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简介：AbstractBreast neuroendocrine carcinoma is a rare entity. It constitutes less than 0.5% of breast malignancies, and is usually diagnosed in older women. The occurrence of this type in young patients during pregnancy is extremely rare. Only 2 cases were previously reported. Both were diagnosed at earlier stage with the appearance of a palpable breast mass. Hereby, we present the case of a young patient at 28 weeks’ gestation admitted for severe diffuse back pain and neurologic deficit due to spinal cord compression at the level of C5 vertebra, and nerve root compression at the level of L5 vertebrae. To the best of our knowledge, this is the first case of oncologic emergency during pregnancy due to a metastatic poorly differentiated breast carcinoma with neuroendocrine differentiation in the absence of a detectable primary focus of malignancy in the breast. We also discuss the management and the obstetrical outcome of this patient.

简介：由于市场的快速的变化和比赛的压力，生产公司被强迫改编他们的生产方法支持顾客需要的差异和新产品开发的增加。因为生物有机体相当能够适应环境变化和刺激，启发简历的概念被认出了对适应生产合适系统控制。因此，这份报纸建议启发NeuroEndocrine的生产系统(NEIMS)的一个新奇概念。建议NEIMS控制体系结构与neuro控制和荷尔蒙规定原则基于类比。它有能力明确地包括控制点，材料，信息流动路径和逻辑操作指定生产控制计划，并且活泼地在商店地板水平处理意外骚乱的经常的出现。从控制论观点，NEIMS的控制模型由于外部环境在产品要求显示适应行为到变化并且作为内部环境生产房间失灵。最后，一个原型系统被设置了启用NEIMS模拟。

简介：AbstractPancreatic neuroendocrine tumors (pNET) are heterogenous tumors originated from the diffuse neuroendocrine cells of pancreas, which show the function of synthesis, storage and secretion of peptide hormones and biomimetic amines. Biomarkers play a crucial role in the diagnosing, evaluating prognosis and predicting treatment response for pNET patients. Traditional NET markers such as chromogranin A and Neuron Specific Enolase, as a diagnostic biomarker, have relatively low sensitivity and specificity in pNET patients. The emergence of new types of biomarkers provides more reliable indicators for diagnosis and prognosis evaluation. Among them, NETest score is a promising biomarker with the highest diagnostic sensitivity (80%) and specificity (94%). In addition, this molecule can be also used as a prognostic biomarker, which can predict disease progression and shorter overall survival. Biomarkers related to therapeutic targets, such as vascular endothelial growth factor, vascular endothelial growth factor receptor, and key molecules of mTOR signaling pathway, have capability to predict response of treatment. With the development of next-generation sequencing, chip array, and digital droplet PCR, novel biomarkers such as circulating tumor cells, tumor-derived exosomes, and circulating tumor DNA and mRNA are expected to provide more accurate diagnosis, prognostic information, and prospective therapeutic targets. In this paper, biomarkers of pancreatic neuroendocrine tumor and their role in diagnosis, prognosis, diagnosis, treatment and monitoring are systematically introduced. Our conclusions can provide new basis for clinicians in the diagnosis and treatment process.

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简介：AbstractPancreatic neuroendocrine neoplasms (pNENs) are highly heterogeneous, and the management of pNENs patients can be intractable. To address this challenge, an expert committee was established on behalf of the Chinese Pancreatic Surgery Association, which consisted of surgical oncologists, gastroenterologists, medical oncologists, endocrinologists, radiologists, pathologists, and nuclear medicine specialists. By reviewing the important issues regarding the diagnosis and treatment of pNENs, the committee concluded evidence-based statements and recommendations in this article, in order to further improve the management of pNENs patients in China.

