简介：艺术欣赏的本质是对艺术的感觉和理解，音乐欣赏也是如此，是从感知到理解的高度升华，门德尔松是19世纪上半叶德国伟大的作曲家之，他与肖邦、舒曼同为浪漫主义时代的三位杰出代表。无词歌是我们了解门德尔松音乐的标志，它创作于1828年，由其姐姐芳妮率先称之为无词歌，并赞美为“绝妙的小品”。音乐就是这样，虽然没有刻意的歌词，没有故意的描绘，但我们还是呵以感受到作曲家感情的真挚流露和异乎寸常的渲染，这就是门德尔松给了，我们无言的丰楹启示。

简介：秋日的大街，寂寞、荒凉。当天际出现y一抹玫瑰色时，路上的鸣笛声也开始显得单调乏味，行人也慢慢减少。

简介：雪花飞扬的冬日装饰了诗人眼里的诗情画意．与冷冽的寒风相映衬，没有一丝暧意，但它却比生机盎然的春天更唯美。比骄阳酷暑的夏天更温幂．比冷风萧瑟的秋天更潇洒．因为它有一种平易近人的美，瞧!那朵晶莹的雪花在与你窃窃私语……

简介：深秋的俄罗斯一派金色的窃窃私语。动态的如大片大片立着足尖跳芭蕾般的白桦树林,当微风吹来,它们就婆娑起舞。静态的如油画般的枫树,叶子由碧绿渐变为金黄直至金红,层层叠叠铺向很远很远的地方。而这个民族在艺术上达到极致的,恰好是芭蕾和油画。还有音乐和文学。夜晚,住在中国驻俄罗斯大使馆。对面是一片美丽的树林,白天无数次路过但无暇走进去领略它

简介：秋游的人群散落山水各处乌鸦一般小和黑一队队白鹅走到浮云上，大路朝天洛湛铁路的火车，开入湛蓝的大海

简介：夏去秋来，秋季是一年中体感最舒服的季节。不过天气凉爽了，人也很容易变得懒惰，尤其对于减肥中的女士们来说，苦夏过后，很容易就会在秋季“滋补”的概念下养成好吃懒做的状态，这就很容易造成秋日虚胖的情况。为了不让夏天的减肥成果付之东流，今天小编来告诉你秋季舒服又贴心的日常减肥技巧，让您做个健康瘦美人。

简介：ElevenRoseMesh网球裙名将大威自创品牌Elever本季主打的印花网球裙在美网赛场令人眼前一亮,相比其他品牌略显单调的设计,这条球裙大胆活泼又不失性感女人味,可惜的是维纳斯只展示了两场就被郑洁击败出局。

简介：列维坦（1860-1900），俄国杰出的写实画家，现实主义风景画大师，巡回展览派的成员之一。列维坦的作品极富诗意，深刻而又真实地表现丁俄罗斯大自然的壮美与变化万千。他的写生画富有独到之处：用笔洗练，情感充沛，沉思内敛中隐含一丝忧郁。

简介：整整一个上午我都无所事事爬爬楼梯或在小区里转悠这是十一我的假期没有超出这个小区金黄花园里的向阳花墨绿铁栅上的爬山虎想想上帝想想马克思

简介：伴着《我和草原有个约定》的音乐声,我自驾车来到了内蒙古乌兰布统草原看秋景.这个埋在心头很久的愿望终于实现了.乌兰布统草原位于内蒙古赤峰市克什克腾旗最南端,与河北省围场县的塞罕坝林场隔河相望.

简介：敏感、多愁、脆弱的里尔克是孤独的，而这孤独时浓时淡、时轻时重，却始终无法消亡。他在颠沛流离的生活中用孤独谱写着美丽的诗歌。用孤独展现了寂寞的美丽。在《秋日》与《豹》中，他那孤独的身影无处不在。

