简介:1.IntrodnctionThispaperextendsthestudyofthesingularmatrixvariatebetadistributionofrank1[1]tothecaseofageneralrank.Astherelateddistributiontonormalsampling,thematrixvariatebetadistribution(alsocalledthemultivariatebetadistribution)hasbeenstudiedextens...
简介:Aprobabilitydensityfunction(PDF)isderivedofbetadistributionwithbothλ3(skewness)andλ4(kurtosis)asparametersforweaklynonlinearwavesurfaceelevationbyuseofamethodrecentlyproposedbySrokosz.ThisPDFnotonlyhasasimplerformthanthewell-knownGram-CharlierSeriesPDFderivedbyLonguet-Higgins,butalsoovercomesanobviousshortcomingofthelatterthatwhentheseriesisunsuitablytruncated,theresultingPDFislocallynegative.TotestthederivedbetaPDF,laboratorialexperimentsofwindwavesareconducted.TheexperimentaldataindicatethatthetheoreticalrequirementsoftheparametersinthebetaPDFarefulfilled.TheexperimentalresultsshowthatthepresentPDFisinbetteragreementwiththemeasureddatathanthebetaPDFonlyincludingparameterλ3,andalsothantheGram-CharlierSeriesPDFtruncateduptothetermofH6.
简介:趋势科技近日在其网站上推出企业桌面安全解决方案趋势科技OfficeScan7.8beta版,该产品将随着WindowsVista的问世而为其提供防病毒和其他保护。WindowsVista是Windows客户端操作系统的下一代产品。趋势科技OfficeScan可以保护企业的WindowsVista计算机免遭病毒和恶意代码攻击,包括文件病毒、宏病毒和恶意间谍软件、JavaApplet以及ActiveX控制。面向WindowsVistabeta版的趋势科技OfficeScanbeta版是在2006年5月参加微软的技术采纳计划(TAP)最先推出的,现在可以通过趋势科技的公开网站立即下载OfficeScan7.8beta版。
简介:AbstractThalassemia, classified as the main types α- and β-thalassemia, is a single gene disorder resulting from globin chain synthesis impairment through the mutation or deletion of globin genes. The incidence of thalassemia is high worldwide, with high associated mortality. Therefore, treatment is important to improve patient outcomes. This paper reviews the current status of β-thalassemia major in China, including its epidemiology and treatment.
简介:摘要目的探讨供血动脉介入栓塞对于颅内富血供肿瘤的治疗价值。方法回顾性分析复旦大学附属华山医院神经外科自2019年3月至2022年8月行开颅手术切除前供血动脉介入栓塞的45例颅内富血供肿瘤患者资料,总结其肿瘤影像学特点、病理类型、术前栓塞指征、栓塞效果和栓塞相关并发症,从而评估术前介入栓塞治疗的安全性和有效性。结果45例患者中21例为血管母细胞瘤,15例为脑膜瘤,5例为血管外皮瘤,4例为颈静脉球瘤。介入栓塞技术成功率达97.8%(44/45),其中1例脑膜中动脉过于迂曲,栓塞微导管无法到位。介入栓塞成功病例中,41例患者采用液体栓塞剂Onyx,3例采用液体栓塞剂NBCA。完全栓塞7例,大部栓塞26例,部分栓塞11例。出现栓塞相关并发症共4例,其中2例脑膜中动脉破裂出血,1例Marathon微导管无法拔出,1例功能型颈静脉球瘤术中发生嗜铬细胞瘤危象。该4例患者术中均及时处理,未造成严重后果。结论对于颅内富血供肿瘤,术前介入栓塞安全有效,但需严格掌握介入手术指征并选择合理的栓塞方式和栓塞材料。
简介:摘要目的探讨老年髋部骨折患者术前低氧血症的危险因素。方法采用病例对照研究分析2020年11月至2021年8月东南大学附属中大医院收治的99例老年髋部骨折患者临床资料,其中男29例,女70例;年龄67~96岁[(82.6±6.2)岁]。以急诊就诊时吸入室内空气下动脉血氧分压(PaO2)<80 mmHg为参考标准,分为低氧血症组(51例)和非低氧血症组(48例)。比较两组性别、年龄、骨折类型、体重指数(BMI)、美国麻醉师协会(ASA)分级、术前胸部CT诊断的肺部疾病[肺不张、胸腔积液、慢性阻塞性肺疾病(COPD)]、受伤至就诊时间、美国纽约心脏协会(NYHA)心功能分级、Barthel指数、KATZ指数、改良版英国医学研究委员会(mMRC)呼吸困难评分、数字疼痛评分(NRS)、吸烟、饮酒、基础疾病(高血压、糖尿病、帕金森病、阿尔兹海默症、既往脑梗死、冠心病)、体温、首次血常规检查(红细胞计数、白细胞计数、C-反应蛋白、血红蛋白)、生化检查(血清白蛋白、血糖、血肌酐、血尿素氮)、电解质检查(血钠、血钾)及其他相关检查[D-二聚体、心房钠尿肽(BNP)、乳酸]。采用单因素分析上述指标与术前低氧血症的相关性,采用多因素Logistic回归分析明确老年髋部骨折术前低氧血症的独立危险因素。