简介：Gradingprocedureinroutineseacucumberhatcheryproductionisthoughttoaffectjuvenileseacucumberimmunologicalresponse.Thepresentstudyinvestigatedtheimpactofa3-minmechanicalperturbationmimickingthegradingprocedureonneuroendocrineandimmuneparametersoftheseacucumberApostichopusjaponicus.Duringtheapplicationofstress,concentrationsofnoradrenalineanddopamineincoelomicfluidincreasedsignificantly,indicatingthatthemechanicalperturbationresultedinatransientstateofstressinseacucumbers.Coelomocytesconcentrationincoelomicfluidincreasedtransientlyafterthebeginningofstressing,andreachedthemaximumin1h.Whereas,coelomocytesphagocytosisat3min,superoxideanionproductionfrom3minto0.5h,acidphosphataseactivityat0.5h,andphenoloxidaseactivityfrom3minto0.5hwereallsignificantlydown-regulated.Alloftheimmuneparametersrecoveredtobaselinelevelsaftertheexperimentwasconductedfor8h,andanimmunostimulationoccurredafterthestressconsideringthephagocytosisandacidphosphataseactivity.Theresultssuggestedthat,asinothermarineinvertebrates,neuroendocrine/immuneconnectionsexistinseacucumberA.japonicus.Mechanicalstresscanelicitaprofoundinfluenceonseacucumberneuroendocrinesystem.Neuroendocrinemessengersactinturntomodulatetheimmunityfunctions.Therefore,theseeffectsshouldbeconsideredfordevelopingbetterhusbandryprocedures.

简介：Neuroendocrinetumors(NET)areaheterogeneousgroupofcancers,withindolentbehavior.Themostcommonprimaryoriginisthegastro-intestinaltractbutcanalsoappearinthelungs,kidneys,adrenals,ovariesandotherorgans.Ingeneral,NETisusuallydiscoveredinthemetastaticphase(40%-80%).Theliveristhemostcommonorganinvolvedwhenmetastasesoccur(40%-93%),followedbybone(12%-20%)andlung(8%-10%).Anumberofdifferenttherapeuticoptionsareavailableforthetreatmentofhepaticmetastasesincludingsurgicalresection,transplantation,ablation,trans-arterialchemoembolization,chemotherapyandsomatostatinanalogues.Recently,moleculartargetedtherapieshavebeenused,usuallyincombinationwithothertreatmentoptions,toimproveoutcomesinpatientswithmetastases.ThisarticleemphasizesontheroleofsurgeryinthetreatmentoflivermetastasesfromNET.

简介：A64-year-oldmanwasadmittedtotheSunYat-SenUniversityCancerCenterwithchiefcomplaintsofrecurrentabdominalpainanddiarrheaforabout3yearsandwithahistoryofsurgicalrepairforintestinalperforationowingtostressulcer.Positronemissiontomography(PET)/computedtomography(CT)demonstratedaprimarytumoronthepancreatictailwithmultifocallivermetastases.Pathologicalandimmunohistochemistrystainingrevealedthelesiontobeapancreaticneuroendocrinetumor(pNET).AccordingtothelatestWorldHealthOrganization(WHO,2013)classification,thetumorwasclassifiedasstageIVfunctionalG1pNET.Afterreferraltothemultidisciplinarytreatmentboard(MDT),thepatientwasstartedonperiodicdoseofomeprazole,somatostatinanaloguesandInterferonα(IFNα)andhadscanningfollow-ups.Basedupontheimagingresults,CT-guidedradioactiveiodine-125(125I)seedsimplantationtherapy,radiofrequencyablationtherapy(RFA)ormicrowaveablationtechniquewerechosenforthetreatmentoftheprimarytumor.Transarterialchemoembolization(TACE),RFAandmicrowaveablationtechniquesweredecideduponforlivermetastases.Thepatientshowedbeneficialresponsetothetreatmentwithclinicallymanageablelow-gradesideeffectsandattainedpartialremission(RECISTcriteria)withagoodqualityoflife.

