简介：ThispaperisdevotedtoproblemsstatedbyZ.ZhouandF.Liin2009.Theyconcernrelationsbetweenalmostperiodic,weaklyalmostperiodic,andquasi-weaklyalmostperiodicpointsofacontinuousmapfanditstopologicalentropy.Thenegativeanswerfollowsbyourrecentpaper.Butforcontinuousmapsoftheintervalandothermoregeneralone-dimensionalspaceswegivemoreresults;insomecasestheanswerispositive.

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简介：Primarysclerosingcholangitis（PSC）isachronicprogressiveinflammatorydiseaseaffectingthebileducts,leadingtofibrosisandeventuallycirrhosisinmostpatients.Itsetiologyisunknownandsofarnoeffectivemedicaltherapyisavailable.Livertransplantation（LTX）istheonlycurativetreatmentandatpresentPSCisthemainindicationforLTXintheScandinaviancountries.ClosetohalfofthePSCpatientsexperienceoneormoreepisodesofacutecellularrejection（ACR）followingtransplantationandapproximately1/5ofthetransplantedpatientsdeveloprecurrentdiseaseinthegraft.Inaddition,somereportsindicatethatACRearlyafterLTXforPSCcaninfluencetheriskforrecurrentdisease.Fortheseimportantpost-transplantationentitiesaffectingPSCpatients,wehavereviewedthecurrentliteratureonepidemiology,pathogenesis,treatmentandthepossibleinfluenceofrejectionontheriskofrecurrentdiseaseintheallograft.

简介：AdegreeelevationformulaformultivariatesimplexsplineswasgivenbyMicchelli[6]andextendedtoholdformultivariateDirichletsplinesin[8].Wereportsimilarformulaeformultivariateconesplinesandboxsplines.Tothisend,weutilizearelationduetoDahmenandMicchelli[4]thatconnectsboxsplinesandconesplinesandadegreereductionformulagivenbyCohen,Lyche,andRiesenfeldin[2].

简介：Middleearsurgerytechniqueshaveenabledtoimprovehearingdestroyedbyadisease.Despitehugeimprovementininstrumentationandtechniquestheresultsofhearingimprovementsurgeryarestilldifficulttopredict.ThispaperpresentstheresultsofvibrationsmeasurementsinahumanmiddleearobtainedattheMedicalUniversityofLublin.Vibrationsofthestapesinthecaseoftheintactossicularchain,aftercementincusrebuildingandincusinterpositionsarecomparedeachother.Inthisaimanewapproachofossiclesvibrationsobservationisintroducedinordertocompleteinformationobtainedfromclassicalapproachwhichbasesonthetransferfunction.Measurementsofossicularchainvibrationsareperformedonfreshhumantemporalbonespecimenusingthelaserdopplervibrometer.Next,afterclassicalresearch,theextendedanalysiswiththerecurrenceplotstechniqueisperformed.

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简介：AbstractBackground:The standard treatment for pediatric differentiated thyroid carcinoma (DTC) still requires consideration because of a lack of clinical evidence. The purpose of this study was to summarize the clinical experiences and explore the risk factors for post-operative recurrence through a retrospective analysis to develop better clinical strategies for pediatric DTC.Methods:This study retrospectively analyzed children and adolescents with DTC who were treated between January 1999 and December 2014 at the Cancer Hospital, Chinese Academy of Medical Sciences. Clinicopathological results and outcomes were collected. A log-rank test of Kaplan-Meier curves and the Cox regression model were used to determine the factors associated with recurrence.Results:Data of 150 patients were collected in this study. During the follow-up, there was only one disease-related death. The recurrence rates at 3, 5, and 10 years were 13.6%, 18.7%, and 28.6%, respectively. There was a significant difference in the rate of recurrence according to age (P < 0.001), extrathyroidal extension (P < 0.001), lymph node metastasis (P = 0.023), and invasion of the trachea and esophageal wall (P = 0.004). Cox regression analysis demonstrated that age (P = 0.006) and extrathyroidal extension (P = 0.013) were significant dependent factors of post-operative recurrence.Conclusions:The prognosis of DTC in children and adolescents is favorable. A close follow-up is recommended because of the high recurrence rate. A comparatively higher recurrence rate was observed in the younger age group, and new age-based divisions may be needed to conveniently evaluate the possibility of recurrence.

简介：ThispapergivesanadditionaldefinitiontomultivariatetruncatedpowerT(x|x1,…,xn)whentheknotsx1,…,xndonotspanthewholespacetowhichx1,…,xnbelong.Bywhich,togetherwiththerecurrencerelation,thepracticalevaluationofT(x|x1,…,xn)willbeveryconvenientandefficient.Thesamediscussionisalsodonetoboxsplines.

