简介：DearEditor,Wewouldliketopresenttheimportanceofmultimodalimaginginphoticretinopathyinacaseofphoticretinopathy.Ayoungmanpresentedwithaone-dayhistoryofleftcentralscotomaandmetamorphopsiaafterexposuretoahandheldlaserpointerbeamduringanightparty.ThelaserpointerwasaclassIIIBgreenlaserwithawavelengthof532±10nmandmaximalpower<1000mW.However.

简介：

简介：信息熔化是在多模式的生物测定的系统的关键步。特征级的熔化是比由于原来的特征集合关于生物测定的数据包含更富有的信息的事实的分数级、决定级的方法更有效的。在这份报纸，我们在场当时，为特征级的多模式的生物测定的信息熔化的概括正规判别式设计(MGCDP)方法，它最大化intra班的关联展示的multiset最小化在班之间的关联。另外，连续MGCDP(S-MGCDP)和策略也是的平行MGCDP(P-MGCDP)求婚了，它能多于二种生物测定的信息熔化，以便完成更好的鉴定效果。实验在MGCDP方法超过的各种各样的生物测定的数据库表演表现了另外的最先进的特征级的信息熔化途径。

简介：

简介：

简介：

简介：

简介：AbstractBackground:The combination of high-frequency oscillations (HFOs) with single-mode imaging methods has been proved useful in identifying epileptogenic zones, whereas few studies have examined HFOs combined with multimodal imaging methods. The aim of this study was to evaluate the prognostic value of ripples, an HFO subtype with a frequency of 80 to 200 Hz is combined with multimodal imaging methods in predicting epilepsy surgery outcome.Methods:HFOs were analyzed in 21 consecutive medically refractory epilepsy patients who underwent epilepsy surgery. All patients underwent positron emission tomography (PET) and deep electrode implantation for stereo-electroencephalography (SEEG); 11 patients underwent magnetoencephalography (MEG). Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in predicting surgical outcome were calculated for ripples combined with PET, MEG, both PET and MEG, and PET combined with MEG. Kaplan-Meier survival analyses were conducted in each group to estimate prognostic value.Results:The study included 13 men and 8 women. Accuracy for ripples, PET, and MEG alone in predicting surgical outcome was 42.9%, 42.9%, and 81.8%, respectively. Accuracy for ripples combined with PET and MEG was the highest. Resection of regions identified by ripples, MEG dipoles, and combined PET findings was significantly associated with better surgical outcome (P < 0.05).Conclusions:Intracranial electrodes are essential to detect regions which generate ripples and to remove these areas which indicate good surgical outcome for medically intractable epilepsy. With the assistance of presurgical noninvasive imaging examinations, PET and MEG, for example, the SEEG electrodes would identify epileptogenic regions more effectively.

简介：

简介：AbstractBackground:Angiogenesis and hypoxia-inducible factor 1α (HIF-1α) play major roles in solid tumors. This study aimed to establish a longitudinal and multimodal imaging model for in vivo evaluation of HIF1α and angiogenesis in breast cancer.Methods:By transfection of a 5 hypoxia-responsive element (HRE)/green fluorescent protein (GFP) plasmid, the cell line Ca761-hregfp was established, which emitted green fluorescence triggered by HIF-1α under hypoxia. The cells were subjected to CoCl2-simulated hypoxia to confirm the imaging strategy. We grew Ca761-hre-gfp cells in the left rear flanks of twelve 615 mice. Experiments were conducted on days 4, 9, 15, and 19. For in vivo analysis, Ca761-hre-gfp subcutaneous allografted tumors were imaged in vivo using contrast-enhanced ultrasound (CEUS) and fluorescence imaging (FLI) during tumor development. The tumor size, CEUS peak intensity, and FLI photons were measured to evaluate tumor growth, angiogenesis, and HIF-1α activity, respectively. After each experiment, three mice were randomly sacrificed and tumor specimens were collected to examine HIF-1α activity and the microvessel density (MVD).Results:In vitro, both green fluorescence and HIF-1α expression were detected in Ca761-hre-gfp cells treated with CoCl2, indicating the suitability of the cells to detect HIF-1α activity. In vivo, HIF-1α activity first increased and then decreased, which was significantly correlated with angiogenic changes (r = 0.803, P = 0.005). These changes were confirmed by immunohistochemical staining of HIF-1α and MVD.Conclusions:The findings validated the Ca761-hre-gfp murine allograft model for reliable evaluation of HIF-1α activity and angiogenesis longitudinally using both molecular and pre-clinical non-invasive imaging modalities. The cell line may be useful for studies of anti-HIF pathway therapies.

简介：

简介：Wedemonstrateapassivelymode-lockedall-fiberlaserincorporatingapieceofgraded-indexmultimodefiberasamode-lockingmodulatorbasedonanonlinearmultimodalinterferencetechnique,whichgeneratestwotypesofcoexistinghigh-energyultrashortpulses(i.e.,theconventionalsoliton(CS)andthestretchedpulse(SP))TheCSwithpulseenergyashighas0.38nJisobtainedatthepumplevelof130mW.Whenthepumpincreasesto175mW,thehigh-energySPoccursatasuitablenonlinearphasebiasanditspulseenergycanreach4nJata610mWpump.ThepulsedurationsofthegeneratedCSandSPare2.3psand387fs,respectively.Thetheoryofnonlinearfiberoptics,single-shotspectralmeasurementbythedispersiveFourier-transformtechnique,andsimulationmethodsbasedontheGinzburg–LandauequationareprovidedtocharacterizethelaserphysicsandrevealtheunderlyingprinciplesofthegeneratedCSandSP.Aroguewave,observedbetweentheCSandSPregions,mirrorsthelaserphysicsbehindthedynamicsofgeneratingahigh-energySPfromaCS.Theproposedall-fiberlaserisversatile,cost-effectiveandeasytointegrate,whichprovidesapromisingsolutionforhigh-energypulsegeneration.