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简介：Ampullaryadenomaisacommonindicationforendoscopicpapillectomy.Ampullaryneuroendocrinetumor(NET)isararediseaseforwhichcompletesurgicalresectionisthetreatmentofchoice.However,becauseofthemorbidityandmortalityassociatedwithsurgicalresection,endoscopicpapillectomyisincreasinglyusedinselectedcasesoflowgrade,withnometastasisandnoinvasionofthepancreaticorbileduct.Also,confirmedandcompleteendoscopicresectionofampullaryNETaccompaniedbyadenomahasnotbeenreportedtodate.WereporthereinararecaseofanampullaryNETaccompaniedwithadenoma,whichwassuccessfullyandcompletelyresectedviaendoscopicpapillectomy.Priortopapillectomy,thiscasewasdiagnosedasanampullaryadenoma.

简介：AbstractThere has been a rising trend in the incidence and prevalence of non-functioning pancreatic neuroendocrine tumors (NFPanNETs). While a significant number of the newly diagnosed NFPanNETs are asymptomatic, a majority of patients will present with liver metastasis (LM) at the time of diagnosis. Surgical resection remains the only curative treatment, especially for localized NFPanNETs. While a majority of small NFPanNETs are indolent, some are not. This heterogeneity in tumor biology presents the surgeon with the unique challenge of determining which patient will benefit from surgery, given the morbidity of pancreatic surgery. There has been a recent push for a more aggressive approach to the care of these patients, given the emergence of data supporting such measures. However, the risk of over or under treatment has generated immense debate amongst experts in the field. The heterogeneity of current practice guidelines and institutional practices around the world is a reflection of the disparate opinion on the management of NFPanNET. In this review, we set out to examine the evidence regarding some of the most controversial and challenging aspects of the surgical treatment of NFPanNET. We evaluate the following questions; should patients with small NFPanNETs ≤ 2 cm in size be resected; should patients with metastatic NFPanNETs undergo surgical debulking, and should there be resection of the primary tumor in the setting of non-resectable metastatic disease?Although there are currently no Level 1 data to answer these questions conclusively, we believe that the current literature supports a more aggressive approach to the management of NFPanNET.

简介：Cancerscreeningisasourceofmuchdebate.Attheinterfacebetweenpublichealth,specialistcare,economicsandpolicy,itcreatestensionsbetweenprofessionalgroups,politicians,themediaandthepublic.Ascreeningtestmaybecheap,butapplyingittoapopulation(withrigorousqualitycontrolandeffectiveprocessingofpatientswithabnormalresults)createsahugeworkloadandthereforecost.Screeningcanalsohavepsychologicaleffectsonindividualswithfalse-positiveresultswhorequireinvestigationbutareeventuallyfoundnottohavecancer.

简介：Somaticstemcells(SSCs),beingessentialinmaintaininghomeostasisofnormaltissue,replenishdyingcellsandregeneratedamagedtissuesfororganism.Ontheotherhand,withtheself-renewedability,SSCsareidealcellulartargetstobeacquiredinmultiplemutationstransformingSSCstocancerstemcells(CSCs)whichcausemalignanciesandevenrecurrenceaftercancertreatmentifCSCsfailtobeeradicated(1).OneyearafterDrs.JohnB.GurdonandShinyaYamanakasharedthe2012NobelPrizeinPhysiologyorMedicinefortheirdiscoverythatmaturecellscanbereprogrammedtobecome

简介：Cancertreatmentfailure,drugresistance,ormetastaticrecurrencearethoughttobecausedmainlybytheexistenceofaverysmallnumberofcancerstemcells(CSCs).Thecharacteristicsofthissubgroupofcellsincludeself-renewal,tumorigenesis,multipledifferentiationandhighinvasiveness,metastasis,anddrugresistancepotential.ManystudieshavedemonstratedthatCSCsplayimportantrolesintumorgrowth,spreadandmetastaticrelapseaftertreatment,andarecloselyrelatedtotheprognosisofpatients.Fromatherapeuticviewpoint,deepinsightsintotheCSCsbiology,developmentofspecifictherapeuticstrategiesfortargetingCSCs,andcharacterizationoftheirmicroenvironmentcouldbeanidealwaytocombatcancer.