简介：AIM:TodiscusstheimpactofLyciumBarbarumPolysaccharide(LBP)andDanshensupurifiedfromTraditionalChineseMedicine(TCM)onvascularendothelialgrowthfactor(VEGF)ofrabbitswithretinalneovascularization.METHODS:Fortyrabbitsweredividedintonormalcontrolgroup,modelcontrolgroup,LBPgroupandDanshensugroup.Animalsinthenormalcontrolgroupwerefedinthenormaloxygenenvironment.Animalsintheotherthreegroupswereputintotheenvironmentwith70%oxygenfor5daysinordertobuildthemodelofoxygen-inducedvascularproliferationretinopathy.AndthendifferentTCMextractwasinjectedintotheabdominalcavitiesoftheseannimals.After7days,theVEGFcontentofintheserumofrabbitwasmeasuredbydoubleantibodysandwichmethod.RESULTS:DataanalysisindicatedthatVEGFcontentwasasfollows:Danshensugroupwaslowerthanmodelcontrolgroup(12.92±3.84ng/Lvs19.32±4.15ng/L,P<0.05);LBPgroupandnormalcontrolgroupwerelowerthanmodelcontrolgroup(12.92±3.84ng/L,9.26±1.61ng/Lvs19.32±4.15ng/L,P<0.01);totalbloodviscosity,plasmaviscosity,cholesterolcontent,fibrinogencontentandtriacylglycerolcontentafterperitonealinjectionofLBPandDanshensuwereobviouslylowerthanbeforeinjection.CONCLUSION:TCMextract-LBPandDanshensucanprominentlyreducethecontentofVEGFintheprocessofvascularproliferativeretinopathyofrabbit;canpreventtheoccurrenceofretinalmicrovasculardiseasebyimprovingpartialoxygen-deficientenvironmentoraffectingallkindsofnewgrowthfactor.

简介：引子远处的廊柱模模糊糊的，目光无法聚焦在一点。脑袋像被搅拌机搅过一般，混混沌沌，四分五裂。渐渐地，男人注意到自己的手上拿着一样东西，那上面有红色的液体在延淌着。“血……”他的脑中闪过一个可怕的念头，令其浑身都为之一颤。他使劲地揉了揉眼睛，试图再一次将目光聚焦到手上。——那是一把刀，黑色的刀柄就握在他的手上，而短短的刀刃上淌着像血一样的东西。他的手颤抖起来，脑海中闪回式地浮现出了片段的记忆。那个女人一直在叫嚣。她说：“明天，你那副道貌岸然的嘴脸就会被公之于众。”她嘴角飞着唾沫，两只眼角向上吊起，之前看她还觉得娇媚可人，此时此刻却丑态毕露。她又说：“除非你帮我做一件事，我就保证永远闭嘴，绝不再给你惹任何麻烦。”

简介：AIM:ToexploretheinhibitoryeffectofasustainedcyclosporinA(CsA)deliverymicrosphere(CsA-MS)onposteriorcapsularopacification(PCO)inrabbiteyesaftercataractextraction.·METHODS:TwentyNewZealandwhiterabbitsacceptedcataractextractionplusintraocularlensimplantationandtheirlefteyeswereintraoperativelyinjectedCsA-MSpreparedusingpolymerpolylactioglycolicacid(PLGA)asacarrierandtheirrighteyeswereinjectedwithemptyMS.Thechangesincornea,anteriorchamberreaction,intraocularpressure,PCOandCsAconcentrationinaqueoushumorwereexaminedpostoperativelyandalltheeyeswereenucleated3monthsaftersurgeryforhistopathologicalandmorphologicalexaminationwithlightmicroscopyandelectronmicroscopy.·RESULTS:Conjunctivalhyperemia,cornealedema,intraocularpressureandanteriorchamberresponseofexperimentalandcontroleyesweresimilar,whilePCOinCsAMSinjectedeyeswasgreatlyimprovedcomparedwiththatincontroleyes.PosteriorcapsulesinCsA-MSinjectedeyesweresmoothandlensepithelialcells(LEC)didnotproliferatesignificantly(P>0.05),whileLECinposteriorcapsuleofcontroleyeshaddifferentdegreesofproliferationandcorticalregeneration.LECinCsA-MSinjectedeyeswerenotfunctionallyactiveandunderwentapoptosis,whereasLECincontroleyeswerefunctionallyactive(F-test,P=0.025).Inaddition,thecornealultrastructureshowednodifferencesbetweenCsA-MSandMSinjectedeyes.CONCLUSION:CsA-MShashighbioavailabilityinrabbiteyesandcouldinhibitpostoperativePCOoccurrenceanddevelopmentduringthestudyperiod,suggestingthatCsA-MSmaybeapromising,effectiveandsafeadministrationroutetopreventPCOinclinic.