结果两组性别、年龄、骨折类型、BMI、术前CT诊断的肺部疾病、受伤至就诊时间、Barthel指数、KATZ指数、NRS、吸烟、饮酒、基础疾病、体温、首次红细胞计数、生化检查、电解质检查、其他相关检查差异无统计学意义(P均>0.05);ASA分级、NYHA心功能分级、mMRC呼吸困难评分、首次白细胞计数、C-反应蛋白及血红蛋白差异有统计学意义(P均<0.05)。单因素分析结果显示,ASA分级、NYHA心功能分级、mMRC呼吸困难评分、首次白细胞计数、C-反应蛋白与老年髋部骨折术前低氧血症有一定相关性(P均<0.05)。多因素Logistic回归分析结果表明,mMRC呼吸困难评分高(OR=2.30,95%CI 1.10~4.81,P<0.05)、白细胞计数高(OR=1.24,95%CI 1.05~1.45,P<0.05)、C-反应蛋白水平高(OR=1.02,95%CI 1.01~1.03,P<0.05)和血红蛋白水平高(OR=1.04,95%CI 1.01~1.07,P<0.05)与老年髋部骨折术前低氧血症显著相关。结论高mMRC呼吸困难评分、高白细胞计数、高水平C-反应蛋白及高水平血红蛋白是老年髋部骨折术前低氧血症的独立危险因素。
简介:ObjectivesToinvestigatetheeffectsoftestosteroneenanthate(TE)onserumlipidsandlipoproteinsmetabolismandtheexpressionofandrogenreceptor(AR),estrogenreceptorbeta(ER-β)andplateletderivedgrowthfactorbeta(PDGFR-β)inaorticvascularsmoothmuscletissues(VSMTs).MethodsFortyagedmaleratswererandomlydividedinto4groups,groupA(placebogroup),groupB(2.5mg/kgintramuscularinjectionofTEonceaweek),groupC(5.0mg/kgintramuscularinjectionofTEonceaweek),groupD(10.0mg,/kgintramuscularinjectionofTEonceaweek).Allanimalswerefedfreelyduring16-weektreatmentperiods.TheexpressionofAR,ER-βandPDGFR-βwerestudiedbyWesternbolt.ResultsAverageserumLDL-CwasloweringroupDthanthatingroupA(p<0.01).Comparedwiththeothergroups,averageserumTCwasalsoloweringroupD(p<0.05).ARexpressioninaorticvascularsmoothmuscletissuescouldberegulatedbyTE:99.50±21.74,125.38±28.68and101.98±15.42forTEconcentrationsat2.5mg/kg,5.0mg/kgand10.0mg/kg,respectively,theexpressionofER-βcouldberegulatedbyTE:92.34±18.68,47.72±18.12,82.13±23.50,andtheexpressionofPDGFR-βcouldberegulatedaswellbyTE:219.70±45.59,50.16±9.72,125.36±15.74(DataforAR,ER-βandPDGFR-βproteinbandintensitywereexpressedwithx±s,withcontrolgrouptakenas100).ConclusionsThisstudyindicatesthatandrogenshavesignificanteffectsonserumlipidsandlipoproteinmetabolism.Testosteroneenanthateat5.0mg/kgcanstimulatetheexpressionofAR,butinhibitetheexpressionofPDGFR.Testosteroneenanthateattheconcentrationsof5.0mg/kgand10.0mg/kgcaninhibitetheexpressionofER-β.
简介:Inthepresentpaper,weproposetheqanalogueofSza′sz-Beta-Stancuoperators.Byestimatethemoments,weestablishdirectresultsintermsofthemodulusofsmoothness.Investigatetherateofpoint-wiseconvergenceandweightedapproximationpropertiesoftheqoperators.Voronovskajatypetheoremisalsoobtained.Ourresultsgeneralizeandsupplementsomeconvergenceresultsoftheq-Sza′sz-Betaoperators,thustheyimprovetheexistingresults.
简介:Texturepatternmappingisoneofthemostimportanttechniquesforhighqualityimagesyn-thesis.Itcanlargelyenhancethevisualrichnessofraster-scanimages.Inthispaperispresentedanewmethodofmappingplanartexturepatternontobeta-splinecurvedsurfaces——bilinearmappingmethodwhichcanmapplanartexturepatternontocurvedsurfaceswithlessdistortion,andalsocanfulfillthegeometrictransformationofthetexturepatternonthecurvedsurfacesbyoperatingthepatternwin-dow.ItisvaluabletobothCAD/CAMinartisticfieldandcomputergraphics.