得更宽。甚至当事件光包含大量波长并且来自大量角度时，衍射效率没与合适的沟形状为燃烧栅栏有恶化。

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简介：China’sethyleneoxideindustryanditsdeepprocessingsectorareexperiencingaquickdevelopmentphasewithbroadprospectsforthedevelopmentoftheirdesignatedchemicalsmarket.In2006theEOproductioncapacityinChinahad

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简介：Thispaperaddsanegativevelocityfeedbacktothedynamicalsystemoftwin-tailaircrafttosuppressthevibration.Thesystemisrepresentedbytwocoupledsecond-ordernonlineardifferentialequationshavingbothquadraticandcubicnonlinearities.Thesystemdescribesthevibrationofanaircrafttailsubjectedtobothmulti-harmonicandmulti-tunedexcitations.Themethodofmultipletimescaleperturbationisadoptedtosolvethenonlineardifferentialequationsandobtainapproximatesolutionsuptoth...

简介：Wefirstreportafabricationtechniqueofnanoscalespecklepatternsonpolymersusingbroadionbeammilling.Theproposedtechniqueissimpleandlow-costtoproducespecklesrangingfromdozensofnanometerstolessthanthreemicrometersinalargeareaofseveralmillimeters.Randompatternsweresuccessfullyproducedwithanargon(Ar)ionbeamonthesurfacesoffourkindsofpolymers:theepoxymatrixofcarbonfiberreinforcedplastic,polyester,polyvinylformal-acetal,andpolyimide.Thespecklemorphologiesslightlyvarywithdifferentpolymers.Thefabricatedspecklepatternshavegoodtimestabilityandarepromisingtobeusedtomeasurethenanoscaledeformationsofpolymersusingthedigitalimagecorrelationmethod.