简介:SNDisasphericalnon-magneticdetectoroperatingsince1996atVEPP-2Melectron-positroncolliderinNovosibirsk,SNDisperforminganupgradeofitssubsystems,electronics,andsoftwareforthenextrunatVEPP-2000,PresentFortran-basedofflineprogramswillbereplacedwiththeobject-orientedframework,whichsupportssimulation,reconstructionandanalysisactivities,Newframeworkexploitstheexperienceobtainedintheworkwiththecurrentofflineandsupportsorextendsitsessentialfeatures.Themainframeworkconceptisamodule,whichisabasicprocessingunitconsumingsomedataandproducingnewdata.Everymodulecanbeparameterizedduringruntime.Formalizeddescriptionofthemodulesisusedbytheframeworksequencerfortheselectionandorderingofminimalsubsetofmodulesforanygiventask.Datapersistencyservicesaremadesufficientlyabstracttoallowimplementationfordifferentpersistencytechnologies.Prsentlythereisanimplementationforthesequentialfileswithpackeddata.Theframeworkprovidesaninterfaceforscriptinglanguages.Togetherwithacustomexpressionparserthisgivesasupportforextensiblerun-timehistogramming.ThefunctionalprototypeoftheframeworkwasimplementedinPythonlanguageandprovedtheconceptsoftheproject.CurrentlythisprototypeisbeingreimplementedinC++.
简介:SNDisasphericalnon-magneticdetector,whichoperatedsince1996atVEPP-2Melectron-positroncolliderinNovosibirsk.NowVEPP-2McolliderisdismantledtobereplacedbyanewVEPP-2000machinewithhigherenergyandluminosity.TheSNDdetectorisalsoperformingupgradeofitssubsystemsincludingelectronics,andsoftware,ExpectedsubstantialgrowthofeventsdataflowrequiresradicalchangesintheDataAcquisition(DAQ)systemsoftware.ThispaperdescribestheSND2000softwarearchitecrureanditsprincipalcomponents.Firstthemaineventsflowprocessuingcomponentsareconsidered-thereadoutprocessandtheL3-triggerfarm.AfterprocessingbyL3theeventsflowiseitherloggedtotapeorfedtocalibrationandslowcontrolprocess.Usingauxiliarycontrolandservicesoftwarecomponents,whicharealsodescribed.performsthemanagementoftheseactivities.
简介:AbstractBackground:The pathogenesis of osteosarcoma (OS) is still unclear, and it is still necessary to find new targets and drugs for anti-OS. This study aimed to investigate the role and mechanism of the anti-OS effects of miR-296-5p.Methods:We measured the expression of miR-296-5p in human OS cell lines and tissues. The effect of miR-296-5p and its target gene staphylococcal nuclease and tudor domain containing 1 on proliferation, migration, and invasion of human OS lines was examined. The Student’s t test was used for statistical analysis.Results:We found that microRNA (miR)-296-5p was significantly downregulated in OS cell lines and tissues (control vs. OS, 1.802 ± 0.313 vs. 0.618 ± 0.235, t= 6.402, P < 0.01). Overexpression of miR-296-5p suppressed proliferation, migration, and invasion of OA cells. SND1 was identified as a target of miR-296-5p by bioinformatic analysis and dual-luciferase reporter assay. Overexpression of SND1 abrogated the effects induced by miR-296-5p upregulation (miRNA-296-5p vs. miRNA-296-5p + SND1, 0.294 ± 0.159 vs. 2.300 ± 0.277, t= 12.68, P = 0.003).Conclusion:Our study indicates that miR-296-5p may function as a tumor suppressor by targeting SND1 in OS.
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简介:首先分析了便携式MP3播放器的工作原理及其系统构成,接着介绍了一种基于51单片机的MP3播放器设计方案。采用AT89C51SND1C单片机,其片内集成了MP3解码器,使用K9F1208闪存作为外存储器,放音电路采用CS4330,音乐文件通过播放器上的USB接口从PC机上直接下载。该方案设计简单,性价比高、低功耗、易扩展。