简介:BasedontheMiedemamodelandExtendedMiedematheory,theformationenergiesofdifferentsolutecomponentsinEr-XbinarysystemandAl-Er-Xternarysystemswerecalculated.TheresultsshowthatthevariationoferbiumcontenthaslittleinfluenceonthechancerateoftheformationAl-ErcompoundintheAl-Mg-Mn-Zr-Ersystem.ThecalculatedformationenergiesintheEr-XbinarysystemandAl-Er-XternarysystemsindicatethatAl3Erphasecantakepriorityofdepositing,Al-Er-Zrternarycompoundsmayalsofoundwhichagreeswiththeexperimentalresultsinreferences.TheconsistencyofcalculationandexperimentprovesthattheintermetalliccompoundsintheAl-Mg-Mn-Zr-ErsystemcanbepredicteddirectlybycalculatingtheformationenergiesofthereactionsinEr-XbinarysystemandAl-Er-XternarysystemswiththeMiedemamodelandExtendedMiedematheory.
简介:目的探讨雌激素受体β(ERβ)及其异构体(ERβ1、ERβcs)在人类表皮生长因子受体2(HER-2)阳性与阴性乳腺癌组织中的表达差异,分析其与雌激素受体α(ERα)、孕激素受体(PR)表达及临床分期和腋窝淋巴结状况的关系。方法采用简单随机抽样的方法选择中山大学附属第一医院2004年12月至2007年12月收治的HER-2高表达(卅)51例与无表达(一)53例乳腺浸润性导管癌病例,分别检测乳腺癌组织的ERα、ERβ、ERβ1、ERβcx及PR表达水平,分析其相互关系及与肿瘤临床分期、腋窝淋巴结转移等临床指标的相关性。采用x^2检验对HER-2(卅)组与(一)组淋巴结表达情况进行对比分析,对HER-2(卅)及HER-2(一)组内各指标采用Spearman相关性分析。结果在HER-2(卅)与(一)两组中临床分期及淋巴结转移率差异均无统计学意义(P〉0.050);HER-2(卅)组ERα、ERβ1、ERβcx、PR的阳性表达率均低于HER-2(一)组,差异均有统计学意义(P〈0.050)。HER-2(卅)组中,ERβ1与ERα的表达、ERβcx与PR的表达均呈正相关(P〈0.050),但ERG、ERβ1及ERβx均未显示与淋巴结转移状况及临床分期相关(P〉0.050)。HER-2(一)组中,HEβ1及ERβcx的表达均与ERα、ERβ1、ERβ、PR呈正相关(P〈0.050),但ERα、ERβ、ERβ1及ERβcx均与淋巴结转移情况及临床分期无显著相关性(P〉0.050)。结论ERβ1和ERβcx可能作为乳腺癌预后良好的指标,有必要进一步研究其与乳腺癌治疗后的生存关系。
简介:摘要目的探讨乳腺癌组织中雌激素α受体(ERα)和雌激素β受体(ERβ)蛋白表达对乳腺癌诊断的意义。方法用免疫组化SP法检测85例乳腺癌组织和32例癌旁正常组织中ERα和ERβ蛋白的表达情况。结果乳腺癌组ERα蛋白阳性表达率(75.3%)高于癌旁正常组(28.1%),P=0.001;乳腺癌组ERβ阳性表达率(52.9%)低于癌旁正常组织(78.1%),P=0.013;ERα和ERβ阳性表达均与组织学分级有关,高分化组ERα阳性表达率高于中、低分化组,P=0.035,而高分化组ERβ阳性表达率明显低于中、低分化组,P=0.042;但ERα和ERβ阳性表达均与肿瘤大小、临床分期、有无淋巴结转移无关(P>0.05)。结论ERα在乳腺癌的发生、发展过程中发挥着重要作用,ERβ随细胞恶变发生改变,联合检测ERα和ERβ对乳腺癌的诊断、治疗及预后判断有一定意义。
简介:IfbeingaskedwhichisthelargestcityofYunnan,nineoutoftenpeoplewouldgivethewronganswer-justassomepeoplewouldreplythatTorontoisthecapitalofCanada,SydneyisthecapitalofAustraliaandGuilinisthecapitalofGaungxi.Infact,thelargestcityofYunnanisPu’er,notKunming.ManypeoplearefamiliarwithPu’erbecauseofPu’erTea.Theybelievetheplace'Pu’er'isnamedafterthetea.Butthe
