简介:SmallRNA(sRNA)-mediatedpost-transcriptionalregulationdiffersfromprotein-mediatedregulation.Throughbasepairing,sRNAcanregulatethetargetmRNAinacatalyticorstoichiometricmanner.Sometheoreticalmodelswerebuiltforcomparisonoftheprotein-mediatedandsRNA-mediatedmodesinthesteady-statebehaviorsandnoiseproperties.ManyexperimentsdemonstratedthatasinglesRNAcanregulateseveralmRNAs,whichcausescrosstalkbetweenthetargets.Here,wefocusonsomemodelsinwhichtwotargetmRNAsaresilencedbythesamesRNAtodiscusstheircrosstalkfeatures.Additionally,thesequence-functionrelationshipofsRNAanditsroleinthekineticprocessofbase-pairinghavebeenhighlightedinmodelbuilding.
简介:SmallRNAhasrecentlydrawnmoreandmoreattention.Inthispaper,weconcentrateontheinfluenceofnoisesongenenetworkregulatedbysmallRNAusingchemicalLangevinequation.Itshowsthatthenoisecancauseoscillationwhentheoscillatedoesnotoccurinthecorrespondingdeterministicsystem.Thecoherenceofthenoiseinducedoscillationreachesamaximumforanoptimalintensityofnoise,andthecoherenceresonanceappearsaccordingly.Thefindingsimplyprobablyomnipresentimportanceofnoiseinthefunctioningprocessoflivingorganism.
简介:当弹体表面安装喷管时,在喷管迎风条件下往往出现不利的侧向喷流干扰,翼梢安装喷管能减弱这种不利干扰.采用有限体积离散方法求解N-S方程,研究了旋成体-边条翼-舵组合体翼梢安装喷管的侧向喷流干扰特性和规律.分析了干扰流场结构和喷流干扰因子随Mach数、攻角、飞行高度等参数的变化特性.研究结果表明:翼梢喷流干扰形成了非常复杂的流场结构,虽然翼梢喷流远离弹体,仍对弹体、翼、舵上的载荷产生明显影响,在不同飞行条件下干扰范围和强度明显不同.喷流气动干扰因子规律复杂并呈非线性变化,干扰因子大于0.5的范围明显增加,有效增加了喷流控制使用范围.但在某些条件下仍然出现较大负值,产生严重不利干扰现象.
简介:Recently,RNAprocessinghasemergedasanovelpathwaythatmaycontributetothemaintenanceofgenomestability[1].Alternativesplicingisakeymolecularmechanismforincreasingthefunctionaldiversityoftheeukaryoticproteomes,butitalsooftenalteredincancer.Mountingevidenceindicatesthatalternativesplicing,theprocessthatallowsproductionofmultiplemRNAvariantsfromeachgene,contributestotheheterogeneityofthedisease[2].Althoughthemechanismofalternativesplicingvariantincancerisunclear,thecancer-specificalternativesplicingvariantshavebeenobservedinavarietyofhumancancersandcancercelllinesandhavebeenconnectedtotumorgenesis.
简介:盒式翼布局相对常规布局可以很大程度地减小诱导阻力,同时平滑的升力分布有利于减小跨声速激波阻力,但双翼间的气动干扰是跨声速盒式翼布局存在的主要问题.为掌握跨声速双翼气动干扰特性,选用超临界翼型RAE2822作为双翼翼型,对M=0.75,正负交错两种情况下双翼几何参数对布局升阻特性的影响进行数值研究.结果表明,增大双翼的纵向距离可以减弱双翼间气动干扰,使升阻比提高至无干扰升阻比.其中,前翼在下、后翼在上的负交错布局在双翼纵向距离为1.5倍上翼弦长时即可接近无干扰升阻比,更有利于提升布局的升阻特性.负交错时双翼的垂直间距对布局升阻比影响不大,无翼差角且减小前翼弦长有利于提高升阻比.