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简介：AcupointShousanli(LI10)isalsocalledShangsanli,Guixie,locatesattheradialaspectofthebackoftheforearm,2cunbelowQuchi(LI11),onthelinejoiningYangxi(LI5)andQuchi(LI11).Shousanli(LI10)wasfirstlyrecordedinZhenJiuJiaYiJing(A-BCanonofAcupunctureand

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简介：AbstractAlthough whole-exome sequencing and whole-genome sequencing has tremendously improved our understanding of the genetic etiology of human disorders, about half of the patients still do not receive a molecular diagnosis. The high fraction of variants with uncertain significance and the challenges of interpretation of noncoding variants have urged scientists to implement RNA sequencing (RNA-seq) in the diagnostic approach as a high throughput assay to complement genomic data with functional evidence. RNA-seq data can be used to identify aberrantly spliced genes, detect allele-specific expression, and identify gene expression outliers. Amongst eight studies utilizing RNA-seq, a mean diagnostic uplift of 15% has been reported. Here, we provide an overview of how RNA-seq has been implemented to aid in identifying the causal variants of Mendelian disorders.

简介：根据古代文献资料，对足太阳膀胱经的穴位申脉的临床应用进行总结。临床上，申脉可以应用于治疗精神性疾病、失眠症、运动性疾病以及眼疾病等。

简介：Inthispaper,theauthorsintroducemedicinalvesiculationtherapyfromitsorigin,pointsforattentioninclinicalapplication,andtheirindividualexperiences.Inclinicalapplication,theauthorsadvocate:①avoidusingdrugsthatareover-irritatingintheproperty,andstrictlycontrollingthedoseofdrugsendthedurationofapplication,②)inselectionofdrugs,somefactorsaspatients'conditions,theseason,thegeographiclocation,etc.shouldbetakenintoaccount.Inthepresentpaper,3typicalcasesofbronchialasthma,tonsilswellingandfacialparalysistreatedwithmedicinalvesiculationtherapyareintroduced.Clinicalpracticedemonsetratesthatthistherapyiseconomical,simpleandconvenientandfairlyeffectiveintreatmentofsomechronicdiseases.

简介：Thespleen-stomachtheoryisaveryvaluablecompositionoftheTCM.ItisoriginatedfromNeijing（《内经》),initiatedinJin-Yuanperiodsandtheidea“spleenandstomachisthepostnatalbaseoflife”inPiweilun(《脾胃论》)writtenbyLIDong-yuanestablisheditstheoreticalbasis.Directedbythistheory,theauthorcuredseveralcases,anditisnowreportedbelow.

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简介：AbstractPlatelet-rich fibrin (PRF) is a second-generation platelet concentrate obtained from autologous blood. PRF is composed of abundant platelets, leucocytes, and a high concentration of various growth factors and fibrinogen. The composition and three-dimensional structure of PRF enable it to effectively make cells migrate and proliferate, playing an important role in tissue repair. Furthermore, the easy preparation and low cost of PRF make it a good treatment option. Numerous articles have been published about the application of PRF in clinical practice, however, the application of PRF in dermatology has not been comprehensively reviewed. The objective of this review article was to discuss various applications of PRF in dermatology, including healing chronic wounds, treating androgenic alopecia, skin rejuvenation, autologous fat transplantation, and treating vitiligo. PRF is a promising dermatologic treatment, but lacks a standardized protocol regarding its methods of attainment and use, which needs more investigations.

简介：Inthepresentpaper,combiningafewoftypicalcases,theauthorintroduceshisclinicalexperiencesabouttheapplicationofmultipleacupunctureneedlesinsertedintoacertainlocalregionfortreatmentoffacialspasm,Iumbago,hyperplasisofthemammayglandsandherpeszosterandgivessomebriefcomments.

简介：Objective:Toanalyzetheprinciplemechanismofthearcusplantarisanditsclinicalapplication.Methods:Thestatesofforcessustainedbythearcusplantariswereanalyzedandcalculatedaccordingtothemechanismofthequadraticparabolicarch.Results:Theaponeurosisplantariscorrespondedtothepullrodofthearcusplantaris.Themedialandlaterallongitudinalarchesformedbythepedalboneswerestablewiththerod,butunstablewithouttherod.Inthelattercondition,onloading,theforcesustaingedbytheparabolicarchbecameaforcesustainedbyasimplebeam,andthearcusplantaristendedtodisappear5andtobeflattened.clinically,240feetwithtalipesequinusweretreatedwithtriplearthrodesis.In34outofthereexamined156feet,theaponeurosisplantariswascutinadditiontothetriplearthrodesisandwasimmobilizedwithcastfor3months.Oneortwoyearslater,theirarcusplantarisdisappeared,paindevelopedwhenwalking,andsomeofthemwalkedwiththemidtarsaljointagainsttheground.Then,thetriplearthrodesisandshorteningoftheaponeurosisplantariswereappliedon18cases,andosteotomyofthecalcaneusandreconstructionoftheaponeurosisplantarisweremadeon10casesandsatisfactoryeffectswereobtained.Conclusions:Inordertoachievesatisfactorytherapeuticeffectsofthetriplearthrodesis,weshouldreestablishthearcusplantarisandaccuratelytreattheaponeurosisplantarisforthebalanceofthesurroundingmuscleforce.

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简介：Lidui(厉兑ST45)istheJing(井Well)pointoftheStomachMeridianofFoot-Yangming.It'seffectivetoreducetheheatfromthestomachortheStomachMeridian.TheStomachMeridianisabundantwithqiandblood,andisinchargeofhemopathy.So,inclinic,weoftenapplyLidui(ST45)pointbleedingmethodtothetreatmentofmanykindsofdiseasesandgetgoodtherapeuticeffects.Followingare3typicalcases.

