简介：Objective:Population-basedcancerregistrationdatawereusedtoanalyzetheepidemiologyandtrendofmalignantmesotheliomainChina,andtheresultwouldprovidebasicdataforitspreventionandcontrol.Methods:Malignantmesotheliomadatain2013wereretrievedfromthedatabaseofNationalCancerRegistry.Malignantmesotheliomaincidenceandmortalitywereestimatedusingage-specificratebyurban/ruralandgenderaccordingtothenationalpopulationin2013.Malignantmesotheliomadatafrom22cancerregistrieswereusedfortrendanalysisduring2000–2013.Results:Itisestimatedthattherewere2,041newmalignantmesotheliomacasesand1,659malignantmesotheliomadeathsoccurredin2013.ThecrudeincidencerateinChinawere1.50/106(males1.67/106,females1.32/106),age-standardizedincidenceratesbyChinesestandardpopulation(ASIRC)andbyworldstandardpopulation(ASIRW)were1.03/106and1.02/106,respectively.ThecrudemortalityrateinChinawas1.22/106(males1.67/106,females1.32/106),age-standardizedmortalityratesbyChinesestandardpopulation(ASMRC)andbyworldstandardpopulation(ASMRW)were0.83/106and0.81/106,respectively.TherewasanincreasingtrendofincidencerateformalignantmesotheliomainregistrationareasofChinaduring2000–2013withannualpercentagechange(APC)of2.5%[95%confidenceinterval(95%CI):0.6%–4.5%].Afteragestandardization,nosignificantdifferenceswereobserved.Nomatterforcrudemortalityratesorage-standardizedmortalityrates,nosignificantdifferenceswereobservedduring2000–2013.Conclusions:Malignantmesotheliomaisthemajoroccupationalandenvironmentalneoplasmassociatedwithasbestosexposure.Theincreasingincidencetrendsuggeststhatmoreattentionshouldbepaidonthisdisease.

简介：Objective:Population-basedcancerregistrationdatain2010werecollected,evaluatedandanalyzedbytheNationalCentralCancerRegistry(NCCR)ofChina.Cancerincidentnewcasesandcancerdeathswereestimated.Methods:Therewere219cancerregistriessubmittedcancerincidenceanddeathdatain2010.AlldatawerecheckedandevaluatedonbasisofthecriteriaofdataqualityfromNCCR.Total145registries’datawerequalifiedandacceptedforcancerstatisticsin2010.Pooleddatawerestratifiedbyurban/rural,area,sex,agegroupandcancersite.Cancerincidentcasesanddeathswereestimatedusingage-specificratesandnationalpopulation.Thetoptencommoncancersindifferentgroups,proportionandcumulativeratewerealsocalculated.Chinesecensusin2000andSegi’spopulationwereusedforage-standardizedincidence/mortalityrates.Results:All145cancerregistries(63inurbanand82inrural)coveredatotalof158,403,248population(92,433,739inurbanand65,969,509inruralareas).Theestimatesofnewcancerincidentcasesandcancerdeathswere3,093,039and1,956,622in2010,respectively.Themorphologyverifiedcases(MV%)accountedfor67.11%and2.99%ofincidentcaseswereidentifiedthroughdeathcertificationsonly(DCO%)withmortalitytoincidenceratio(M/I)of0.61.Thecrudeincidenceratewas235.23/100,000(268.65/100,000inmales,200.21/100,000infemales),age-standardizedincidenceratesbyChinesestandardpopulation(ASIRC,2000)andbyworldstandardpopulation(ASIRW)were184.58/100,000and181.49/100,000withthecumulativeincidencerate(0-74yearsold)of21.11%.ThecancerincidenceandASIRCwere256.41/100,000and187.53/100,000inurbanareaswhereasinruralareas,theywere213.71/100,000and181.10/100,000,respectively.ThecrudecancermortalityinChinawas148.81/100,000(186.37/100,000inmalesand109.42/100,000infemales),age-standardizedincidenceratesbyChinesestandardpopulation(ASMRC,2000)andbyworldstandardpopulation(ASMRW)were113.92/100,000and112.86/100,0

简介：Follicularlymphoma(FL)isacommonsubtypeofB-celllymphoma.BasedontheupdatedNationalComprehensiveCancerNetworkguidelinesandrelatedmedicaldata,theauthorsformulatedtheFLguidelinesforChinabycombiningthediagnosticlevelandcurrentsituationoflymphoma.