简介:Er~(3+)-dopedphosphor-telluriteglassforbroadbandshort-lengthEr~(3+)-dopedfiberamplifier(EDFA)isfabricatedandcharacterized.Thedifferentialvalue(△T)ofonsetcrystallinetemperature(T_x)andglasstransitiontemperature(T_g)is206°C.ThestimulatedemissioncrosssectionofEr~(a+)iscalculatedfromab-sorptionspectrumbyMcCumbertheoryandis0.87×10~(-20)cm~2at1532nm.Abroad1.5-μmfluorescencespectrumwith54-nmfull-widthathalfmaximum(FWHM)isdemonstrated.Especially,themaximumphononenergyofundopedphosphor-telluriteglassis1100cm~(-1),whichrestrictstheupconversionlumines-cence.Itispossibletopumpefficientlyat980nm.TheseresultsindicateEr~(3+)-dopedphosphor-telluriteglassissuitableforfabricatingbroadbandshort-lengthEDFA.
简介:Hirschsprungs疾病是现场发生在1:5000的先天的混乱出生。它被伤寒神经原的缺席沿着胃肠的道的一个可变区域描述。Hirschsprungs疾病作为multigenic混乱被分类,因为一样的显型在多重不同基因与变化被联系。而且,Hirschsprungs疾病的遗传高度复杂、不严格地孟德尔。在Hirschsprungs疾病观察的phenotypic可变性和不完全的外显率也建议修饰词基因的参与。这里,我们总结基于人和动物研究位于Hirschsprungs疾病下面的遗传的当前的知识,集中于修饰词基因的主要原因的基因,他们的相互作用,和角色。
简介:CyclicvoltammetryandchronoamperometrywereusedtoinvestigatetheclectrochemicalbehaviorofFe(Ⅱ)andEr(Ⅲ)inaLiClO4-DMSO(dimethylsufoxide)systematPtandCuelectrodes.ExperimentalresultsindicatethatthereductionsofFe(Ⅱ)toFe(0)andEr(Ⅲ)toEr(0)wereirreversibleatPtandCuelectrodes.ThediffusioncoefficientandtheclectrontransfercoeffieientofFe(Ⅱ)ina0.01mol/LFeCl2-0.1mol/LLiClO4-DMSOsystemat303Kwere1.70×10^-10m^2/sand0.08respectively,thediffusioncoeffieientandtheelectrontransfercoefficientofEr(Ⅲ)ina0.01mol/LErCl3-0.1mol/LLiClO4-DMSOsystemat303Kwere1.47×10^-10m^2/sand0.108respectivealy.Thehomogeneous,strongadhesiveEr-FealloyfilmscontainingErof31.39%-42.12%inmassfractionwithmetalliclustrewerepreparedbypotentiostaticelectrolysisonaCuelectrodeinaErCl3-FeCl2-LiClO4-DMSOsystemat-1.75—-2.05V(vs.SCE).
简介:(EC+β+)Decayof153Erand157Yb¥XuShuwei;XieYuanxiang;PanQiangyan;ZhangJuping;ZhangXueqian;WangYihao;GeYuanxiu;YinXijin?..
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简介:ThemethodtopumptheFBGwrittenintoanEr3+-dopedopticalfiberisproposedtoincreasethegroupvelocityofaprobingpulsebasedonthefactsthatpump-inducedprocesschangestherefractiveindexanddispersionassociatedwiththe4I15/2-4I13/2transitioninEr3+-dopedopticalfiber.Thesystemequationsarederived.Theeffectsofpumppoweranddopingconcentrationonthegroupvelocityarediscussed.