简介:<正>YouranisthenameLeonagavetoherson,indicatingherlongingforapeacefulandpleasantlifesheandBradBeisherhasbeenpursuing.However,thecoupleisverybusywiththeirownbusinessesandonlygathersinlatenighteachworkingday.Evenovertheweekend,theircellphonesringoftenasBradBeisherisrunningarealestateagentfirmofhisownandZongisworkinginatradingcompanyofhand-blownglassware.
简介:Theoreticalandexperimentalresearchoflowfrequencypulsecompressionandchannelmatchinshallowwatersoundchannelwerecarriedoutbasedon2000-WinterYellowSeaexperiment.Usingpulsecompressionmethod,signalswithhighsignaltonoiseratio(SNR)werereceivedoverrangeof110kilometersintheexperiment.TheSNRgainintheprocessisconsistentwiththetheoreticalprediction.Theexperimentalmeasurementindicatedthatthechannelishighlycoherentoveralengthof500s.ChannelmatchmethodwasusedtocompensatethedegradationofpulsecompressionSNRcausedbythemulti-pathpropagation.AndtheSNRgaininthechannelmatchprocesscanbetheoreticallypredicted.ExperimentalresultsshowthatlowfrequencypulsecompressionandchannelmatchmethodcanbeusedinshallowwatersoundchanneltoimprovetheSNR.
简介:AIM:Toinvestigatethediversecharacteristicsofdifferentpathologicalgradingsofgastricadenocarcinoma(GA)usingtumor-relatedgenes.METHODS:GAtissuesindifferentpathologicalgradingsandnormaltissuesweresubjectedtotissuearrays.Expressionsof15majortumor-relatedgenesweredetectedbyRNAinsituhybridizationalongwith3’terminaldigoxin-labeledanti-sensesinglestrandedoligonucleotideandlockednucleicacidmodifyingprobewithinthetissuearray.Thedataobtainedwereprocessedbysupportvectormachinesbyfourdifferentfeatureselectionmethodstodiscovertherespectivecriticalgene/genesubsetscontributingtotheGAactivitiesofdifferentpathologicalgradings.RESULTS:IncomparisonofpoorlydifferentiatedGAwithnormaltissues,tumor-relatedgeneTP53playsakeyrole,althoughothersixtumor-relatedgenescouldalsoachievetheAreaUnderCurve(AUC)ofthereceiveroperatingcharacteristicindependentlybymorethan80%.ComparingthewelldifferentiatedGAwithnormaltissues,wefoundthat11tumor-relatedgenescouldindependentlyobtaintheAUCbymorethan80%,butonlythegenesubsets,TP53,RBandPTEN,playakeyrole.Onlythegenesubsets,Bcl10,UVRAG,APC,Beclin1,NM23,PTENandRBcoulddistinguishbetweenthepoorlydifferentiatedandwelldifferentiatedGA.Noneofasinglegenecouldobtainavaliddistinction.CONCLUSION:Differentfromthetraditionalpointofview,thewelldifferentiatedcancertissueshavemorealterationsofimportanttumor-relatedgenesthanthepoorlydifferentiatedcancertissues.
简介:Inthispaper,anewmethod,namedasL-treematch,ispresentedforextractingdatafromcomplexdatasources.Firstly,basedondataextractionlogicpresentedinthiswork,anewdataextractionmodelisconstructedinwhichmodelcomponentsarestructurallycorrelatedviaageneralizedtemplate.Secondly,adatabase-populatingmechanismisbuilt,alongwithsomeobject-manipulatingoperationsneededforflexibledatabasedesign,tosupportdataextractionfromhugetextstream.Thirdly,top-downandbottom-upstrategiesarecombinedtodesignanewextractionalgorithmthatcanextractdatafromdatasourceswithoptional,unordered,nested,and/ornoisycomponents.Lastly,thismethodisappliedtoextractaccuratedatafrombiologicaldocumentsamountingto100GBforthefirstonlineintegratedbiologicaldatawarehouseofChina.