简介:Personalizedcancermedicinehasseensignificantimprovementsoverthepastdecade.RecentElsevierconference:Miamiwintersymposium2015(MWS2015)'TowardsPersonalizedCancerMedicine'meetingwasdedicatedtothisexcitingfield,andfocusedonnewprogressinpersonalizeddrugdevelopmentandantibodydrugagainstcheckpointpathway.Thismeetingreportsummarizesthekeydevelopmentspresentedanddiscussedatthemeeting,withafocusonimmunotherapy,especiallyontheCTLA-4andPD-1/PD-L1pathways.Themonoclonalantibodydrugsinterveningthesecheckpointpathwayshavethepotentialtoplayalargerroleinpersonalizemedicinewithinthenearfuture.Hereweintendedtoprovideacomprehensivesummaryaboutongoingtrendsandfutureperspectivesonpersonalizedmedicineincancertherapy.
简介:Objective:ToinvestigatetherelationshipbetweenNAD(P)H:quinoneoxidoreductase1(NQO1)C609TpolymorphismandcoloncancerriskinfarmersfromwesternregionofInnerMongolia.Methods:Polymerasechainreaction-restrictionfragmentlengthpolymorphism(PCR-RFLP)wasperformedtoanalyzeNQO1C609Tpolymorphismfrom160healthycontrolsand76coloncancerpatients.Results:Amongthecoloncancerpatients,theincidenceofNQO1Tallele(53.29%)wassignificantlyhigherthanitincontrolgroup(33.75%,P<0.001).TheindividualswithNQO1Tallelehadhigherrisk[2.239(95%CI:1.510-3.321)times]todevelopcoloncancerthanindividualswithNQO1Callele.TheincidenceofNQO1(T/T)(34.21%)incoloncancerpatientswashigherthanthatincontrolgroup(15.62%,P<0.001).Oddsratios(OR)analysissuggestedthatNQO1(T/T)andNQO1(T/C)genotypecarriershad3.813(95%CI:1.836-7.920)timesand2.080(1.026-4.219)timesriskcomparedwithwild-typeNQO1(C/C)genecarriersindevelopingcoloncancer.IndividualswithNQO1(T/T)genotypehad2.541(95%CI:0.990-6.552)times,3.713(95%CI:1.542-8.935)times,and3.471(95%CI:1.356-8.886)timesriskthanindividualswithNQO1(T/C)orNQO1(C/C)genotypeinwelldifferentiated,moderately-differentiated,andpoorly-differentiatedcoloncancerpatients,respectively.Conclusions:NQO1geneC609TcouldbeoneofriskfactorsofcoloncancerinfarmersfromwesternregionofInnerMongolia.
简介:1.期刊文献著录格式为:[序号]作者1,作者2,作者3,等.文题.刊名,年,卷(期):起页码-止页码.[例1]赵凤朝,李子荣,王佰亮,等.骨髓水肿与股骨头塌陷及疼痛的相关性研究.中华骨科杂志,2008,28(8):645-648.[例2]KimYL,ShinSI,NamKW,etal.TotalhiparthroplastyforBilaterallyankylosedhips.JArthroplasty,2007,22(7):1037-1041.2.专著文献的著录格式为:[序号]章节作者.章节名//全书主编者.书名.版次.出版地:出版社.出版:起止页码.
简介:1.期刊文献著录格式为:[序号]作者1,作者2,作者3,等.文题[J].刊名,年,卷(期):起页码-止页码.[例1]赵凤朝,李子荣,王佰亮,等.骨髓水肿与股骨头塌陷及疼痛的相关性研究[J].中华骨科杂志,2008,28(8):645-648.[例2]KimYL,ShinSI,NamKW,etal.TotalhiparthroplastyforBilaterallyankylosedhips[J].JArthroplasty,2007,22(7):1037-1041.2.专著文献的著录格式为:[序号]章节作者.章节名//全书主编者.书名[M].版次.出版地:出版社.出版年:起页码-止页码.
简介:1.期刊文献著录格式为:[序号]作者1,作者2,作者3,等.文题.刊名,年,卷(期):起页码-止页码.[例1]赵凤朝,李子荣,王佰亮,等.骨髓水肿与股骨头塌陷及疼痛的相关性研究.中华骨科杂志,2008,28(8):645-648.[例2]KimYL,ShinSI,NamKW,etal.TotalhiparthroplastyforBilaterallyankylosedhips.JArthroplasty,2007,22(7):1037-1041.2.专著文献的著录格式为:[序号]章节作者.章节名//全书主编者.书名.版次.出版地:出版社.出版:起止页码.
简介:1.期刊文献著录格式为:[序号]作者1,作者2,作者3,等.文题.刊名,年,卷(期):起页码-止页码.[例1]赵凤朝,李子荣,王佰亮,等.骨髓水肿与股骨头塌陷及疼痛的相关性研究.中华骨科杂志,2008,28(8):645-648.[例2]KimYL,ShinSI,NamKW,etal.TotalhiparthroplastyforBilaterallyankylosedhips.JArthroplasty,2007,22(7):1037-1041.2.专著文献的著录格式为:[序号]章节作者.章节名//全书主编者.书名.版次.
简介:1.期刊文献著录格式为:[序号]作者1,作者2,作者3,等.文题[J].刊名,年,卷(期):起页码-止页码.[例1]赵凤朝,李子荣,王佰亮,等.骨髓水肿与股骨头塌陷及疼痛的相关性研究[J].中华骨科杂志,2008,28(8):645-648.[例2]KimYL,ShinSI,NamKW,etal.TotalhiparthroplastyforBilaterallyankylosedhips[J].JArthroplasty,2007,22(7):1037-1041.2.专著文献的著录格式为:[序号]章节作者.章节名//全书主编者.书名[M].版次.出版地:出版社.出版年:起页码-止页码.
简介:1.期刊文献著录格式为:[序号]作者1,作者2,作者3,等.文题[J].刊名,年,卷(期):起页码-止页码.[例1]赵凤朝,李子荣,王佰亮,等.骨髓水肿与股骨头塌陷及疼痛的相关性研究[J].中华骨科杂志,2008,28(8):645-648.[例2]KimYL,ShinSI,NamKW,etal.TotalhiparthroplastyforBilaterallyankylosedhips[J].JArthroplasty,2007,22(7):1037-1041.2.专著文献的著录格式为:[序号]章节作者.章节名//全书主编者.书名[M].版次.出版地:出版社.出版年:起页码-止页码.