简介：AbstractSevere fever with thrombocytopenia syndrome (SFTS) was first detected in China in 2009. The incidence of SFTS increases year by year, and there is no effective treatment. Considering that the reported prevalence of SFTSV infection varies from region to region, we aimed to quantitatively evaluate the epidemic characteristics of SFTSV infection in China from 2010 to 2020, including the distribution differences in infectious season, sex, age, occupation, and region. A meta-analysis framework was used to search for the related published data with keywords in electronic databases (CNKI, WanFang, CBM, and PubMed). According to the PRISMA statement, the studies that included SFTS diagnosed in China were analyzed. Furthermore, we used Revman and Stata to merge statistical effects, and used I2 and P-values for heterogeneity test and quality assessment. Eleven studies containing 4,932 cases confirmed by SFTSV infection were included in this meta-analysis. The ratio of male-to-female is 1.04 to 1. Cases were concentrated between 40 and 80 years of age (MD = 92%, 95%CI: 91%-93%). Farmers are at the highest risk of SFTSV infection (MD = 84%, 95%CI: 77%-90%). The risk of infection for consecutive period of April-August was significantly higher than the sum of the remaining months (MD = 82%, 95%CI: 78%-85%). In addition, the patient has an extensive history of exposure, including living in the mountains, exposure to ticks, livestock, mouse and the patient. We came to the conclusion that SFTSV is transmitted primarily through tick bites in China, so middle-aged and older adults living in mountains regions are at the highest risk for SFTSV infection in April through August each year.

简介：AbstractBackground:The transmission and fatal risk of severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease first discovered in China in 2009, still needed further quantification. This research aimed to analyze the SFTS clusters and assess the transmission and mortality risk for SFTS.Methods:Both epidemiological investigation and case reports regarding SFTS clusters in China during 2011-2021 were obtained from the Public Health Emergency Information Management System of the Chinese Center for Disease Control and Prevention Information System. The transmission risk was evaluated by using the secondary attack rate (SAR) and relative risk (RR). Mortality risk factors were analyzed using a logistic regression model.Results:There were 35 SFTS clusters during 2011-2021 involving 118 patients with a fatality rate of 22.0%. The number of clusters annually increased seasonally from April to September. The clusters mainly occurred in Anhui (16 clusters) and Shandong provinces (8 clusters). The SAR through contact with blood or bloody fluids was much higher than that through contact with non-bloody fluids (50.6% vs 3.0%; χ2 = 210.97, P < 0.05), with an RR of 16.61 [95% confidence interval (CI): 10.23-26.97]. There was a statistically significant difference in the SAR between exposure to the blood of a deceased person during burial preparation and exposure to the living patients’ blood (66.7% vs 34.5%; χ2= 6.40, P < 0.05), with an RR of 1.93 (95% CI: 1.11-3.37). The mortality risk factors were a long interval from onset to diagnosis [odds ratio (OR)= 1.385), 95% CI: 1.083-1.772, P= 0.009) and advanced age (OR: 1.095, 95% CI: 1.031-1.163, P= 0.01).Conclusions:The SFTS clusters showed a high mortality rate and resulted in a high SAR. Contact with a bleeding corpse was associated with a higher infection risk, compared with contacting the blood from living patients. It is important to promote early detection and appropriate case management of patients with SFTS, as well as improved handling of their corpses, to prevent further transmission and mortality.

简介：客观：与严重煽动性的反应症候群(先生)在创伤的病人调查甲状腺荷尔蒙的引申。方法：有严重先生的五十个创伤的病人被注册并且根据他们是否介绍了multiorgandysfunction症候群(MODS)把组划分了成二。甲状腺荷尔蒙大小被拿，包括totaltriiodothyronine(TT3)，全部的甲状腺素(TT4)，免费triiodothyronine(FT3)，免费甲状腺素(FT4)和甲状腺刺激荷尔蒙(TSH)。尖锐生理学和长期的健康评估Ⅱ(APACHEⅡ)20根据临床的数据被计算。恢复或恶化的结果被记录，以及从到时间甲状腺荷尔蒙的先生的发作的时间的长度被测量。结果：Euthyroid病了的症候群(S字)在45cases.TT3水平被介绍否定地与APACHEH分数被相关(r=-0.330,P<0。05)，并且TT3/TT4value否定地与先生的持续时间被相关(r=-0.316,P<0.05)。没有MODS，在MODS病人的TT3，TT4和FT3levels是比那些显著地低的(P<0.05)。没有MODS，给低TT4或FT4的MODS病人比那些经常铺平更多(P<0.05)。与在正常TSH组的病人相比，有有的减少的TSH的病人降低T3，T4，恢复率和更高的APACHEⅡ分数，MODS发生，但是二个组之间没有差别(P>0.05).Conclusions：有严重先生的损伤病人有高可能性得到S字，它更经常并且严重地发生在MODS病人。它在甲状腺轴上显示出先生的影响。Withthe坚持和先生的恶化，有甲状腺荷尔蒙的进步减小。