简介：Objective:Theaimofthepresentstudywastoconstructariskassessmentmodelwhichwastestedbydisease-freesurvival(DFS)ofesophagealcancerafterradicalsurgery.Methods:Atotalof164consecutiveesophagealcancerpatientswhohadundergoneradicalsurgerybetweenJanuary2005andDecember2006wereretrospectivelyanalyzed.Thecutpointofvalueatrisk(VaR)wasinferredbystem-and-leafplot,aswellasbyindependent-samplest-testforrecurrence-freetime,furtherconfirmedbycrosstabchi-squaretest,univariateanalysisandCoxregressionanalysisforDFS.Results:ThecutpointofVaRwas0.3onthebasisofourmodel.Therateofrecurrencewas30.3%(30/99)and52.3%(34/65)inVaR<0.3andVaR≥0.3(chi-squaretest,χ2=7.984,P=0.005),respectively.The1-,3-,and5-yearDFSofesophagealcancerafterradicalsurgerywas70.4%,48.7%,and45.3%,respectivelyinVaR≥0.3,whereas91.5%,75.8%,and67.3%,respectivelyinVaR<0.3(Log-ranktest,χ2=9.59,P=0.0020),andfurtherconfirmedbyCoxregressionanalysis[hazardratio=2.10,95%confidenceinterval(CI):1.2649-3.4751;P=0.0041].Conclusions:Themodelcouldbeappliedforintegratedassessmentofrecurrenceriskafterradicalsurgeryforesophagealcancer.

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简介：我们沿着Kefallinia变换检验了二个差错地区的整个强烈地震复发行为，爱奥尼亚的海，希腊，为时期与M5.5用地震学上的数据和统计methods.Our数据包括29个事件16362003。我们为Kefallinia差错地区发现了不同复发行为(聚类并且时间可预言的复发行为)并且Lefkada差错地区(近的随机和non-slip-predictable或non-timepredictable复发自然)。不同模式可以被归因于：由静态的被触发和(b)的(a)片断相互作用沿着罢工(Kefallinia)到Lefkada上的复发上的北方和东方的差错系统的影响。在活跃时期以内，地震复发间隔以一种更多的驱散的方式被散布，并且能被Weibull分布适合很好。相反，安静时期的分发少些相对被驱散并且困难由合适的概率功能描述。

简介：ＫｉｎｅｍａｔｉｃｆｅａｔｕｒｅｓｏｆｔｈｅｓｅｉｓｍｏｇｅｎｉｃｆａｕｌｔｏｆｔｈｅＴａｎｇｓｈａｎｅａｒｔｈｑｕａｋｅａｎｄｔｈｅｒｅｃｕｒｒｅｎｃｅｐｅｒｉｏｄｏｆｌａｒｇｅｅａｒｔｈｑｕａｋｅｓＪＩＥＬＩＵ１）（刘洁）ＨＵＩ－ＺＨＥＮＳＯＮ...

简介：AbstractBackground:Various prediction tools have been developed to predict biochemical recurrence (BCR) after radical prostatectomy (RP); however, few of the previous prediction tools used serum prostate-specific antigen (PSA) nadir after RP and maximum tumor diameter (MTD) at the same time. In this study, a nomogram incorporating MTD and PSA nadir was developed to predict BCR-free survival (BCRFS).Methods:A total of 337 patients who underwent RP between January 2010 and March 2017 were retrospectively enrolled in this study. The maximum diameter of the index lesion was measured on magnetic resonance imaging (MRI). Cox regression analysis was performed to evaluate independent predictors of BCR. A nomogram was subsequently developed for the prediction of BCRFS at 3 and 5 years after RP. Time-dependent receiver operating characteristic (ROC) curve and decision curve analyses were performed to identify the advantage of the new nomogram in comparison with the cancer of the prostate risk assessment post-surgical (CAPRA-S) score.Results:A novel nomogram was developed to predict BCR by including PSA nadir, MTD, Gleason score, surgical margin (SM), and seminal vesicle invasion (SVI), considering these variables were significantly associated with BCR in both univariate and multivariate analyses (P < 0.05). In addition, a basic model including Gleason score, SM, and SVI was developed and used as a control to assess the incremental predictive power of the new model. The concordance index of our model was slightly higher than CAPRA-S model (0.76 vs. 0.70, P = 0.02) and it was significantly higher than that of the basic model (0.76 vs. 0.66, P = 0.001). Time-dependent ROC curve and decision curve analyses also demonstrated the advantages of the new nomogram.Conclusions:PSA nadir after RP and MTD based on MRI before surgery are independent predictors of BCR. By incorporating PSA nadir and MTD into the conventional predictive model, our newly developed nomogram significantly improved the accuracy in predicting BCRFS after RP.

