简介:摘要:利用常规天气观测资料、 NCEP6 h再分析资料,应用天气学原理分析方法,对 1963年 4月 1日、 1966年 4月 1日两场春季强寒潮降温天气进行分析。结果表明: 1)寒潮爆发前期的能量的积累是寒潮爆发时降温幅度的一项重要指标 ,前期的能量积累是主要依靠地表较强的增温以及锋前暖平流共同影响造成,前期的迅速回暖导致寒潮爆发的烈度加剧。( 2) 100hpa环流形势上可以看出,两次寒潮过程中,都是由极涡中心呈偶极型东移南下突破 70°N线对博州造成寒潮天气。( 3) 500hpa环流形势上,两场天气的环流都是典型是倒 Ω型,从主导系统的演变上看, 1963年 4月 1日寒潮天气可以归类为是由于欧洲脊的东南垮,引导冷空气南下。而 1966年 4月 1日寒潮天气则归为里咸海长脊类。( 4)从地面冷锋位置与低层温度平流强度上来看,同为槽区西部为暖平流,且愈向底层暖平流越强,根据位势倾向方程可知,当暖平流随高度减弱时,等压面高度升高,使得高层出现正变高,促使主导系统进一步的发展;而槽区东部为冷平流,并且冷平流随高度的升高而减弱,使得高层出现负变高,使得槽东部加深发展。
简介:摘要患儿女,5岁3月龄,因肢体无力3个月余入院,生长发育落后于同龄儿、严重酸中毒,低钾血症;双眼玻璃体混浊,角膜基质灰白混浊;头颅磁共振成像示双侧基底节区可见对称性斑片状致密影。基因检测发现患儿SLC4A4基因外显子区域存在1个c.145C>T杂合变异,与其父检测结果一致;内含子区域存在一个c.1499+1G>A杂合变异,与其母检测结果一致。患儿以严重的代谢性酸中毒为特点,且伴有多系统病变,应注意先天遗传代谢性疾病,尽早行基因检测。
简介:摘要:K4往复式给煤机在使用中存在减速机输出轴曲柄连接销轴发生断裂的问题以及对轮销轴断裂的问题,对安全生产造成中断浪费人力物力,对其进行改造克服这两点问题,自制压板通过螺栓压紧曲柄增大摩擦力,从而减少曲柄连接销轴发生断裂;改变对轮连接方式,利用废旧皮带加工成特殊形状连接对轮凸缘,利用皮带的韧性和强度来传动,杜绝了对轮销轴断裂的问题。
简介:AbstractObjective:The immune system is involved in the pathogenesis of schizophrenia; here, we aimed to explore the relationship of cytotoxic T lymphocyte antigen 4 (CTLA4) with schizophrenia.Methods:CTLA4 gene structure was first analyzed, and then rs231779, rs733618, rs231775 and rs3087243 were selected as tag single nucleotide polymorphisms for the linkage disequilibrium blocks in CTLA4 in the Chinese Han population to study expression quantitative trait loci of CTLA4 gene in normal brain tissue. Additionally, membrane CTLA4 (mCTLA4) and soluble CTLA4 (sCTLA4) mRNA expression levels were evaluated in peripheral blood mononuclear cells from 65 first-episode schizophrenia patients and 61 healthy controls. This study was approved by the Bioethics Committee of corresponding research institutes (approval No. 20150016) on March 6, 2015 and the principles of the Declaration of Helsinki.Results:After applying Bonferroni correction to the P values, only the minor C allele of rs733618 was significantly associated with increased expression of total CTLA4 (PBonf.= 0.019), but not mCTLA4 (PBonf. = 0.115), in the hippocampus. The sCTLA4 expression was significantly decreased in the peripheral blood mononuclear cells of schizophrenia patients compared with healthy controls, while mCTLA4 was not.Conclusion:These results suggest that the soluble form of CTLA4 may be associated with schizophrenia and that lower sCTLA4 expression may increase the risk of developing schizophrenia.