简介：AbstractPeriodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is the most common periodic fever condition in children, with most cases appearing by the age of 5. Although PFAPA is generally a self-limited condition, it can have a major impact on a child’s quality of life, as well as that of their family. Recent research has continued to shed light on the genetic and immunologic factors that play a role in the pathogenesis of PFAPA. There also exists significant heterogeneity in treatment strategies, and progress has been made to develop evidence-based management strategies and establish a standard of care. This review will outline current knowledge regarding the pathogenesis of PFAPA, as well as treatment strategies and our clinical experience.

简介：AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced multisystem inflammatory syndrome in children (MIS-C) is a life-threatening illness that has been reported in the United States and Europe. It affects multiple organ systems and often requires patient admission to an intensive care unit. Although some features of MIS-C overlap with Kawasaki disease, MIS-C is more common among older children and adolescents, more often affects cardiovascular and gastrointestinal systems, and more frequently presents with elevated inflammatory markers. Rapid and complete clinical recovery is possible in nearly all patients following immunomodulation therapy. Thus far, MIS-C pathophysiology and long-term prognosis are not sufficiently clear; further studies are needed.

简介：BackgroundThrombocytopeniaisacommoncomplicationofIABP.Untilnow,thereisnounifiedconclusionsabouttheincidence,characteristics,riskfactorsandtheprognosisofIABPrelatedthrombocytopenia.MethodsInthisstudy,thedataofpatientswithACSundergoingPCIandIABPwereretrospectivelyanalyzed.Allenrolledpatientsweredividedintothrombocytopeniagroupandnon-thrombocytopeniagroupaccordingtotheoccurrenceofthrombocytopeniaafterinsertionofIABP.Thebaselinedataofthetwogroupswerecompared,andthepossibleriskfactorsofthrombocytopeniaandtheirimpactonprognosiswereanalyzedbychi-squaretestandlogisticregressionanalysis.ResultsSixty-twopatientswereenrolledinthisstudy.TherateofIABPassociatedthrombocytopeniawas25.8%(16/62)ofallpatients.OlderagewasanindependentriskfactorofIABPassociatedthrombocytopenia(OR:3.625;95%confidenceinterval:1.016-12.935;P=0.047).TheincidenceofTIMIbleedingeventswashigherinthrombocytopeniagroup[75.0%(12/16)vs.43.5%(20/46),P=0.042].Therateofin-hospitaldeathwassimilarbetweenthetwogroups[18.8%(3/16)vs.17.4%(8/46),P=1.0].ConclusionIABPassociatedthrombocytopeniaoccursin25.8%ofpatientswithACSundergoingPCIandcorrelateswithincreasedTIMIbleedingevents.OlderagemaypredictIABPassociatedthrombocytopenia.

简介：AbstractPurpose:There are many infectious and inflammatory causes for elevated core-body temperatures, though they rarely pass 40 ℃ (104 ℉). The term "quad fever" is used for extreme hyperpyrexia in the setting of acute cervical spinal cord injuries (SCIs). The traditional methods of treating hyperpyrexia are often ineffective and reported morbidity and mortality rates approach 100%. This study aims to identify the incidence of elevated temperatures in SCIs at our institution and assess the effectiveness of using a non-invasive dry water temperature management system as a treatment modality with mortality.Methods:A retrospective analysis of acute SCI patients requiring surgical intensive care unit admission who experienced fevers ≥ 40 ℃ (104 ℉) were compared to patients with maximum temperatures < 40 ℃. Patients ≥18 years old who sustained an acute traumatic SCI were included in this study. Patients who expired in the emergency department; had a SCI without radiologic abnormality; had neuropraxia; were admitted to any location other than the surgical intensive care unit; or had positive blood cultures were excluded. SAS 9.4 was used to conduct statistical analysis.Results:Over the 9-year study period, 35 patients were admitted to the surgical intensive care unit with a verified SCI. Seven patients experienced maximum temperatures of ≥ 40 ℃. Six of those patients were treated with the dry water temperature management system with an overall mortality of 57.1% in this subgroup. The mortality rate for the 28 patients who experienced a maximum temperature of ≤ 40 ℃ was 21.4% (p = 0.16).Conclusion:The diagnosis of quad fever should be considered in patients with cervical SCI in the presence of hyperthermia. In this study, there was no significant difference in mortality between quad fever patients treated with a dry water temperature management system versus SCI patients without quad fever. The early use of a dry water temperature management system appears to decrease the mortality rate of quad fever.