简介：Thestudyshowsthatearthquake-affectedtime-spacedomain(ETSD),i.e.atime-spacerangeinwhichstrongearthquakesareunabletooccurowingtotheinfluenceofapriorearthquakeoccurring,showsahyperbolicmargincurveinthet(time)-r(distance)coordinateplane,whichhasamaximumaffectedradiusr0att=0andamaximuminfluencetimet0(i.e.theinsiturecurrenceintervalofearthquakes)atr=0.Basedonthetime-distancedistributionsofposteriorearthquakesrelativetoproronesintheregionsofNorthChina,NorthwestChina,Qinghai-Xizang(Tibet)plateauandSouthwestChina,theoptimizedand90%-confidencemargincurvesareestimatedusingoptimizationandstatisticalanalysismethods.ThisindicatesthattheconceptandmethodofETSDwith3-dimension(time-distance-magnitudes)insteadofthoseof"recurrenceinterval"with1-dimension(time)or2-dimension(time-magnitude)providesanewapproachtounderstandingthefluctuationofseismicactivities,estimatingtheeffectiveearthquake-preparationtimeofpotentialhypocenters,andthereforeimprovingthemediumandlong-termpredictionofstrongearthquakes.

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简介：AbstractBackground:Degree of mucosal recovery is an important indicator for evaluating the therapeutic effects of drugs in treatment of inflammatory bowel disease (IBD). Increasing evidences has proved that tight junction (TJ) barrier dysfunction is one of the pathological mechanisms of IBD. The aim of this study was to observe whether enhancement of TJ can decrease colitis recurrence.Methods:Eighty C57BL/6 mice were randomly divided into four groups including normal group, colitis group, sulfasalazine (SASP) treated group, and traditional Chinese drug salvianolic acid B (Sal B) treated group. Colitis was established in mice by free drinking water containing dextran sulfate sodium, after treatments by SASP and Sal B, recombinant human interleukin-1β (IL-1β) was injected intraperitoneally to induce colitis recurrence.Results:Compared with sham control, cell apoptosis in colitis group was increased from 100.85 ± 3.46% to 162.89 ± 11.45% (P = 0.0038), and TJ dysfunction marker myosin light chain kinase (MLCK) was also significantly increased from 99.70 ± 9.29% to 296.23 ± 30.78% (P = 0.0025). The increased cell apoptosis was reversed by both SASP (125.99 ± 8.45% vs. 162.89 ± 11.45%, P = 0.0059) and Sal B (104.27 ± 6.09% vs. 162.89 ± 11.45%, P = 0.0044). High MLCK expression in colitis group was reversed by Sal B (182.44 ± 89.42% vs. 296.23 ± 30.78%, P = 0.0028) but not influenced by SASP (285.23 ± 41.04% vs. 296.23 ± 30.78%, P > 0.05). The recurrence rate induced by recombinant human IL-1β in Sal B-treated group was significantly lower than that in SASP-treated group.Conclusions:These results suggested a link between intestinal mucosal barrier dysfunction, especially TJ barrier dysfunction, and colitis recurrence. The TJ barrier dysfunction in remission stage of colitis increased the colitis recurrence. This study might provide potential treatment strategies for IBD recurrence.

简介：可移植的试验性的肿瘤模型被构造对肿瘤复发和转移学习recombinant人interleukin-15(rhIL-15)的活动。结果证明那肿瘤小瘤形成被延迟，肿瘤生长与rhIL-15在处理以后在LA795肺腺癌的下的肿瘤模型被禁止，并且与rhIL-15对待的T739忍受肿瘤的老鼠的幸存率比与盐的任何一个或与rhIL-2的一样的剂量对待的老鼠的高得多。这indicats那rhIL-15antitumor最好在一样的剂量水平比rhIL-2完成。在一些，rhIL-15对待老鼠，皮下地接种的肿瘤房间被根除，没有肿瘤形成甚至在肿瘤以后的138天房间接种。没有肿瘤的老鼠与实时肿瘤房间被重新质问，没有肿瘤这些老鼠在所有在下列二个月内重新发生，显示全身的免疫开发了的那长持续的antitumor。肿瘤复发和转移与rhIL-15，然而并非与rhIL-2的一样的剂量在处理以后显著地被禁止，这也被显示出，在LA795肺腺癌的皮下地并且静脉内地传播的肿瘤模型。同时，splenocytes的CTL和NK房间活动从与任何一个rhIL-15被对待的忍受肿瘤的老鼠获得了或rhIL-2是显著地提高的两个。然而，CTL和NK房间活动的改进在rhIL-15是更重要的在rhIL-2比那对待老鼠对待的老鼠。这建议在vivo的rhIL-15的反肿瘤效果被在肿瘤免疫者反应提高CTL和NK房间活动完成。细胞与分子的免疫学。2008；5(3):189-196。

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