简介：AIMToobservethetherapeuticeffectofmoxibustiononulcerativecolitisanditsinfluenceonthecolonicmucosalmorphology.METHODSForty-sixpatientswithulcerativecolitiswererandomlydividedintothemoxibustionwithherbalmedicineunderneathgroupandthewesternmedicinegroup.Thirtypatientsweretreatedwiththeabovemoxibustionand16patientswithSalicylayefapyridine(SASP).Thecolonicmucosaof13patientsinthemoxibustiongroupwasobservedbycolonoscopybeforeandafterthetreatment.MucinwasalsoanalyzedbyH.EandAB-PASstaining.RESULTSSeventeenpatientswereclinicallycured,12wereimprovedand1unchangedinthemoxibustiongroup.Inthecontrolgroup,5patientswereclinicallycured,7improvedand4unchanged.ThirteenpatientswithactiveUCweretakenasthesubjectsforhistopathologicanalysisinthisstudy.Thecolonicmucosallesionswereremarkablyimprovedandthecharacteristicofthemucinalsochanged.Inmostsections,thechronicinflammationofmucosawasgeatlyameliorated(P<0.01).Theinflammatorycellinfiltratationmuchdecreasedandneutrophils,disapearedinmostsections(P<0.001).Thegobletcellssignificantlyincreased(P<0.001);cryptparacryptabscessormucosalulcerationwasseen(P<0.001).CONCLUSIONTherateofcureofulcerativecolitisbymoxibustionwithherbalmedicinebeneathissuperiortothatbySASP.Thissortofmoxibustioncaneffectivelyimprovethecolonicmucosallesionsandrestoretheproportionofmucoproteintonearnormal.

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简介：结肠的静脉曲张是更低的胃肠的流血的一个很稀罕的原因。少数在英语文学比自发的结肠的静脉曲张(ICV)的结肠的静脉曲张，和30个案例的100个案例被报导了。在ICV的这30个案例之中，19个案例被血管造影术诊断，并且7个操作案例以后作为回盲肠静脉赤字被诊断，缝血管瘤，并且在1自发，1，5个案例分别地。我们报导受不了在11年岁时改变学位的便血的多重事件的一个24岁的人的案例。他与21g/L的血红素有严重贫血症。在结肠镜检查上，曲折地扩大了特别在书籍的右页sigmoid区域被黑暗坏死的纸巾盖住的粘膜下层静脉和脆的溃疡从直肠被看见直到远侧的下降结肠。它开始看起来是有静脉曲张的癌。肠系膜angiographic学习建议了一个结肠的缝血管瘤。低前面的切除术由于难处理的医学上和周期性的便血被做。另外的肠和mes伤寒脉管的结构显得正常。没有代表新容器生长，显微镜检查在整个粘膜下层和浆膜与扩大静脉揭示了正常结肠的粘膜。一起这些调查结果拿所有，病人作为ICV被诊断。他的手术后的功课是平静的。