简介：AIM:ToinvestigatetheeffectofY-27632onthesurvivalandneuriteoutgrowthoftheculturedretinalneurocytes.METHODS:Afterthepostnatalday2-3,Sprague-Dawleyretinalneurocyteswereculturedfor48hours,theculturemediawasreplacedwithserum-freemedia(controlgroup)andserum-freemediacontained30μmol/LY-27632(Y-27632group),andthecellswerecontinuallyculturedanother48hours.Theculturedretinalneurocyteswereidentifiedwithanti-neuronspecificenolase(NSE)immunocytochemistry.ThesurvivalstateofthosecellswasestimatedbyMTTassay,andtheneuriteoutgrowthofthosecellswasevaluatedbythecomputerizedimage-analysissystem.RESULTS:Comparedwiththecontrolgroup,theabsorbancevaluesofcellssurvivalinY-27632groupincreased12.90%and33.33%respectivelyafter72and96hoursculture.Y-27632hadnosignificanteffectonthediameterofculturedretinalneurocytes.Comparedwiththecontrolgroup,Y-27632inducedastableimprovementofneuriteoutgrowthofretinalneurocytesafter72and96hoursculture(P=0.001).CONCLUSION:Y-27632couldpromotethesurvivalandneuriteoutgrowthoftheearlypostnatalculturedretinalneurocytes.

简介：AIM:Toevaluatetheepidemiologic,anatomic,andclinicalfeaturesofopenglobeinjuriesinchildren.METHODS:Themedicalfilesofpatientsundertheageof16whohadbeenoperatedforanopenglobeinjuryatAkdenizUniversityHospital’sDepartmentofOphthalmologywereretrospectivelyevaluated.RESULTS:Atotalof90patientswereevaluatedinthisstudy.Amongthesepatients,26(28.9%)werefemaleand64(71.1%)weremale.Themeanageofthepatientswas7.7±4.2years.Themale/femaleratiowasobservedtoincreasewithincreasingage(P=0.006,P=7.48).Injuriesweremostlikelytooccurinspringandautumn(P=0.028).Thetimeintervalbetweentheinjuryandthesurgicalrepairwas9.36±27.4h.Forty(44.4%)oftheinjuriesoccurredinthehome,27(30%)occurredintheyard,and21(23.3%)happenedwhileplayinginthestreet.Themostcommoncausesofinjuryweresharpmetalobjects(P<0.001).Injurytothecorneaoccurredin47(52.2%)ofthepatients(P<0.001).Themostcommoncomplicationtooccurwascataractformation.Additionaloperationswerenecessaryfor37(41.1%)ofthepatients.Thefinalvisualacuitywascorrelatedwithboththeinitialvisualacuityofthewoundedeyepriortosurgeryandthelengthofthewound(P<0.001,r=0.502andP<0.001,r=-0.442,respectively).CONCLUSION:Openglobeinjuriesthataresufferedinchildhoodgenerallyoccureitherathome,intheyard,oronthestreet,withsharpmetalobjectsbeingthemostcommoncauseofinjury.Theinitialvisualacuityandthelengthofthewoundarethemostimportantdeterminantsofthefinalvisualacuity.

