简介:Inthe2016electionintheUnitedStates,non-traditionalcandidateslikeDonaldTrumpandBernieSandershaveemerged.Populism,counter-elitism,anti-intellectualsentimentsareontherampage.Theseeminglyirreversibleworldtrendofglobalizationhascomeunderdoubt.Ethnicconflictsandclasheswithpolicehavecausedaseriesofmassacres.Currently,theUSisonhighalert.
简介:Inthispaper,byusingtheGuo-Krasnoselskii'sfixed-pointtheorem,weestablishtheexistenceandmultiplicityofpositivesolutionsforafourth-ordernonlineareigenvalueproblem.Thecorrespondingexamplesarealsoincludedtodemonstratetheresultsweobtained.
简介:Inthispaper,weconsiderthefollowingproblem{-Δu(x)+u(x)=λ(u~p(x)+h(x)),x∈R~N,u(x)∈h~1(R~N),u(x)>0,x∈R~N,(*)whereλ>0isaparameter,p=(N+2)/(N—2).Wewillprovethatthereexistsapositiveconstant0λ*,auniquesolutionforλ=λ*.Furthermore,(*)possessesatleasttwopositivesolutionswhenλ∈(0,λ*)and3≤N≤5.ForN≥6,undersomemonotonicityconditionsofhweshowthatthereexistsaconstant0
简介:Inordertofurtherimprovethecarriersynchronizationestimationrangeandaccuracyatlowsignal-to-noiseratio(SNR),thispaperproposesacode-aidedcarriersynchronizationalgorithmbasedonimprovednonbinarylow-densityparity-check(NB-LDPC)codestostudythepolarization-division-multiplexingcoherentopticalorthogonalfrequencydivisionmultiplexing(PDM-CO-OFDM)systemperformanceinthecasesofquadraturephaseshiftkeying(QPSK)and16quadratureamplitudemodulation(16-QAM)modes.Thesimulationresultsindicatethatthisalgorithmcanenlargefrequencyandphaseoffsetestimationrangesandenhanceaccuracyofthesystemgreatly,andthebiterrorrate(BER)performanceofthesystemisimprovedeffectivelycomparedwiththatofthesystememployingtraditionalNB-LDPCcode-aidedcarriersynchronizationalgorithm.
简介:Byapplyingiterativetechnique,weobtaintheexistenceofpositivesolutionsforasingularRiemann-Stieltjesintegralboundaryvalueprobleminthecasethatf(t,u)isnon-increasingrespecttou.
简介:Carbonclothmodifiedbyhydrothermaltreatmentinammoniawaterisdevelopedasthepositiveelectrodewithhighelectrochemicalperformanceforvanadiumredoxflowbatteries.TheSEMshowsthatthetreatmenthasnoobviousinfluenceonthemorphologyofcarboncloth.XPSmeasurementsindicatethatthenitrogenousfunctionalgroupscanbeintroducedonthesurfaceofcarbonclothsuccessfully.TheelectrochemicalperformanceofV(IV)/V(V)redoxcoupleonthepreparedelectrodeisevaluatedwithcyclicvoltammetryandlinearsweepvoltammetrymeasurements.TheN-dopedcarbonclothexhibitsoutstandingelectrochemicalactivityandreversibilitytowardV(IV)/V(V)redoxcouple.TherateconstantofV(IV)/V(V)redoxreactiononcarbonclothcanincreaseto2.27×10-4cm/sfrom1.47×10-4cm/safternitrogendoping.ThecellusingN-dopedcarbonclothaspositiveelectrodehaslargerdischargecapacityandhigherenergyefficiencycomparedwiththecellusingpristinecarboncloth.TheaverageenergyefficiencyofthecellusingN-dopedcarbonclothfor50cyclesat30mA/cm2is87.8%,4.3%largerthanthatofthecellusingpristinecarboncloth.ItindicatesthattheN-dopedcarbonclothhasapromiseapplicationprospectinvanadiumredoxflowbatteries.
简介:在这份报纸,在证明二存在的作者目的形式$$\left的部分微分边界价值问题结果({{P_{一,b}}}\right)\left\{{_{u\left(0\right)=u\left(1\right)=0,{D^{\alpha-3}}u\left(0\right)=一,u'\left(1\right)=-b}^{{D^\alpha}u\left(x\right)+f\left({x,u\left(x\right)}\right)=0,x\in\left({0,1}\right)}}\right.$$3<4,D是标准Riemann-Liouville部分衍生物并且一,b是nonnegative常数。首先,作者建议那f(x,t)=p(x)t,与(1,1)并且是的pnonnegative可能在x=单个的连续功能0或x=1并且满足与Karamata常规变化理论有关的一些条件。一些潜在的功能和Sch上的联合锋利的估计?uder修理了点定理,作者证明问题的一个唯一的积极连续答案的存在(P0,0)。如此的一个答案上的全球估计也被获得。为了说第二存在,结果,作者假定那一,b是nonnegative常数以便+b>0并且f(x,t)=t(x,t),与(x,t)nonnegative是连续的工作在(0,吗1)牵慦散猠摥浩湥獴映潲?慈桩?楒敶?慂楳?敷敲椠癮獥楴慧整??洠瑥潨?慢敳?湯攠晦'太B爠湡敧?剅?慷?獵摥琠?獡敳獳攠潣祳瑳浥爠獩?景倠??琨敨琠瑯污漠??倠??敳獮瑩癩汥?湡?捡畣慲顰?顰??