简介：Objective:ToanalyzetheincidenceandmortalityratesoflungcancerinChinafrom2008to2012.Methods:IncidentanddeathcasesoflungcancerwereretrievedfromtheNationalCentralCancerRegistry(NCCR)databasecollectingfrom135cancerregistriesinChinaduring2008-2012.Thecrudeincidenceandmortalityratesoflungcancerwerecalculatedbyarea(urban/rural),region(eastern,middle,western),genderandagegroup(0,1-4,5-9,…,85+).Chinacensusin2000andSegi’sworldpopulationwereappliedforagestandardizedrates.JoinPoint(Version4.5.0.1)modelwasusedfortimetrendanalysis.Results:Thecrudeincidencerateoflungcancerwas54.66/100,000whichrankedthefirstinoverallcancers.Theage-standardizedincidenceratesbyChinapopulation(ASIRC)andbyWorldpopulation(ASIRW)were35.13/100,000and34.86/100,000,respectively.ThecrudemortalityoflungcancerinChinawas45.60/100,000anditwasthefirstcauseofcancer-relateddeathinoverallcancers.Theage-standardizedmortalityratesbyChinesestandardpopulation(ASMRC)andbyworldstandardpopulation(ASMRW)were28.57/100,000and28.22/100,000,respectively.Incidenceandmortalityratesoflungcancerwerehigherinmalesthaninfemalesandhigherinurbanareasthaninruralareas.Easternareashadthehighestincidenceandmortalityratesfollowedbymiddleandwesternareas.Incidenceandmortalityratesoflungcancerretainedlowlevelinagegroupsbefore40yearsoldbutincreasedgreatlyafterandpeakedinagegroupof80-84.During2003-2012,thetemporaltrendoftheincidencerateoflungcancerinbothsexesinChinawasgeneralstable(P<0.05).Thelungcancerincidencerateincreasedby0.71%peryearinfemales(P<0.05)and2.26%peryearinruralareas(P<0.05).Themortalityrateoflungcancerdecreasedslightlyannuallyduring2003-2012inChina(P>0.05).Inurbanareas,itdeclinedby0.76%peryear(P<0.05),butroseby2.09%peryear(P<0.05)inruralareas.Conclusions:Appropriatetargetedprevention,earlydetectionandtreatment

简介：Esophagealcancerisoneofthemostfataldiseasesworldwidemainlybecauseofitsrapidprogressionandpoorprognosis.AlthoughtheincidenceofesophagealadenocarcinomahasmarkedlyriseninNorthAmericaandEuropeinthepastseveraldecades,esophagealsquamouscellcarcinomaisstillthepredominantsubtypeofesophagealcancer,especiallyinChina.Itaccountsformorethan90%ofallesophagealsquamouscellcarcinomacasesinChina.Geographicaldifferentiationisoneofthemostdistinctivecharacteristicsofesophagealcancer.Theprogression,riskfactors,andprognosisofthesetwosubtypesofesophagealcancerdiffer.Thisstudyreviewstheepidemiology,etiology,andpreventionofesophagealsquamouscellcarcinomainChina,therebyprovidingsystematicreferencesforpolicy-makerswhowilldecideonissuesofesophagealcancerpreventionandcontrol.

简介：Objective:LivercancerisoneofthemostcommoncancersandmajorcauseofcancerdeathsinChina,whichaccountsforover50%ofnewcasesanddeathsworldwide.Thesystematiclivercancerstatisticsincludingofprojectionthrough2030couldprovidevaluableinformationforpreventionandcontrolstrategiesinChina,andexperienceforothercountries.Methods:TheburdenoflivercancerinChinain2014wasestimatedusing339cancerregistries’dataselectedfromChineseNationalCancerCenter(NCC).Incidentcasesof22cancerregistrieswereappliedfortemporaltrendsfrom2000to2014.Theburdenoflivercancerthrough2030wasprojectedusingage-period-cohortmodel.Results:About364,800newcasesoflivercancer(268,900malesand95,900females)occurredinChina,andabout318,800livercancerdeaths(233,500malesand85,300females)in2014.WesternregionsofChinahadthehighestincidenceandmortalityrates.Incidenceandmortalityratesdecreasedbyabout2.3%and2.6%peryearduringtheperiodof2000-2014,respectively,andwoulddecreasebymorethan44%between2014and2030inChina.Theyounggeneration,particularlyforthoseagedunder40years,showedafasterdowntrend.Conclusions:Basedontheanalysis,incidenceandmortalityratesoflivercancerareexpectedtodecreasethrough2030,buttheburdenoflivercancerisstillseriousinChina,especiallyinruralandwesternareas.MostcasesoflivercancerinChinacanbepreventedthroughvaccinationandmorepreventioneffortsshouldbefocusedonhighriskgroups.

