简介:Chitosan/,-glycerophosphate(CS/,-GP)当周围的温度增加了时,thermo敏感的hydrogels在低温度和半固体hydrogel介绍了可流动的答案状态。在这研究,metronidazole的不同集中包含了,CS并且,象不同的酸溶剂一样的-GP,,被选择从CS/在药版本行为上评估他们的影响,-GPhydrogels。在一个高原跟随的开始的3h期间有一个支撑的版本,这被发现。SEM图象证明药表面位于并且在hydrogels的内部。为药版本的这hydrogel的最佳的准备条件如下:1.8%(w/v)在HAc溶剂的CS,5.6%(w/v),-GP和5g/Lmetronidazole封装。Cytotoxicity评估没发现有毒的效果。为了控制版本率,有球形的形状的2.5g/Lchitosanmicrospheres和光滑的表面,被合并,并且起始的版本进程被减轻,这被发现,当药集中没在版本率上有明显的效果时。metronidzole版本行为能根据实际应用被优化,这能被结束。
简介:Variousfunctionalgroupshavebeensuggestedtoplayessentialrolesonbiomineralizationofcalciumcarbonate(CaCO3)innaturalsystem.2Dand3DmodelsofregularlyarrangedfunctionalgroupshavebeenestablishedtoinvestigatetheireffectonCaCO3crystallization,Thismini-reviewsummarizestherecentprogressandthefuturedevelopmentisprospected.
简介:Thepurposeofthisresearchistoquantifytheeffectsofcompositionalandprocessingparametersonthemicrostructureandpropertiesofdualphasesteelproduceddirectlybyhotrollingandrapidcooling.Steelswiththebasecompositionof0.1%C,1.4%Si,and1.0%Mnwithadditionsof0.5%Crtoinfluencehardenability,0.04%Nbtoretardrecrystallizationinthelatterstagesofrolling,or0.02%Titoinhibitgraingrowthduringandafterreheatingwereinvestigated.Investigationwasmadetopredictmicrostructureevolutionandtocorrelatemicrostructurewithprocessingparameters.Theeffectsoftheimportantmicrostructureparameterssuchasferritegrainsize,martensitevolumefraction(VM)andmorphology(polygonalorfibrous)onthetensileandimpactpropertiesarediscussed.Multiplelinearregressionanalysisoftheultimatetensilestrengthhasshownthat,increasingVMandmartensitemicrohardnessandgrainrefinementofferritearethemajorcontributionstoincreasethestrengthofthesteel.Itwasfoundthatthedual-phasesteelproducedbycontrolledrollingprocess,withamicrostructurewhichconsistedoffinegrainedferrite(4μm)and35%~40%fibrousmartensite,presentedoptimumtensileandimpactpropertiesbecauseofenhancedresistancetocrackpropagation.
简介:GliomacelllineC6culturedonsiliconsurfacesmodifiedbydifferentchemicalfunctionalgroups,includingmercapto(-SH),carboxyl(-COOH),amino(-NH2),hydroxyl(-OH)andmethyl(-CH3)groups,wasstudiedheretoinvestigatetheinfluenceofsurfacechemistryonthecellproliferation,adhesionandapoptosis.AFMconfirmedthesimilarcharacteristicofdifferentfunctionalgroupsoccupation.TheadheringC6exhibitedmorphologicalchangesinresponsetodifferentchemicalfunctionalgroups.TheC6adheredto-COOH,-NH2,-OHand-CH3surfacesandflattenedmorphology,whilethoseon-SHsurfaceexhibitedthesmallestcontactareawithmostlyroundedmorphology,whichledtothedeathofcancercells.TheresultsofMTTassayshowedthatthe-COOHand-NH2groupspromotedceilproliferation,whilethe-SHsignificantlyinhibitedtheproliferation.Comparedwithotherchemicalfunctionalgroups,the-SHgroupexhibiteditsuniqueeffectonthefateofcancercells,whichmightprovidemeansforthedesignofbiomaterialstopreventandtreatglioma.
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