简介：AIMTounderstandtheinfluenceoffrailtyonpostoperativeoutcomesforlaparoscopicandopencolectomy.METHODSDatawereobtainedfromtheNationalSurgicalQualityImprovementProgram(2005-2012)forpatientsundergoingcolonresection[opencolectomy(OC)andlaparoscopiccolectomy(LC)].Patientswereclassifiedasnon-frail(0points),lowfrailty(1point),moderatefrailty(2points),andseverefrailty(≥3)usingtheModifiedFrailtyIndex.30-dmortalityandcomplicationswereusedastheprimaryendpointandanalyzedfortheoverallpopulation.Complicationsweregroupedintomajorandminor.Subsetanalysiswasperformedforpatientsundergoingcolectomy(totalcolectomy,partialcolectomyandsigmoidcolectomy)andseparatelyforpatientsundergoingrectalsurgery(abdominoperinealresection,lowanteriorresection,andproctocolectomy).WeanalyzedthedatausingSASPlatformJMPProversion10.0.0(SASInstituteInc.,Cary,NC,UnitedStates).RESULTSAtotalof94811patientswereidentified;themajorityunderwentOC(58.7%),werewhite(76.9%),andnon-frail(44.8%).Themedianagewas61.3years.Prolongedlengthofstay(LOS)occurredin4.7%,and30-dmortalitywas2.28%.PatientsundergoingOCwereolder(61.89±15.31vs60.55±14.93)andhadahigherASAscore(48.3%ASA3vs57.7%ASA2intheLCgroup)(P<0.0001).Mostpatientswerenon-frail(42.5%OCvs48%LC,P<0.0001).Complications,prolongedLOS,andmortalityweresignificantlymorecommoninpatientsundergoingOC(P<0.0001).OChadahigherriskofdeathandcomplicationscomparedtoLCforallfrailtyscores(non-frail:OR=4.7,andOR=4.67;mildlyfrail:OR=2.51,andOR=2.47;moderatelyfrail:OR=2.94,andOR=2.02,severelyfrail:OR=2.37,andOR=2.34,P<0.05)andanincreaseinabsolutemortalitywithincreasingfrailty(non-frail0.68%OC,mildlyfrail1.39%,moderatelyfrail3.44%,andseverelyfrail5.83%,P<0.0001).CONCLUSIONLCisassociatedwithimprovedoutcomes.Althoughtheoddsofmortalityarehigherin

简介：AIMToinvestigatetheeffectofgingeroloncolonicmotilityandtheactionofL-typecalciumchannelcurrentsinthisprocess.METHODS：ThedistalcolonwascutalongthemesentericborderandcleanedwithCa^2＋-freephysiologicalsalinesolution.MusclestripswereremovedandplacedinCa^2＋-freephysiologicalsalinesolution,whichwasoxygenatedcontinuously.Longitudinalsmoothmusclesampleswerepreparedbycuttingalongthemusclestripsandwerethenplacedinachamber.Mechanicalcontractileactivitiesofisolatedcolonicsegmentsinratswererecordedbya4-channelphysiograph.Colonsmoothmusclecellsweredissociatedbyenzymaticdigestion.L-typecalciumcurrentswererecordedusingtheconventionalwhole-cellpatch-clamptechnique.RESULTS：Gingerolinhibitedthespontaneouscontractionofcoloniclongitudinalsmoothmuscleinadose-dependentmannerwithinhibitionpercentagesof13.3%±4.1%,43.4%±3.9%,78.2%±3.6%and80.5%±4.5%at25μmol/L,50μmol/L,75μmol/Land100μmol/L,respectively（P〈0.01）.Nifedipine,anL-typecalciumchannelblocker,diminishedtheinhibitionofcolonicmotilitybygingerol.GingerolinhibitedL-typecalciumchannelcurrentsincoloniclongitudinalmyocytesofrats.Ata75μmol/Lconcentrationofgingerol,thepercentageofgingerolinducedinhibitionwasdiminishedbynifedipinefrom77.1%±4.2%to42.6%±3.6%（P〈0.01）.GingerolsuppressedIBainadose-dependentmanner,andtheinhibitionrateswere22.7%±2.38%,35.77%±3.14%,49.78%±3.48%and53.78%±4.16%ofcontrolat0mV,respectively,atconcentrationsof25μmol/L,50μmol/L,75μmol/Land100μmol/L（P〈0.01）.Thesteady-stateactivationcurvewasshiftedtotherightbytreatmentwithgingerol.Thevalueofhalfactivationwas-14.23±1.12mVinthecontrolgroupand-10.56±1.04mVinthe75μmol/Lgroup（P〈0.05）withslopefactors,Ks,of7.16±0.84and7.02±0.93（P〈0.05）inthecontroland75μmol/Lgroups,respectively.However,thesteady-st

