简介：Objective:Todetecttheinhibitionofurogenitalchlamydiatrachomatis(CT)by12traditionalChinesemedicinesinvitro.Methods:TheinhibitionofCTisolatesbythesemedicineswasdetectedbymicro-culturetechniquewithMcCoycellsinvitro.Results:AllthediuretictraditionalChinesemedicinesinhibitedurogenitalCT.Theminimuminhibitoryconcentrations(MICs)rangedfrom0.122mgml^-1to62.5mgml^-1.DiathussuperbusL.,Poriacocos(Shcw.)Woft,Polyporusumbellatus(Pers.)Fries,andArtemisiacapillariesThunbshowedstrongerinhibitionthantheothereighttraditionalChinesemedicines.Thenumbersandsizesofinclusionsbodiesreducedgraduallyanddisappearedfinallywiththeincreaseoftheconcentrations.Conclusion:Allthe12diuretictraditionalChinesemedicinesinhibitedurogenitalCT.

简介：Objective:TostudytheeffectoftraditionalChinesemedicineantiviralcapsulesinthetreatmentofgenitalherpes.Methods:Usingfemaleguineapiggenitalherpesastheanimalmodel,thisstudyusedoraladministrationoftwoformulationsofantiviralcapsules(AC)andobservedtheeffectonvaginalHSV-2titersandvulvarsymptoms.CellcultureswerealsousedtoexaminethedirectinactivationofHSV-2bytheantiviralcapsulesandthesuppressionofHSV-2viathreedrugadministrationmethods.Results:Therewasnosignificantdifferenceofmeanvaginalvirustitersbetweentheantiviralcapsulegroupsandthatofthepositiveacyclovir(ACV)control(P>0.05).Meanvulvarsymptomscoresofthetwoantiviralcapsulegroupswerealsosignificantlylowerthanthatofthesalinenegativecontrolgroupondays2,3,5,7and8(P<0.05)andsimilartothatoftheACVcontrol(P>0.05).CellcultureshowedtheminimuminhibitoryconcentrationsofantiviralcapsulesNo.1andNo.2were0.390625mg/mland1.5625mg/ml,respectively.Conclusion:ThetraditionalChinesemedicineantiviralcapsuleshadsuppressiveeffectsonHSV-2inbothanimalmodelGHandinvitrocellculture.