简介：AIM:Tocharacterizetemporalpatternofresolutionandrecurrenceofnaivechoroidalneovascularization(CNV)secondarytowetage-relatedmaculardegeneration(AMD)treatedwithintravitrealbevacizumabonasneededregimen,andtoanalyzebaselineriskfactorsforCNVresolutionorrecurrence.METHODS:Ninety-oneeyesof80patientswithnewlydiagnosedwetAMDwereretrospectivelystudied.Alleyesweretreatedwitharoundofthreemonthlyintravitrealbevacizumabinjections,followedbyoneadditional’bonus’injectionafterresolutionofCNVactivity.Duringfollow-up,eyesweremonitoredwithfluoresceinangiography,opticalcoherencetomography,andbest-correctedvisualacuity(BCVA).IncaseofrecurrencesofCNVactivity,eyeswereretreatedwithotherroundsofbevacizumabinjectionsfollowingthesametreatmentprotocol.RESULTS:Overamedianfollow-upof532d,themedianresolutiontimeofCNVactivityinthefirst,second,andthirdtreatmentroundwas98d,126d,and111d,respectively.Themedianrecurrencetimeforthethreeroundswas154d,126d,and151d,respectively.Nosignificantdifferenceinresolutiontime(P=0.09)orinrecurrencetime(P=0.11)wasdetectedamongtreatmentrounds.Age(P=0.0082)andlensstatus(P=0.035)werefoundtobeassociatedwithCNVresolution;forevery1-yearincreaseinagetherewas4%greaterchanceofCNVresolution;Phakiceyesdemonstrateda33%betterchancetoexperienceCNVresolutionthanpseudophakiceyes.ForCNVrecurrence,lensstatus(P=0.0009)andgender(P=0.0446)werefoundtobepredictive;pseudophakiceyeshada3.69-foldgreaterrisktoexperiencerecurrenceofCNVactivitycomparedtophakiceyes;maleshada2.19-foldgreaterrisktoexperiencerecurrenceofCNVactivitythanfemales.NosignificantBCVAchangesamongthreetreatmentroundswerenoted(P=0.56).CONCLUSION:ResolutiontimeandrecurrencetimeofCNVactivitywerenotsignificantlydifferentamongtreatmentrounds,suggestingabsenceoftachyphylaxistobevacizumab.Acautiousdecisionshouldbemadeupondisco

简介：AIM:ToevaluatetheefficacyofSeprafilmtransplantationfollowingadhesiolysisforpreventingpostoperativereadhesionandimprovingsurgicaloutcomes.METHODS:Primaryblepharoplastywascarriedoutonbotheyelidsof18albinorabbits.After2weeks,anewskinincisionwasmade,andadhesiolysiswasperformedonbotheyelids.Therabbitswerecategorizedintotwogroups,onewithadhesiolysisaloneinthelefteyelid(controlgroup),andtheotherwithadhesiolysiswithaSeprafilmgraftintherighteyelid(Seprafilmgroup).Thedegreesofinflammationandfibrosiswereexaminedwithhematoxylin-eosin(HE)andMasson’strichromestains.Expressionofα-smoothmuscleactin(α-SMA)wasalsoimmunohistochemicallyexamined.RESULTS:Eyelidexaminationimmediatelyaftertheoperationrevealedmildswellingandhemorrhageinbothgroups,butthesesymptomsresolvedafter1week-2weeks,andeyelidshapehadrecoveredcompletelyinbothgroups.MicroscopicassessmentsdemonstratedthattheSeprafilmgroupshowedlessinflammationandfibrosisthanthecontrolgroup.TheSeprafilmgroupalsoexhibitedfewerα-SMA-positivecellsthanthecontrolgroup.CONCLUSION:Basedonthesefindings,weconcludethatSeprafilmgraftwithadhesiolysisisaneffectivemethodforpreventingpostoperativereadhesionsaftereyelidsurgery.

简介：AIM:ExcessivedissolveofcornealtissueinducedbyMMPswhichwereactivatedbycytokinsandchemokineswillleadtocornealulcer.ThemolecularmechanismofLipoxinA4(LXA4)oncornealcollagendegradationinthreedimensionswasinvestigated.·METHODS:Rabbitcornealfibroblastswereharvestedandsuspendedinserum-freeMEM.TypeIcollagen,DMEM,collagenreconstitutionbufferandcornealfibroblastsuspensionweremixedonice.Theresultantmixturesolidifiedinanincubator,afterwhichtestreagentsandplasminogenwasoverlaidandthecultureswerereturnedtotheincubator.Thesupernatantsfromcollagengelincubationswerecollectedandtheamountofhydroxyprolineinthehydrolysatewasmeasured.ImmunoblotanalysisofMMP-1,-3andTMMP-1,-2wasperformed.MMP-2,-9wasdetectedbythemethodofGelatinzymography.Cytotoxicityassaywasmeasured.RESULTS:LXA4inhibitedcornealcollagendegradationinadoseandtimemanner.LXA4inhibitedtheIL-1βinducedincreasesinthepro-MMP-1,-2,-3,-9andactiveMMP-1,-2,-3,-9inaconcentrationdependentmanner.LXA4alsoinhibitedtheIL-1βinducedincreasesinTIMP-1,-2.CONCLUSION:Asapotentanti-inflammationreagent,LXA4caninhibitcornealcollagendegradationinducedbyIL-1βincornealfibroblaststhusinhibitingcornealdissolvingpathologyprocess.

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