简介：AIMtotestthefeasibilityandperformanceofanoveluppergastrointestinal(GI)capsuleendoscopeusinganurse-ledprotocol.METHODSWeconductedaprospectivecohortanalysisofpatientswhodeclinedgastroscopy(oesophagogastroduodenoscopy,OGD)butwhoconsentedtoupperGIcapsuleendoscopy.PatientsswallowedtheupperGIcapsulefollowingingestionof1literofwater(containingsimethicone).AseriesofpositionalchangeswereusedtoexploittheeffectsofwaterflowandmovetheupperGIcapsulefromonegravity-dependentareatoanotherusinganurse-ledprotocol.Capsuletransittime,videoreadingtime,mucosalvisualisation,pathologydetectionandpatienttolerancewasevaluated.RESULTSFiftypatientswereincludedinthestudy.Themeancapsuletransittimesintheoesophagusandstomachwere28sand68minrespectively.Visualisationofthefollowingmajoranatomicallandmarkswasachieved(graded1-5:Poortoexcellent):Oesophagus,4.8(±0.5);gastro-oesophagealjunction(GOJ),4.8(±0.8);cardia,4.8(±0.8);fundus,3.8(±1.2);body,4.5(±1);antrum,4.5(±1);pylorus,4.7(±0.8);duodenalbulb,4.7(±0.7);secondpartoftheduodenum(D2),4.7(±1).TheupperGIcapsulereachedD2in64%ofpatients.Themeanvideoreadingtimewas48minwithstandardplaybackmodeand20minusingQuickview(p=0.0001).NopathologywasmissedusingQuickview.Proceduraltolerancewasexcellent.NocomplicationswereseenwiththeupperGIcapsule.CONCLUSIONTheupperGIcapsuleachievedexcellentviewsoftheupperGItract.FuturestudiesshouldcomparethediagnosticaccuracybetweenupperGIcapsuleandOGD.