简介:TelomeraseisanenzymethatmaintainstelomeresindividingcellsusingatemplateonitsinherentRNAcomponent.Additionally,theproteinpartTERT(TelomeraseReverseTranscriptase)hasvariousnon-canonicalfunctions.Forexample,itcanlocalizetomitochondriaunderincreasedstressandprotectcellsinvitrofromoxidativestress,DNAdamageandapoptosis.RecentlyithasbeendemonstratedthatTERTproteinpersistsinadultneuronsinthebrainanddataemergesuggestingthatitmighthaveaprotectivefunctioninthesepost-mitoticcellsaswell.WehaverecentlypublishedthatTERTproteinaccumulatedinmitochondriafrombraintissueofmicethathaveundergoneshort-termdietaryrestriction(DR)andrapamycintreatment.Thislocalizationcorrelatedtolowerlevelsofoxidativestressinthesebrainmitochondria.SincerapamycintreatmentdecreasesmTORsignalingwhichisalsothoughttoplayanimportantroleforthebeneficialeffectsofDR,weconcludethatthemTORpathwaymightbeinvolvedintheTERTlocalizationanditseffectsinbrainmitochondriainvivo.ThesedataareinlinewithpreviousfindingsfromourgroupaboutincreasedmitochondriallocalizationofTERTinAlzheimer'sdisease(AD)brainsandaprotectivefunctionofTERTproteininneuronsinvitroagainstpathologicaltau.
简介:Rareearthindustry,withproductionvaluelessthan30trillionyuan,hasbecomethehottopicbothinsideChinaandintherestoftheworldsince2009.Eveninstockmarket,rareearthwasoneofthemostactivesectors.Mediainvariouscountries,specialistsindifferentfieldsandmanypoliticalfiguresworldwideaswellassomenetizensshowedextraordinaryconcerns
简介:在这篇论文,我们与间隔参数为网络连接问题介绍一个得最高分的战略模型。我们考虑怎么在一项给定的预算下面与一条路径或一棵跨越的树在一个网络连接给定的节点,在每个连接与间隔被联系并且能在间隔以任何值的成本被建立的地方。一个单个连接的质量(或连接失败的风险,等等)取决于它的构造费用和联系间隔。完成网络连接的公平,我们在在所有连接上的最大的风险的最小化的模型目的使用了。我们建议分别地在多项式时间发现最佳的路径和跨越的树的二个算法。多项式解决之可能性与间隔数据为网络连接显示我们的得最高分的战略模型和柔韧的偏差标准的模型之间的突出的差别,它产生NP难的优化问题。
简介:Inthispaper,opticalcross-connection(OXC)inducedcrosstalkhasbeencarefullyanalyzedformultiwavelengthall-opticalnetworks.Formulaearederivedforcalculatingthecrosstalkpowerofhomowavelengthcrosstalkandthetotalcrosstalkatthereceiverend.TheresultsshowthattheopticalswitchesinducedcrosstalkdominatesoverothercrosstalkcomponentsofOXC,andtheaccumulatedhomowavelengthcrosstalkincreasesalmostlinearlywiththeincreasingoftheOXCnumber.Atthereceiverend,theheterowavelengthcrosstalkinducedbythereceiveropticalfilterhasthesameorderasthatofhomowavelengthcrosstalkofOXC.Theresultsofdifferentopticalcomponentsmodelarealsodiscussed.
简介:Thispaperaimstoinvestigatethehydrodynamicbehaviorofatensionlegplatform(TLP)whenthetendonconnectionanglesarevariedat90°,70°,50°,and30°.ThreedifferenttypesofloadingconditionsareappliedtotheTLP.Conditionsinclude100-yearhurricanestormperiod,regularwavesandnoloading.TheTLPdisplayedmajorresponseinthepitchdegreeoffreedom.Amaximumreductionof14%inpitchrotationisachievedwhen100-yearhurricanestormconditionsareappliedtotheTLP.Thisoccurredin0°loadingsat30°tendonconnectionangleascomparedto90°tendonconnectionangle.Reductioninpitchrotationisalsoachievedintheregularwaveloadings.Amaximumof9%inpitchrotationisachievedduring0°waveloadingat30°tendonconnectionangleascomparedto90°.Whenthetendonconnectionangleisreducedfrom90°to30°,thenaturalfrequencyoftheTLPincreasedbothinpitchandyawdegreesoffreedomby2.55%and2.40%,respectively.
简介:Inthereportof19thNationalCongressoftheCommunistPartyofChina,GeneralSecretaryXiJinpingsaidthatChinaseeksto'acceleratedevelopmentofthecrimepreventionandcontrolsystem,combatandpunishinaccordancewithlawallillegalandcriminalactivitiessuchaspornography,gambling,drugabuse,gangviolence,kidnapping,andfraud,andprotectpeople’spersonalrights,propertyrights,andright
简介:Multicastcapability,includingmulticastaddressandmulticastroutingmechanisms,atthenetworklayerisnecessaryinordertoreducethebandwidthrequirementsofmultiparty,multicastapplications.Basedonhierarchicalautonomousstructureinaccordancewiththeself-organizationtopologiesofInternet,thepaperputsforwardamulticastaddressmanagementschemethatisshowntoberobustandscalable.Connectioncontrolhierarchy(CCH)basedonmaster/slaverelationshipandasimpleefficientbuildingalgorithmofmulti-pointconnectionisalsobuilt.Thepaperalsodescribesthenormaloperationsofmulticastaddressmanagementandmulti-pointconnectioncontroller.Throughsimulationexperiment,HAMCMandDDMofMulticastAddressAllocationarecompared.HAMintegratesthemeritsofCMandDDM,whichisefficientasawhole,robustandscalable.CCHraisestheefficiencyofconnectioncontrol,andishighlyrobust,flexibleandscalable.
简介:Nanowireshavebeenprovedtobeexcellentcandidatesforfuturenanodevicesfortheiradvantagesofbeingthesmallestchargecarrier,enablingabundantchoiceofmaterials,andrelatedsize,surfaceandquantumeffects.Nanowiresthusplayimportantroletounderstandthephysicalphenomenabetweenmacro-scaleNewtonworldandthemicro-scalequantummechanicalworld.Ourgroupisamongthefewpioneersinearly1998'sindevelopingmethodsforsynthesisofsiliconnanowires,andextendingthenanowiresynt...
简介:工业化大楼系统(IBS)最近被介绍最小化工程建设的时间和费用。因此,在IBS结构保证预制部件的连接的集成是保证从地震,车辆,和机械受到动态负担的大楼的稳定性的一个重要因素。然而,结构的工程师仍然在合适的连接上缺乏知识,IBS的详细关节组织建设。因此,这研究建议为抵抗multidirectional的动态负担的一个特殊预制具体铺满地板的连接系统强加了负担和还原剂颤动效果(PI2014701723)。这个系统被设计由使用二钢连接二块邻近的预制的墙面板U字形的隧道(即,男、女的关节)。在扔期间,每个关节在考虑下列条件以后为加入被改编进一块各自的墙面板:钢隧道的一个方面通向面板的厚度脸;U字形的橡胶在二条隧道之间被实现驱散颤动效果;并且螺栓和坚果被用来创造在二条U字形的男、女的钢隧道之间的延期。预制的墙的发达有限元素模型受到周期的负担在强加的动态负担期间评估建议连接的表演。连接性能当时基于在塑料范围的能量驱散,压力,变丑,和具体损坏与常规连接相比。建议预制连接能够超过受到动态负担的预制的墙的能量吸收,从而在所有主要方向改进它的抵抗行为。