简介：Osteoporosisisametabolicskeletaldisorderleadingtobonefracturewhichadverselyimpactsthequalityoflife.Inthepresent,weaimedtoinvestigatetheeffectofPeperomiapellucida(L.)Kunthherbjuiceandethanolicextractonovariectomy(OVX)-inducedosteoporoticratmodel.OsteoporosiswasinducedbyOVXwithadoubledorsolateralapproachonfemaleWistarrats.FemaleWistarratsundergoingshamsurgeries(sham-controlgroup)servedascontrols.Theovariectomizedratsweredividedintosixgroupsbasedonadministeredtreatments,(i)CMCNa0.3%(OVX-controlgroup),(ii)standarddrug(ethynilestradiol4.5μg/kg),(iii)P.pellucidajuiceatdoseof50mg/kg,and(iv)100mg/kg,(v)P.pellucidaethanolicextractatdoseof50mg/kg,and(vi)100mg/kg.Treatmentswerestarted1weekafterthesurgeriesandlastedfor6weeks.Ratstreatedwith100mg/kgP.pellucidaethanolextracthadsignificantlydecreasedserumALPlevelandreducedexcretionofurinecalciumcomparedwiththeOVX-controlgroup(P<0.05).Theselevelswerenotsignificantlyalteredwhencomparedwiththesham-controlgroup(P<0.05).Furthermore,100mg/kgethanolicextract-treatedgroupshowedimprovementonthree-dimensionalimageofthetrabecularbonecomparedwiththeOVX-controlgroup.Trabecularcavityformationin100mg/kgethanolicextract-treatedgroupwasminimal.EthanolicextractofPeperomiapellucida(L.)Kunthherbsatadoseof100mg/kghadpreventiveeffectonOVX-inducedosteoporoticrats.