简介:Inthispaper,weareconcernedwiththesymmetricpositivesolutionsofa2n-orderboundaryvalueproblemsontimescales.Byusinginductionprinciple,thesymmetricformoftheGreen’sfunctionisestablished.Inordertoconstructanecessaryandsufficientconditionfortheexistenceresult,themethodofiterativetechniquewillbeused.Asanapplication,anexampleisgiventoillustrateourmainresult.
简介:Steptoean积极的碳同位素旅行(香料)的全球出现在期间晚寒武纪在海洋的碳周期记录了重要不安,并且可能在生物进化上有深刻影响。在以前的研究,香料在华南从Jiangnan斜坡带被报导了。评估香料的深测术的程度,我们在Jiangnan盆在Shaijiang节从上面的Qingxi形成调查石灰石样品。我们的结果为两碳酸盐碳显示出积极旅行(13C)并且器官的碳(13Corg)同位素,以及在碳酸盐的硫同位素的并发的积极移动联系了硫酸盐(CAS,34SCAS)和黄铁矿(34S不含糊地在Jiangnan盆显示香料的存在的黄铁矿),。13CQingxi石灰石的carb由二的一个因素暗示器官的碳埋葬的相对流动的增加。在34SCAS和34S黄铁矿与极其低的集中并且空间地在海洋被归因于提高的黄铁矿埋葬海水硫酸盐的异构的同位素的作文。这里,我们建议海水硫同位素的异质能被不稳定的器官的硫化合物产生(VOSC,例如methanethiol和dimethyl硫化物)在在香料期间是普遍的sulfidic大陆人边缘的形成。32在空气的充实S的VOSC,在32从大陆人边缘的S到开的海洋,提高34在大陆人边缘的海水硫酸盐的S。一个简单盒子模型显示在大陆人边缘的大约35%~75%海水硫酸盐需要被搬运经由VOSC形成打开海洋。
简介:BackgroundSepticshockcausedbybacteremiaisalife-threateninginfectionwhoseprognosisishighlydependentonearlyrecognitionandappropriatetreatment.Procalcitonin(PCT)hasbeenshowntoaccuratelyandquicklydistinguishbacteremiafromnoninfectiousinflammatorystatesincriticallyseverepatients.However,theextentofPCTmagnitudeelevationaccordingtotheGramstainresultinelderlypatientswithcoronaryheartdisease(CHD)attheonsetofsepticshockcausedbybacteremiavaries,andhasnotbeenclearlyelucidated.MethodsThemedicalrecordsofadvancedage(non-neutropenic)patientwithCHDandsepticshockbetweenMar2013andJun2015whohadbacteremiacausedbyeitherGram-positive(GP)bacteriaorGram-negative(GN)bacteriawerereviewed,andthelevelsofPCT,C-reactive(CRP)proteinandwhitebloodcellscount(WBC)inbothgroupswereanalyzed.Results75episodesofeitherGNbacteremia(n=40)orGPbacteremia(n=35)wereenrolled.PCTlevelswerefoundtobemarkedlyhigherinpatientswithGNbacteremiathaninthosewithGPbacteremia[(8.93±17.58)vs.(64.42±58.56)ng/L(P<0.001)],whereastherewasnosignificantdifferenceinCRPandWBC(P>0.05).Moreover,ahighPCTlevelwasfoundtobeindependentlyassociatedwithGNbacteremiainthisstudypopulation.APCTlevelof19.69ng/mLyieldeda72.5%sensitivity,a91.4%specificity,an8.43positivelikelihoodratioanda0.30negativelikelihoodratioforGN-relatedbacteremiainthestudycohort[AUROCC=0.870(0.041),95%CI(0.790-0.949)].ConclusionInanelderlypatient(non-neutropenic)withCHDandsepticshock,GNbacteremiacouldbeassociatedwithhigherPCTvaluesthanthosefoundinGPbacteremia(PCT>19.69ng/mL).