简介：Objective:Thisstudyaimstoinvestigatethetruth-tellingstatusandtherelevantfactorsofesophagealsquamouscellcarcinoma(ESCC)patientsinHenan,China.Methods:Across-sectionalstudyfromApriltoJune2015usingquestionnaireswasgivento301familymembersofhospitalizedESCCpatientsbasedinthreeaffiliatedhospitalsofZhengzhouUniversity(i.e.,TheFirstHospital,TheSecondHospital,andTumorHospital)andAnyangTumorHospital.Results:Amongthe41.9%(126/301)hospitalizedESCCpatientswhoknewoftheirtruediagnoses,only4.0%patientswereinformedbytheircorrespondingresponsibledoctors,39.7%bytheirfamilymembers,and56.3%bythemselves.UnivariateanalysesshowedthatdisclosureofconfirmedESCCdiagnosistopatientswascorrelatedwithgender,familyhistoryofcancer(FHC),educationlevel,vocation,hospitaladministrativelevel,andattitudesoffamilymembers(P<0.05).Furthermore,multivariateanalysisindicatedthatattitudeoffamilymemberswasthemostimportantandanindependentfactorfordiagnosisdisclosure.ThosepatientswithanegativeFHC,under-education,manualoccupation,advancedstages,andhospitalizedinmunicipalhospitalsexhibitedalowrateoftruthtelling.Conclusions:TruthtellingforESCCpatientsinHenanisnotprevalentandmaybeimprovedthroughconsultationwithfamilymembers,particularlyforpatientswithanegativeFHC,pooreducation,manualoccupation,andadvancedstages.

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简介：Objective:Toevaluatetheefficacyandfeasibilityofscreeningprocedureforuppergastrointestinalcancerinbothhigh-riskandnon-high-riskareasinChina.Setting:Sevencities/counties,representingthreeeconomical-geographicalregions(Eastern,CentralandWestern)inChina,wereselectedasscreeningcenters:threeinhigh-riskareasandfourinnon-high-riskareas.Participants:Villages/communitiesinthesesevencentersregardedasclusterswererandomlyassignedtoeitherinterventiongroup(screeningbyendoscopicexamination)orcontrolgroup(withnormalcommunitycare)ina1:1ratiostratifiedbyeachcenter.Eligibleparticipantsarelocalresidentsaged40–69yearsintheselectedvillages/communitieswithnohistoryofcancerorendoscopicexaminationinthelatest3yearswhoarementallyandphysicallycompetent.Thosewhoarenotwillingtotakeendoscopicexaminationorareunwillingtosigntheconsentformareexcludedfromthestudy.Totally140,000participantswillbeenrolled.Interventions:Inhigh-riskareasofuppergastrointestinalcancer,allsubjectsinscreeninggroupwillbescreenedbyendoscopy.Innon-high-riskareas,30%ofthesubjectsinscreeninggroup,identifiedthroughasurvey,willbescreenedbyendoscopy.Primaryandsecondaryoutcomemeasures:Theprimaryoutcomeisthemortalitycausedbyuppergastrointestinalcancer.Thesecondaryoutcomesincludedetectionrate,incidencerate,survivalrate,andclinicalstagedistribution.Additionaldataonqualityoflifeandcost-effectivenesswillalsobecollectedtoanswerimportantquestionsregardingscreeningeffects.Conclusions:ScreeningstrategyevaluatedinthoseareaswithpositivefindingsmaybepromotednationallyandappliedtothemajorityofChinesepeople.Ontheotherhand,negativefindingswillprovidescientificevidenceforabandoningatestandshiftingresourceselsewhere.Trialregistration:ThestudyhasbeenregisteredwiththeProtocolRegistrationSysteminChineseClinicalTrialRegistry.

