简介:摘要目的探讨III型前胶原、血清透明质酸和层粘连蛋白在糖尿病肾病中的临床意义。方法11例糖尿病肾病病人,15例慢性肾炎病人采血测定血肌酐(SCr),血尿素氮(BUN)等生化指标以及III型前胶原(procollagentypeIII,PCIII)、血清透明质酸(hyaluronicacid,HA)、层粘连蛋白(LN)等放免指标与正常组进行对比。结果与正常对照组比较※P<0.01,糖尿病肾病组与正常对照组HA、LN、PCIII比较有显著性差异(P<001)。慢性肾炎与正常组比较无显著差异(P>0.05)。结论HA、LN、PCIII在对糖尿病肾病的进程中有一定的作用,并针对情况进行有效防治对预防终末期肾病有着十分重要的意义。
简介:Thesorptionbehaviorandmechanismofanovelchelateresin,diglycolamidicacidresin(DAAR),forSm(lll)wereinvestigated.TheoptimalsorptionconditionofDAARforSm(lll)ispH=6.0inHAc-NaAcmedium.Thestaticallysaturatedsorptioncapacityis190mg/gresinat298K.TheSm(lll)adsorbedonDAARcanbeelutedreaching100%by0.5-2.0mol/LHCIusedaseluant.Theresincanberegeneratedandreusedwithoutapparentdecreaseofsorptioncapacity.Theapparentsorptionrateconstantisk298=1.96×10^-5s^-1.Theapparentactivationenergyis26kJ/mol.ThesorptionbehaviorofDAARforSm(lll)obeystheFreundlichisotherm.Thethermodynamicsorptionparameters,enthalpychangeΔHofDAARforSm(lll)is16.9Kl/mol.ThemolarcoordinationratioofthefunctionalgroupofDAARtoSin(111)is3.ThesorptionmechanismofDAARforSm(lll)wasexaminedbyusingchemicalmethodandIRspectrometry.ThecoordinationbondwasformedbetweenoxygenatomsinthefunctionalgroupofDAARandSin(Ill).
简介:TheThirdWesternPacificRegionalAcousticsConference(WESTPACIII)washeldinNov.2-4,1988attheMagnollaHotelinShanghai.TheWESTPACIIIwasco-sponsoredbytheAcousticalSocietyofChina,theInstituteofAcousticsofAcademiaSinicaandtheAcousticalSocietyofShanghai.298scientistsandengineersfrom14countriesandareas,includingChina,Japan,Korea(South),India,HogngKong,NewZealand,Australia,Singapore,USA,GreatBritain,Denmark,Sweden,F.R.GermanyandIsrael,participatedintheWESTPACIII.TheopeningceremonywasheldinthemorningofNov.2.Prof.YingChongfu,Chairmanoftheorganizingcommitteemadetheopeningspeech.Intheplenaryses-sion,Prof.HiroyaFujisakifromUniv.ofTokyo,Japan,Prof.A.C.KibblewhitefromUniv.ofAuckland,NewZealandandProfWeiRongjuefromNanjingUniv.,
简介:ChinaandCanadahavesignedaprojectawardagreementfortheco-operationfortheQinshanPhaseⅢCandunuclearpowerproject,markingsignificantprogressincommercialnegotiationsbetweenbothcountriesontheconstructionoftwo700megawattclassCanduunits.Theagreement,signedbetweentheChinaNationalNuclearCorp(CNNC)andtheAtomicEnergyofCanadaLtd(AECL)inBeijingonJuly12,finalizedthepriceandcommercialtermsforQinshanPhaseⅢ
简介:Thesemightyfallsareoneofthegreatnaturalwondersoftheworldalthoughtheyarenot,infact,nearlythehighestintheworld-theKaieteurFalls,forinstance,inBritishGuianabeingfivetimesashigh.TheyarepartlyinCanadaandpartlyintheUnitedStates,astheboundarybetweenthetwocountriesfollowstheRiverNiagara.ThisflowsfromLakeErieintoLakeOntario,andinitscourse
简介:TheIGCCpowergenerationdemonstrationprojectinYantaiCity,ShandongProvinceistheState’scleancoalpowergenerationdemonstrationproject.Theconstructionscaleofthefirstphaseistobuildone300MWor400MWgeneratingunit,withreservedspaceforextension.Themainequipment,andmaind
简介:Fivenewchloranilato-bridgedbinuclearchromium(III)complexeshavebeensynthesizedandidentifiedas[Cr2(CA)L4]-(ClO4)4[Ldenotes5-methyl-1,10-phenanthroline(Me-phen);2,9-dimethyl-1,10-phenanthroline(Me2-phen);5-chloro-1,10-phenanthroline(Cl-phen);diaminoethane(en)or1,3-diaminopropane(pn)],whereCArepresentsthedianionofchloranilicacid.Basedonelementalanalyses,molarconductivityandmagneticmomentofroom-temperaturemeasurements,andIRandelectronicspectralstudies,itisproposedthatthesecomplexeshaveCA-bridgedstructuresandconsistoftwochromium(III)ions,eachinanoctahedralenvironment.Thecomplexes[Cr2(CA)(Me-phen)4](ClO4)4(1)and[Cr2(CA)(Me2-phen)4](ClO4)4(2)werefurthercharacterizedbyvariabletemperature(4.2-300K)magneticsusceptibilitymeasurementsandtheobserveddataweresuccessfullysimulatedbytheequationbasedonthespinHamiltonianoperator,,givingtheexchangeparameterJ=-7.8cm-1for(1)andJ=-6.5cm*1for(2).Thisresult
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简介:目的观察血管内皮生长因子(VEGF)抗体靶向血管治疗对人增生性瘢痕Ⅰ型胶原蛋白在裸鼠体内表达的影响。方法将1%TBSA深Ⅱ度创面愈合后的增生性瘢痕组织块(取自1例女性烧伤患者)植入48只BALA/C裸鼠肩胛部皮下,建立裸鼠增生性瘢痕移植模型。术后3周,将裸鼠分为大剂量组、中剂量组、小剂量组及对照组,每组12只,分别用0.01mol/L灭菌磷酸盐缓冲液(PBS)稀释的15、10、5μg/mlVEGF单克隆抗体200μl以及等量、同浓度的PBS进行瘢痕内直接注射,每周2次,持续3周。术后45d,测量各组裸鼠瘢痕组织的大小,计算体积;以HE染色行组织学观察;采用逆转录聚合酶链反应与蛋白质印迹法分析瘢痕组织Ⅰ型前胶原蛋白mRNA和Ⅰ型胶原蛋白的表达。结果大剂量组、中剂量组、小剂量组瘢痕体积分别为(55.3±4.1)、(67.9±5.7)、(78.9±5.5)mm^3;与对照组(85.0±7.3)mm^3比较,大剂量组、中剂量组瘢痕体积明显变小(P〈0.05)。大剂量组、中剂量组血管和成纤维细胞较少,胶原纤维减少,排列较整齐。与对照组比较,大剂量组和中剂量组Ⅰ型前胶原蛋白mRNA和Ⅰ型胶原蛋白表达明显降低;小剂量组与之接近。结论VEGF抗体靶向血管治疗可抑制增生性瘢痕血管形成、胶原表达及瘢痕生长。