简介:Basedonthefirstlawofthermodynamicsandthethermaldiffusionequation,thededucedtheoreticalmodelofmitochondrialthermogenesissatisfiestheLaplaceequationandisaspecialcaseofthethermaldiffusionequation.Themodelsettlesthelong-standingquestionoftheabilitytoincreasecellulartemperaturebyendogenousthermogenesisandexplainsthethermogeniccharacteristicsofbrownadipocytes.Themodelandcalculationsalsosuggestthatthenumberoffreeavailableprotonsisthemajorlimitingfactorforendogenousthermogenesisanditsspeed.