简介：Agiantcelltumoroccursmainlyintheproximaltibia,humerus,distalradiusboneandthepelvicbone.Itisrarelyobservedinsuchsitesastheribsandthetemporalbone.Theconditionisprimarilytreatedwithsurgicalexcisionandfunctionalreconstruction.Theeffectofchemotherapyonlungmetastasesandlocallyadvancedgiantcelltumorshasremainedunknown.Wecollectedandanalyzedthedataofsixpatientswithraregiantcelltumorslocatedintheheadandneckpatients.Afteranaveragefollow-upof42.6monthsaftersurgery(14to90months),nolocalrecurrenceormetastasiswasobserved.Wealsocollectedandanalyzedthedataoffivepatientswithmetastaticgiantcelltumorswhowereundergoingsurgeryfortheprimarytumorbefore;ofthreepatientswhohadexperiencedmultiplechemotherapycycles,onehadspontaneousregression,andonesurvivedforlongtimerdespiteprogression.Theothertwopatientshadtheirmajormetastaticlesionsresectedbysurgery,andpresentedlong-termsurvivalduringthefollowup.Inaddition,thisstudyreportsonepatientwithlocallyadvancedgiantcelltumoroftherib,whohasundergonesuccessfulsurgicalresectionfollowingtwocyclesofchemotherapywithifosfamideandliposomaldoxorubicin.Completeresectionofthelesionattheheadandneckisthekeytorelapse-freesurvival.Theprognosisoflungmetastasesinpatientswithgiantcelltumorsisrelativelysatisfying.Neoadjuvantchemotherapyisalsoconducivetothesurgeryforlocallyadvancedlesionsandimprovementofthequalityoflife.

简介：客观：与非小的肺癌症(NSCLC)在病人的预后上在MRP基因overexpression的效果上学习。方法：从NSCLC的47个盒子的嵌入石蜡的纸巾经历了激进的肿瘤切除术的人，用探针与immunohistochemistry相结合的标记的digoxigenin为MRP基因mRNAbyinsitu杂交的表示被检查。所有病人是回顾地跟随起来的。结果：47个肺癌症标本的AU被发现有MRP基因mRNA的overexpression。它显著地在外科以后与病人鈥?幸存时间，对化疗的反应，复发或转移被相关，但是没与组织学，肿瘤尺寸，节点地位，TNM阶段，区别的度，年龄和性别被相关。结论：MRP基因的Overexpression是在有NSCLC的病人的预示的意义的一个标记。