简介：Steadystateandtime-resolvedautofluorescencespectroscopiesareemployedtostudytheautofluorescencecharacteristicsofhumancolonictissuesinvitro.Theexcitationwavelengthvariesfrom260to540nm,andthecorrespondingfluorescenceemissionspectraareacquiredfrom280to800nm.Significantdifferenceinfluorescenceintensityofexcitation-emissionmatrices(EEMs)isobservedbetweennormalandtumorcolonictissues.Comparedwithnormalcolonictissue,lownicotinamideadeninedinucleotide(phosphate)(NAD(P)H)andflavinadeninedinucleotide(FAD),andhighaminoacidsandprotoporphyrinIX(PpIX)fluorescencescharacterizehigh-grademalignanttissue.Moreover,theautofluorescencelifetimesofnormalandcarcinomatouscolonictissuesat635nmunder397-nmexcitationareabout4.32±0.12and18.45±0.05ns,respectively.ThehighaccumulationofendogenousPpIXincoloniccancersisdemonstratedinbothsteadystateandtime-resolvedautofluorescencespectroscopies.更多还原

简介：瞄准：比nonsteroidal评估风险因素其它反煽动性的药为在一张西洋化的人口的结肠的憩室的流血。方法：140个病人，在一个社区为征兆的憩室的疾病对待基于的医院，被包括。(21%)三十有憩室的流血的符号。colonoscopy的年龄，性，和结果被收集并且与有非为征兆的憩室形成放血的一组病人相比。记录为comorbidities被考察，例如肥胖，白酒消费，吸烟习惯和新陈代谢的疾病。特殊强调被放在动脉的高血压，心血管的事件，糖尿病mellitus，hyperuricemia和hypercholesterinemia上。结果：与非关于性比率(男性/女性的9/21对47/63)和憩室的本地化为征兆的憩室形成放血有憩室的出血和那些的病人之间没有差别。流血病人在尊重不同变老(73.4+/-9.9对67。8+/-13.0，P<0.013)。重要差别关于hyperuricemia的存在在两个组之间被发现并且类固醇和nonsteroidal使用反煽动性的药。有新陈代谢的疾病也是的三伴随物的病人作为在流血的风险识别了。向前逐步的逻辑回归分析表明类固醇，hyperuricemia和钙隧道的使用作为流血的独立风险因素堵住ers。结论：在nonsteroidal旁边反煽动性的类固醇药使用，反高血压的药和伴随物动脉硬化的疾病是为结肠的憩室的出血的风险因素。我们的结果作为流血的来源支持一个改变的动脉硬化的容器的假设。

简介：目的：观察针灸对溃疡性结肠炎（ulcerativecolitis，UC）大鼠结肠黏膜胰岛素样生长因子1（insulin-likegrowthfactor-1，IGF-1）和细胞因子信号转导抑制因子-2（suppressorofcytokinesignaling，SOCS2）表达的影响，探讨针灸治疗UC的作用机理。方法：将大鼠随机分为正常组、模型组、隔药灸纽和电针组，每组8只，采用免疫学方法加局部刺激制备UC大鼠模型。隔药灸组和电针组分别进行隔药灸和电针治疗，每目1次，连续治疗14d。光镜观察大鼠结肠黏膜形态学变化，采用PAS—AB、HID—AB染色观察结肠黏膜粘蛋白，免疫组织化学技术检测大鼠结肠黏膜IGF-1和SOCS2表达。结果：光镜下可见UC大鼠结肠溃疡形成和炎症，结肠黏膜粘蛋白减少（P〈0．01），IGF-1表达升高（P〈0．01），SOCS2表达降低（P〈0．01）；隔药灸、电针治疗后，结肠黏膜病理损伤减轻，粘蛋白增加（P〈0．01），IGF-1表达降低（P〈0．01），SOCS2表达升高（P〈0．01）。结论：UC大鼠结肠黏膜粘蛋白分泌减少，IGF-1表达升高、SOCS2表达下降；隔药灸、电针能改善UC大鼠结肠黏膜损伤，调节结肠粘蛋白的分泌及IGF-1和SOCS2的表达。