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简介：TheZ10andZ37strainsofhemorrhagicfeverwithrenalsyndrome(HFRS)virusandtheMongoliangerbil(Merionsunguiculatus)kidneycellswereusedtopreparetheinactivatedbivalentvaccine.AphaseⅡclinicaltrialuseofthisvaccinewasmadein750Chinesevolunteers.Theresultsshowedthatthesidereactionratewas2.5%andthesero-conversionrateofneutralizingantibodiesagainstHantaanandSeoulvirusesintheinoculatedvolunteerswere87.6%and96.3%respectively.

简介：Thesuddenoutbreakofsevereacuterespiratorysyndrome(SARS)in2002promptedtheestablishmentofaglobalscientificnetworksubsumingmostofthetraditionalrivalriesinthecompetitivefieldofvirology.WithinmonthsoftheSARSoutbreak,collaborativeworkrevealedtheidentityofthedisastrouspathogenasSARS-associatedcoronavirus(SARS-CoV).However,althoughtherapididentificationoftheagentrepresentedanimportantbreakthrough,ourunderstandingofthedeadlyvirusremainslimited.Detailedbiologicalknowledgeiscrucialforthedevelopmentofeffectivecountermeasures,diagnostictests,vaccinesandantiviraldrugsagainsttheSARS-CoV.ThisarticlereviewsthepresentstateofmolecularknowledgeaboutSARS-CoV,fromtheaspectsofcomparativegenomics,molecularbiologyofviralgenes,evolution,andepidemiology,anddescribesthediagnostictestsandtheanti-viraldrugsderivedsofarbasedontheavailablemolecularinformation.

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简介：AbstractSince December 2019, increasing attention has been paid to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Wuhan, China. SARS-CoV-2 primarily invades the respiratory tract and lungs, leading to pneumonia and other systemic disorders. The effect of SARS-CoV-2 in transplant recipients has raised significant concerns, especially because there is a large population of transplant recipients in China. Based on the current epidemic situation, this study reviewed publications on this virus and coronavirus disease 2019 (COVID-19), analyzed common features of respiratory viral pneumonias, and presented the currently reported clinical characteristics of COVID-19 in transplant recipients to improve strategies regarding the diagnosis and treatment of COVID-19 in this special population.

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简介：Inordertoelucidatethemolecularandimmunologicalmechanismsaswellasthepathogenesisofhemorrhagicfeverwithrenalsyndrome(HFRS),theCD8^+cytotoxicTlymphecytes(CTL)clonewasestablisheddirectlyfromperipheralbloodmononuclearcells(PBMC)ofpatientswithHFRS.TheactivitiesofCTLweredetectedasusualwithEBV-transformedlymphoblastoidcellline(BLCL)astargetcells.TheresultsshowedthattheCTLclonecouldrecognizedandkilledthetargetcellswithspecificityofnucleocapsidproteinofHantaanvirus(HTNVNP)withthecytotoxicitypercentagesof50.2%,25.4%and39.0%respectively.TheseresultsdemonstratedthattheantigenicepitopesofHTNVNPmainlylocatedontheC-temainaloftheviralnucleocapsidprotein.

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简介：Theinitialassessmentoftravellersisaimedprimarilyatearlydetectionandtreatmentofmalaria(seepage32),whichcanberapidlyfatal.

简介：AcuterheumaticfeverisinitiatedbygroupAstreptococcalphar-yngitis.Thisisfollowedbyalatentperiodof2-6weeks,afterwhichtheclinicalsyndromeofacuterheumaticfeverevolves,characterizedbypolyarthritis,carditis,chorea,erythemamarginatumandsubcutaneousnodules.Thesefeaturesmayoccursinglyorinanycombination.

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