简介:我们与高风险的前列腺癌症在271个病人报导全面的率,地点和积极外科的边缘(PSM)的预兆的因素。在2008年4月和2011年10月之间,我们有希望地从作为D'Amico分类的病人收集了数据高风险经历了帮助机器人的laparoscopic激进分子前列腺切除术。PSM的全面的率和地点被报导。逐步的逻辑回归模型被适合估计PSM的预兆的因素。PSM的全面的率是25.1%(271个病人中的68个)。这些PSM,(68中的26个)38.2%是posterolateral(PL),26.5%(68中的18个)multifocal,16.2%(68中的11个)在顶,14.7%(68中的10个)在膀胱颈,并且4.4%(3/68)在另外的地点。有病理学的阶段pT2的病人的PSM率是8.6%(140中的12个),26.6%(64中的17个)pT3a,53.3%(32/60)pT4的pT3b,和100%(7中的7个)。在包括pre-,intra-,和手术后的参数的一个逻辑回归模型,身体团索引(机会比率[或]:1.09;95%信心间隔[CI]:1.01-1.19,P=0.029),病理学的舞台(pT3b或更高对pT2;或:5.14;95%CI:1.92-13.78;P=0.001)并且肿瘤的百分比(或:46.71;95%CI:6.37-342.57;P<0.001)是为PSM的独立预兆的因素。在病人在的PSM的最普通的地点高风险是PL方面,它反映报导肿瘤攻击性。PSM的唯一的重要预兆的因素是病理学的结果,例如在标本和病理学的舞台的肿瘤的百分比。
简介:三次积极的碳同位素旅行在Tahe油气体地里从中间上面的奥陶纪被报导,北Tarim盆。把biostratigraphy,中间的Darriwilian同位素碳旅行(MDICE)和Guttenberg碳同位素旅行(GICE)基于conodont被整个岩石的碳同位素数据的帮助从二个井核心从Darriwilian识别到早Katian。在conodontPygodusanserinus地区以内的积极旅行在早Sandbian被开发,并且变化范围是不亚于MDICE。因为在概括的全球碳同位素曲线的这次旅行的范围是短的,以前的研究几乎没对它给予注意,并且在这份报纸把早Sandbian称为同位素碳旅行(ESICE)。而且,这些积极旅行直接没在北Tarim与海水平变化和MDICE和GICE有关被识别能全球性在南部的中国,北美洲,南美洲,和欧洲被相关到那。SaerganFm。在KalpinDawangou露头的中间上面的奥陶纪的来源岩石与MDICE的地质的时间一致,ESICE,和GICE有强壮的关系到LianglitagFm的来源岩石。在盆。丰富的器官的碳埋葬是在积极同位素碳旅行的开始的一个重要因素。沉积外形的积极的氧同位素旅行,conodont动物志周转,减少的conodont总数差异,和变化显示在Tarim盆的早中间的奥陶纪的paleoceanographic环境的戏剧的变化近来从Darriwillian,和明显的冰库气候的结束开始了奥陶纪发生在ESICE。
简介:Objective:Apreviousstudydemonstratedthatnon-anthracycline-containingdocetaxelpluscyclophosphamide(TC)regimenwasinferiortodocetaxel,anthracyclineandcyclophosphamide(TAC)inneoadjuvanttreatmentoftriple-negativebreastcancer(TNBC)andhumanepidermalgrowthfactorreceptor-2-(HER2)-positivebreastcancerinashort-termfollow-up.Herein,long-termfollow-upsurvivaloutcomeshavebeeninvestigated.Methods:TNBCorHER2-positivepatientswererandomizedtoreceive6cyclesofTCorTACneoadjuvanttreatment.Theprimaryendpointwaspathologicalcompleteremission(pCR).Secondaryendpointsincludedclinicalresponserate,event-freesurvival(EFS),andoverallsurvival(OS).Results:Acohortof96patientsconsistedof45inTCand51inTACarm.Withamedianfollow-upperiodof53(range,8–76)months,thepatientsachievingpCRpostneoadjuvantchemotherapyexhibitedsuperiorEFSandOSthanpatientswithoutpCR(P<0.05).TACtreatmentresultedinconsistentlybetterEFSthanTCtreatment:theestimated5-yearEFSwas66.1%vs.29.8%(P=0.002).Moreover,theestimated5-yearOSwasalsoinfavorofTAC:88.4%vs.51.6%(P<0.001).Multivariableanalysisdemonstratedthatthetreatmentregimenwasanindependentprognosticfactor,andpatientstreatedwithTAChadasuperiorEFS[hazardratio(HR),0.48;95%confidenceinterval(95%CI),0.26–0.90;P=0.021]andOS(HR,0.20;95%CI,0.08–0.60;P=0.003).Conclusions:Theupdatedlong-termfollow-updatademonstratedasustainedbenefitinEFSandOSfromanthracycline-containingTACtreatment,indicatingthatanthracyclineisanessentialandeffectivedruginthisclinicaltrial.