简介：Cancergenomicsisarapidlygrowingdisciplineinwhichthegeneticmolecularbasisofmalignancyisstudiedatthescaleofwholegenomes.Whilethedisciplinehasbeensuccessfulwithrespecttoidentifyingspecificoncogenesandtumorsuppressorsinvolvedinoncogenesis,itisalsochallengingourapproachtomanagingpatientssufferingfromthisdeadlydisease.Specificallycancergenomicsisdrivingclinicaloncologytotakeamoremolecularapproachtodiagnosis,prognostication,andtreatmentselection.Wereviewhererecentworkundertakenincancergenomicswithanemphasisontranslationofgenomicfindings.Finally,wediscussscientificchallengesandresearchopportunitiesemergingfromfindingsderivedthroughanalysisoftumorswithhigh-depthsequencing.

简介：Ithabeenknownforsometimethatsometumourshavetheabilitytoproducaehormones.Thishastraditionallybeentermed‘ectopic'hormoneproduction,butwiththeincreasingsensitivityofmodenmoleculartechniques,ithasbecomeclearthatthisisamisnomer;manytissuescanproducehormoner,andnormallydosoatlowlevels,thehormonesactinglocallyascytokinesinaparacrinemanner.Intumours,bymechanismsthatremainunclear,productionofthesehormonesand/orincompletelyprocessedprecursorsisinereased,andthetem‘eutopic’productionismoreappropriate.

简介：尽管氧化是最普通生物并且精力生产反应，因为象自由激进分子和过氧化物那样的氧化的产品损坏细胞的部件，氧化应力对房间有害，引起几疾病。在DNA的损坏为癌症形成和前进负责。然而，几酶象superoxidedismutase那样，过氧化氢酶，谷胱甘肽peroxidase，谷胱甘肽reductase，是的谷胱甘肽S-transferase等等行为影响氧化应力的抗氧化剂。在这些酶的多型性应当与DNA损坏被联系，随后，个人癌症冒险危险性。这篇评论文章试图进一步阐明在由在癌症病人有关表示层次和抗氧化剂酶的基因多型性总结一些重要学习的调查结果的抗氧化剂酶和癌症之间的关系。

简介：Cancerhasbecometheleadingcauseofdeath.Theprogressindiagnosisandtreatmentisstilllimited.Overthepastthreedecades,emergenceandrapiddevelopmentofnanotechnologyhavebroughtnewhopesforcancertherapy.Arepertoireofnanomaterialswithcontrollablesize-,shape-,andcomposition-dependentphysiochemicalproperties

简介：Inthepastdecade,anincreasedamountofclinically-orientedresearchinvolvingimmunotoxinshasbeenpublished.Immunotoxinsareagroupofartificially-madecytotoxicmoleculestargetingcancercells.Thesemoleculescomposedofatargetingmoiety,suchasaligandoranantibody,linkedtotoxinmoiety,whichisatoxinwitheithertruncatedordeletedcell-bindingdomainthatpreventsitfrombindingtonormalcells.Immunotoxinscanbedividedintotwocategories:chemicallyconjugatedimmunotoxinsandrecombinantones.Theimmunotoxinsofthefirstcategoryhaveshownlimitedefficacyinclinicaltrialsinpatientswithhematologicmalignanciesandsolidtumors.Withinthelastfewyears,single-chainimmunotoxinsprovideenhancedtherapeuticefficacyoverconjugatedformsandresultinimprovedantitumoractivity.Inthisreview,webrieflyillustratethedesignoftheimmunotoxinsandtheirapplicationsinclinicaltrials.Cellular&MolecularImmunology.2005;2(2):106-112.