简介:Wehavepreviouslydemonstratedtheabilityofmalariaparasitestointerferewithspecificimmuneresponses.CD4Tcellsspecifictoparasiteantigens,butnotCD4Tcellsspecifictoanirrelevantantigen,ovalbumin(OVA),aredeletedviaapoptosisduringmalariainfection.Itisofinterest,therefore,toinvestigatetheimmuneresponsesthatdevelopedfollowingvaccinationwiththe19kDacarboxylterminusofthemerozoitesurfaceprotein1(MSP119)inmicethathadpreviouslyexperiencedmalariainfection.Inthisstudy,pre-exposureofmicetoPlasmodiumyoeliielicitednativeanti-MSP119antibodyresponses,whichcouldbeboostedbyvaccinationwithrecombinantMSP119,Likewise,infectionofMSP119-primedmicewithPlasmodiumyoelii(P.yoelii)ledtoanincreaseofanti-MSP119antibodies.MSP119vaccinationofmalariapreexposedmiceorimmunizationbyinfection/cureofMSP119-primedmiceenabledthemicetosurvivechallengeinfection,withtheformergrouphavingslightlylowerparasitaemia.Thedatasuggestthatexposuretomalariainfectionprimesanaturalimmuneresponsewhichcanbeboostedbyvaccination.Thisinformationisrelevanttothedevelopmentofavaccineforuseinindividualslivinginmalaria-endemicareas.
简介:Thebaryonspectrumandthebaryoncouplingsaretwoofthemostimportantissuesinhadronicphysicsandtheyareattractingmuchattention.Bothontheexperimentalandtheoreticalsides,thenucleonexcitedstatesbelow2.0GeVhavebeenextensivelystudied[1].However,thecurrentinformationforthepropertiesofstatesaroundorabove2.0GeVisscarce.Ontheotherhand,inthisenergyregion,manytheoreticalapproacheshavepredictedmissingNstates,whichhavenotbeensofarobserved.Hence,thestudyofthepossibleroleplayedbythe2.0GeVregionnucleonresonancesintheavailableaccuratedataistimelyandcouldshedlightintothecomplicateddynamicsthatgovernsthehighexcitednucleonspectrum.