简介:AbstractBackground:Mastectomy techniques have been extended to nipple-sparing mastectomy (NSM). This study aimed to assess the actual application of NSM in China and identify the factors influencing postoperative complications.Methods:The clinical data of 615 patients (641 surgeries) undergoing NSM from January 1st, 2018 to December 31st, 2018 at 28 centers nationwide were retrospectively analyzed to obtain the rate of NSM and investigate factors related to NSM surgery.Results:The proportion of NSM surgery performed in this study was 2.67% (17/641). Malignant breast tumors accounted for the majority of NSM surgery (559/641, 87.2%). A total of 475 (77.3%) patients underwent NSM combined with reconstructive surgery. The rate of reconstruction decreased with age in our study, and implants were the most common option (344/641, 53.7%) in reconstruction. Radial incision was the most selected method regardless of reconstruction. However, for those who underwent reconstruction surgery, 18.4% (85/462) of cases also chose curvilinear incision, while in the simple NSM surgery group, more patients chose circumareolar incision (26/136, 19.1%). The tumor-to-nipple distance (TND) influenced postoperative complications (P = 0.004). There were no relationships between postoperative complications and tumor size, tumor location, histologic grade, molecular subtype, nipple discharge, and axillary lymph nodes.Conclusions:NSM surgery is feasible and only TND influenced postoperative complications of NSM surgery. But the proportion of NSM surgery performed is still low in nationwide centers of China. The selection criteria for appropriate surgical methods are important for NSM in clinical practice. To optimize clinical applications of NSM, further multicenter prospective randomized controlled studies are needed.Trial Registration:ChiCTR.org.cn, ChiCTR1900027423; http://www.chictr.org.cn/showprojen.aspx?proj=38739
简介:摘要:随着石油开采技术的不断发展,低渗透油藏的高效开发成为石油行业面临的重要挑战之一。红003井区作为典型的低渗透油藏区域,原油粘度较高,传统开采方法在提高产量方面面临诸多限制。纳米技术的兴起为解决这一问题带来了新的机遇。纳米材料具有独特的物理和化学性质,其在降低原油粘度方面展现出巨大潜力。因此,研究红003井区纳米降粘增产措施技术的应用具有重要的现实意义。基于此,以下对红003井区纳米降粘增产措施技术应用及效果进行了探讨,以供参考。
简介:摘要目的探讨翻译起始因子uc003yoa.3对肝细胞癌(肝癌)肝切除术后生存的影响及其在肝癌细胞增殖中的作用。方法回顾性分析2010年3月至4月东方肝胆外科医院行肝切除的215例患者临床资料。患者均签署知情同意书,符合医学伦理学规定。其中男182例,女33例;年龄30~76岁,中位年龄49岁。采用基因芯片分析5例患者肝癌及配对癌旁组织uc003yoa.3 mRNA的表达。RT-PCR检测siRNA干扰后SMMC7721肝癌细胞uc003yoa.3 mRNA表达,CCK-8检测细胞增殖。多组uc003yoa.3 mRNA比较采用单因素分析和LSD-t检验。采用Kaplan-Meier法绘制生存曲线,Log-rank检验进行生存分析,Cox比例风险模型分析生存预后独立危险因素。结果基因芯片检测显示肝癌组织样本中uc003yoa.3 mRNA表达明显高于癌旁组织(Fold change=3.654,P<0.05)。uc003yoa.3-siRNA作用SMMC7721肝癌细胞4 d后,uc003yoa.3 mRNA表达量为0.14±0.04,明显低于对照组的0.22±0.06 (LSD-t=-1.119,P<0.05) ;SMMC7721增殖抑制率52%。Cox多因素分析显示,uc003yoa.3高表达、AFP>20 μg/L、肿瘤直径>5 cm、卫星灶是影响肝癌患者无瘤生存的独立危险因素(HR=1.979,1.841,2.539,2.358;P<0.05)。uc003yoa.3高表达及肿瘤直径>5 cm是影响肝癌患者肝切除术后总体生存的独立危险因素(HR=1.927,2.134;P<0.05)。结论uc003yoa.3在肝癌中高表达,可促进肝癌细胞恶性表型增加,且是影响肝癌肝切除术后长期生存的独立危险因素。