简介：ECAPsarethesummaryofmultipleneurons’spikeswhichcouldberecordedbyabidirectionalstimulation-recordingsystemviathecochlearimplant,withtheartifacteliminationparadigmsofforward-maskingsubtractionparadigmoralternatingpolarityparadigm.ThreekindsofFDAapprovedcochlearimplantssupportECAPtesting.ThisarticleistosummarizetheclinicalapplicationofECAPlest.ECAPtestafterinsertionofelectrodeduringimplantoperationhasbeenwidelyusedduringcochlearimplantsurgery.Inrecentyears.ECAPthresholdsarealsousedtoestimatetheTlevelsandClevelshelpingprogramming.However,correlationbetweenECAPthresholdsandpsychophysicalthresholdsisaffectedbymanyfactors.Sofar,ECAPscannotyetbeagoodindicatorofpost-operativehearingandspeechperformance.

简介：Next-generationsequencing(NGS)isanewtechnologyusedforDNAandRNAsequencingandvariant/mutationdetection.NGScansequencehundredsandthousandsofgenesorwholegenomeinashortperiodoftime.Thesequencevariants/mutationsdetectedbyNGShavebeenwidelyusedfordiseasediagnosis,prognosis,therapeuticdecision,andfollowupofpatients.Thecapacityofitsmassiveparallelsequencingoffersnewopportunitiesforpersonalizedprecisionmedicine.

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简介：AbstractGastric cancer (GC) is one of the most common malignant tumors. The mechanism of how GC develops is vague, and therapies are inefficient. The function of microRNAs (miRNAs) in tumorigenesis has attracted the attention from many scientists. During the development of GC, miRNAs function in the regulation of different phenotypes, such as proliferation, apoptosis, invasion and metastasis, drug sensitivity and resistance, and stem-cell-like properties. MiRNAs were evaluated for use in diagnostic and prognostic predictions and exhibited considerable accuracy. Although many problems exist for the application of therapy, current studies showed the antitumor effects of miRNAs. This paper reviews recent advances in miRNA mechanisms in the development of GC and the potential use of miRNAs in the diagnosis and treatment of GC.

简介：AbstractBackground:It is a challenge to characterize the consciousness level of patients with severe disturbance of consciousness and predict their prognosis effectively for Chinese doctors. We aimed to investigate the psychometric property and the diagnostic practicality of severe disturbance of consciousness by Chinese Nanjing persistent vegetative state scale (CNPVSS) which was first set up in 1996 and modified in 2001 and 2011.Methods:The concurrent validity, inter-rater consistency and diagnostic accuracy of CNPVSS and Chinese version of coma recovery scale-revised (CRS-R) were investigated by assessment of 380 patients with severe disorders of consciousness.Results:Total scores of the CNPVSS were correlated significantly with that of the CRS-R, indicating acceptable concurrent validity. Sub-scale analysis showed moderate to high inter-rater reliability and test-retest reliability. CNPVSS was superior to CRS-R on the diagnosis sensitivity. The CNPVSS was able to distinguish 65 patients in emergence from minimal consciousness state who were misclassified as in minimal consciousness state (MCS) by the CRS-R, and it could also distinguish two patients in MCS who were misclassified as in vegetative state by the CRS-R.Conclusion:The CNPVSS is an appropriate measurement and is sensitive to distinguish the MCS patients from the VS patients.

简介：KONGRao-qi,male.bornin1944.Wasajuniorconsultantdoctor,astandingmemberandthedcputysecretary-generalofZhejiangProvincialAcupuncturcAssociation.thedirectorofZhejiangscalp-acupointcommittee,tichasbccnengagedinacupuncturepracticeformorethan30years.Withgreatattainmentsinthescalpacupuncture.Heishighlyskilledattheacupuncturetreatmentofapoplecticsequelae,

简介：BackgroundTheprognosticvalueofserumC-reactiveprotein(CRP)inpatientswithinfectiveendocarditis(IE)isnotwellelucidated.ThisstudyaimedtoevaluatetheusefulnessofCRPinpredictingtheoutcomeofIE.MethodsTwohundredninty-sixpatientsfrom2009to2012intheDepartmentofCardiologyatGuangdongGeneralHospitalwerescreenedanddividedintosurgicalandconventionaltreatmentgroups.CRP,whitebloodcell(WBC),erythrocytesedimentationrate(ESR)andotherclinicaldatawereobtainedwithfollow-upfor12months.ResultsTwohundredthirty-sixpatientswereassignedtoreceivesurgerytreatmentwhile60patientsreceivedconventionaltreatment.Inthesurgerygroup,thelevelofCRPinthedeathpatientswassignificantlyhigherthanthatinthesurvivalpatients(P<0.001).TheareaunderthecurveofROCwasabout0.749(SE0.064,P=0.005,95%CI,0.624-0.874)andthecut-offpointofCRPwas23.8mg/L.Inconventionalgroup,therewassignificantdifferencebetweendeathandsurvival(P<0.001).TheareaunderthecurveofROCwasabout0.701(SE0.095,P=0.032,95%CI,0.515-0.888)andthecut-offpointsofCRPwas65.6mg/L.TherewerenosignificantdifferencesinWBCandESRbetweensurgeryandconventionalgroups.ConclusionAmoreaggressivesurgicalinterventionresultsinabetteroutcomeoverconventionaltreatmentandCRPcouldbeservedasapredictivemarkerforadverseoutcomeinIEpatients.