简介：目的将在hepatocellular癌(HCC)调查cortactin表示并且在HCC病人的预后探索它的意义。方法Immunohistochemistry被执行让119HCC纸巾(HCC)和paratumorous肝纸巾(PTLT)的石蜡样品计算cortactin表达式。在HCC和PTLT的cortactin表示差别被McNemars测试分析。在HCC和clinicopathologic因素的cortactin表情的关系与Mann-WhitneyU测试被分析。Kaplan-Meier方法和木头等级测试被采用比较在Cortactin否定表示组，弱表示组和强壮的表示组之间的全面幸存。cortactin的表示进一步与西方的弄污在19个新鲜HCC和PTLT标本被决定。结果Cortactin表示率在HCC是显著地更高的(53/119，44.5%)比那在PTLT(2/119，1.7%)(P<0.001)。在HCC的upregulatedcortactin表示显著地被相关到形成(P=0.012)，脉管的侵略(P=0.037)和高Edmondson啤酒杯杯分级的囊的缺席(P=0.020)，并且预言了更短的全面幸存。西方的弄污证明那cortactin表情与相应PTLT相比从19HCC(47.4%)是在9的upregulated。结论Cortactin表示是在HCC的upregulated并且与病人的更短的全面幸存有关，建议cortactin可能起在HCC的转移的作用并且预言HCC病人的差的预后。

简介：Objective:TheexpressionofB-celllymphoma2(Bcl-2)seemstobeinfluencedbytheendocrineenvironment.NumerousreportsdemonstratethediverseexpressionofBcl-2familymembersundersexsteroidregulation.Withtheexceptionofestrogen-relatedtumors,androgen-relatedtumorshaveshowntheircharacteristicsinBcl-2expression.Inthisstudy,thestatusofBcl-2expressioninmalehepatocellularcarcinoma(HCC)patientswasexaminedtoverifythehighincidenceofHCCinmales.Methods:TumortissuemicroarraywasusedtoexamineBcl-2expressionlevelsin374HCCcasesincluding306malesand68females.Kaplan-Meiermethod,log-ranktest,andCoxproportionalhazardsmodelwereappliedtoinvestigatethepredictivevalueofBcl-2inHCCpatients.Results:ImmunohistochemistryanalysisshowedthatmalepatientswithhigherBcl-2levelshadsignificantlylongermediansurvivaltimeandrecurrencetimethanthosewithlowerlevels.However,nosignificantdifferencesinoutcomeswerefoundbetweendifferentBcl-2levelsinfemalepatients.Whenthemalepatientswerestratifiedintoseveralagepoints,thelevelofBcl-2expressionshowedpoorerpredictiveefficiencyinthe45–49and55–60agegroupsinandropause-agepatientscomparedwithotheragegroups.Bcl-2wasanindependentprognosticfactorforbothoverallsurvival(P<0.0001)andrecurrencetime(P=0.0001)inmalepatients.Afterexcludingmalepatientsinthe45–60agegroup,thepredictiveefficiencywasenhanced(n=147,OS,P=0.0002,TTR,P<0.0001).Conclusions:Bcl-2expressionisanindependentpredictorofsurvivalandrecurrenceinmaleHCC.Bcl-2levelsmayalsoberegulatedbyandrogensorandrogenreceptorsinmaleHCCpatients.Bcl-2levelschangeandexhibitpoorpredictiveefficiencywhenandrogenlevelsvarydramatically(andropauseage).

简介：Objective:Mucoepidermoidcarcinoma(MEC)isthemostcommonprimarymalignancyofthesalivaryglands.Insulin-likegrowthfactor-IImRNA-bindingprotein-3(IMP3)isanimportantprognosticfactorinsomecancersandatoolthatdifferentiatesbetweenbenignandmalignantpancreaticlesions.ThisstudyaimedtoidentifyarelationshipbetweentheexpressionofIMP3andtheoutcomeofsalivaryglandMEC,aswellastodifferentiateMECfrompleomorphicadenoma(PA).Methods:Tissuespecimensfrom70casesofsalivaryglandMEC,40casesofPA,and10caseswithnormalsalivaryglandwereexaminedimmunohistochemicallyforIMP3.TheassociationamongtheexpressionofIMP3,clinicopathologicalcharacteristicsandpatient'ssurvivalwasassessed.Results:IMP3waspresentin51.4%ofMECbutabsentinPAandnormalsalivaryglandtissues.IMP3expressionwasassociatedwithage>60years,submandibularglandtumors,tumorsize>4cm,high-gradetumors,lymphnodemetastasis,involvementofsurgicalmargins,perineuralinvasion,distantmetastasis,advancedTNMstage,tumorrelapse,anddeath(P<0.05).IncreasedexpressionofIMP3,tumorsofthesubmandibulargland,andlymphnodemetastasiswereindependentprognosticfactorsofdisease-freesurvival(DFS).Inaddition,IMP3wasastrongpredictorofoverallsurvival(OS)togetherwithdistantmetastasisandintermediateandhigh-gradetumors.Conclusions:IMP3expressionishighlyimportantinevaluatingtheoutcomeofMEC.IMP3canbeusedtodifferentiateMECfromPAofsalivaryglands.