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简介：Objective:Thisretrospectivestudyexaminedriskfactorsforcytomegalovirus(CMV)infectionafterumbilicalcordbloodtransplantation(UCBT)andtheimpactofCMVinfectiononpatientsurvival.Methods:Inall176patients,plasmaCMVDNAwasnegativepriortothetransplantation,andexaminedtwiceaweekfor100d,andthenonceweeklyforadditional300d.Preemptiveantiviraltherapy(ganciclovirorfoscarnet)wasstartedinpatientswith>1,000/mLcopiesofCMVDNAbutnofull-blownCMVdisease,andwasdiscontinuedupontwoconsecutivenegativereportsofbloodCMVDNAtest.ThesurvivalandriskfactorsforCMVinfectionordiseasewereexaminedusinglogisticregression.Results:CMVinfectiondevelopedin71%(125/176)ofthepatients,withamedianonsetof32d.Fourpatients(2.3%)developedCMVdisease.Neitherthe5-yearoverallsurvival(OS)norevent-freesurvival(EFS)differedsignificantlyininfectedpatientsvs.thosewithnoinfection(59.4%vs.64.8%,P=0.194;53.4%vs.59.1%,P=0.226).AstepwisemultivariateanalysisindicatedanassociationofCMVinfectionwithage,high-doseglucocorticoids,thenumberoftransplantedCD34+cells,andthenumberofplatelettransfusion,butnotwithgender,theconditioningregimen,andthedayofneutrophilrecoveryandchronicgraft-versushostdisease(cGVHD).Conclusions:CMVinfectionisverycommonafterUCBT,butdoesnotseemtoaffectlong-termsurvivalwithpreemptiveantiviraltreatment.

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简介：Objective:ToevaluatethefeasibilityofDNAimagecytometry(DNA-ICM)asaprimaryscreeningmethodforesophagealsquamouscellcancer(ESCC).Methods:Atotalof5,382localresidentsaged40–69yearsfromthreehigh-riskareasinChina(LinzhouinHenanprovince,FeichenginShandongprovinceandCixianinHebeiprovince)from2008to2011wererecruitedinthispopulation-basedscreeningstudy.And2,526subjectsdeclinedtoreceiveendoscopicbiopsyexaminationwithLugol'siodinestaining,while9and815subjectswereexcludedfromliquid-basedcytologyandDNA-ICMtestrespectivelyduetoslidequality.Finally,2,856,5,373and4,567subjectswereenrolledintheanalysisforendoscopicbiopsyexamination,liquid-basedcytologyandDNA-ICMtest,respectively.Sensitivity(SE),specificity(SP),negativepredictivevalues(NPV)andpositivepredictivevalues(PPV)aswellastheir95%confidenceintervals(95%CI)forDNA-ICM,liquid-basedcytologyandthecombinationofthetwomethodswerecalculated.Receiveroperatingcharacteristic(ROC)curveswereappliedtodeterminethecutoffpointofDNA-ICMforesophagealcancer.Results:DNA-ICMresultsweresignificantlycorrelativewithesophagealcancerandprecancerlesions(χ~2=18.016,P<0.001).Thecutoffpointswere5,802,5,803and8,002basedondissimilarpathologicaltypesoflowgradeintraepithelialneoplasia(LGIN),highgradeintraepithelialneoplasia(HGIN),andESCC,respectively,and5,803waschoseninthisstudyconsideringtheSEandSP.TheSE,SP,PPV,NPVofDNA-ICMtest(cutoffpoint5,803)combinedwithliquid-basedcytology[thresholdatypicalsquamouscellsofundeterminedsignificance(ASCUS)]wereseparately72.1%(95%CI:70.3%-73.9%),43.3%(95%CI:41.3%-45.3%),22.8%(95%CI:21.1%-24.5%)and87.0%(95%CI:85.7%-88.3%)forLGIN,85.7%(95%CI:84.3%-87.1%),41.3%(95%CI:39.3%-43.3%),4.6%(95%CI:3.8%-5.4%)and98.9%(95%CI:98.5%-99.3%)forHGIN,and96.0%(95%CI:95.2%-96.8%),40.8%(95%CI:38.8%-42.8%),1.7%(95%CI:1.2%-2.2%)and99.9%