简介:BackgroundRightbundlebranchblock(RBBB)maypresentasslurredornotchedSwaveinleadV1.However,slurredornotchedSwavemayalsorepresentslowconductioninthemyocardium.MethodsWeretrospectivelyanalyzedtheQRSpatternsinleadsV3RtoV5Rin7patientswithaslurredornotchedSwaveinleadV1.ResultsIntheleadsV3RtoV5R,6patientsshowedincompleteorcompleteRBBBand1patientslurredornotchedSwave.ConclusionsInthemajorityofECGsinasmallpatientserieswithslurredornotchedSwaveinleadV1,QRSmorphologyindicatingincompleteorcompleteRBBBwaspresentinleadsV3RtoV5R.AfindingoffragmentedQRSintheseleadsmayindicateslowconductioninthemyocardium.
简介:目的探讨激动β3肾上腺素受体(β3-AR)对载脂蛋白E基因敲除(apoE-/-)老年高脂小鼠肺脏血管紧张素受体(ATR)表达的影响。方法野生型C57BL/6J小鼠10只作为对照组,apoE-/-老年高脂小鼠40只随机分为高脂模型组、β3-AR激动剂小剂量组(小剂量组)、β3-AR激动剂大剂量组(大剂量组)和β3-AR拮抗剂组(拮抗剂组),每组10只。给予高脂饮食饲养至36周龄后分别给予药物干预12周。采用全自动生化分析仪检测TC和VLDL/LDL-C水平,实时定量PCR或Westernblot测定肺组织β3-AR、AT1R和AT2R的mRNA及蛋白表达水平。结果与高脂模型组比较,小剂量组、大剂量组TC和VLDL/LDL-C水平明显降低[(18.27±1.30)mmol/L,(17.06±1.50)mmol/Lvs(22.20±1.29)mmol/L和(14.31±0.31)mmol/L,(12.78±0.55)mmol/Lvs(19.41±0.40)mmol/L,P〈0.01]。与对照组比较,高脂模型组和拮抗剂组AT1RmRNA和AT1R蛋白水平明显升高,AT2RmRNA、β3-AR蛋白水平明显降低(P〈0.05)。与高脂模型组比较,小剂量组和大剂量组AT1R表达下调,AT2R和β3-AR表达上调(P〈0.05,P〈0.01)。结论β3-AR激动剂在改善apoE-/-老年高脂小鼠血脂代谢紊乱的同时,影响了肺组织β3-AR和ATR各亚型表达,这种受体间交互作用可能与维持高脂血症条件下肺脏的正常功能有关。
简介:目的探讨应用血栓抽吸对行直接经皮冠状动脉介入治疗(PCI)的急性ST段抬高型心肌梗死(STEMI)患者Tp-e及Tp-e/QT的影响.方法选取同期发病12h内行直接PCI罪犯血管(IRA)内存在血栓负荷重的STMEI患者110例,随机分成血栓抽吸组(血栓抽吸+PCI)及对照组(单纯PCI).测量两组PCI术前及术后2h心电图中Tp-e及Tp-e/QT,并观察两组在住院期间发生恶性心律失常的情况.结果两组在性别、年龄、心血管风险因子、症状发作至球囊扩张时间、PCI术前Tp-e及Tp-e/QT等方面比较未见统计学差异(P>0.05).血栓抽吸组PCI术后ST段回落>70%的比率、Tp-e及Tp-e/QT减少的幅度均高于对照组[60.00%比40.00%,(22.66±9.91)ms比(15.89±8.24)ms,0.04±0.03比0.03±0.02,P均<0.05];血栓抽吸组PCI术后Tp-e、Tp-e/QT及术后至出院前发生恶性心律失常的比率均低于对照组[(88.54±13.13)ms比(93.7l±11.00)ms,0.25±0.03比0.26±0.03,16.00%比33.33%,P均<0.05].结论对于冠状动脉内血栓负荷重的急性STEMI患者,直接PCI术时应用血栓抽吸可以更多地减少心室复极离散度指标Tp-e及Tp-e/QT,降低心肌梗死后恶性室性心律失常发生的风险.其原因可能与血栓抽吸有助于更好地恢复微循环再灌注水平有关.
简介:Dearcolleaguesanddistinguishedguests:Onbehalfoftheorganizingcommitteeofthe11thSouthChinaInternationalCongressofCardiology(SCC),itisourdistincthonortoinviteyoutoattendtheSCCCongress,whichisgoingtobeheldon9-12April,2009atDongfangHotel,Guangzhou,China.
简介:TheorganizersofSCCwelcomethesubmissionofabstracts.Submissionscoveringallaspectsofcardiovasculardiseasearewelcome.Allacceptedabstractswillbepublishedinsupplement(s)oftheSouthChinaJournalofCardiology.Theexcellentabstractwillbeselectedforpresentationatthesessiononthe11thSCCandrewarded$1000-$5000.Beawarethatyouracceptedabstract(s)willbepublishedandyourcopyrighttransferredtoSCConpublication.
简介:目的探讨E-Flow血流显像技术对胎儿冠状动脉瘘的诊断价值。方法在胎儿超声心动图检查中除使用常规彩色多普勒外加用了E—Flow血流显像技术,产前诊断冠状动脉瘘5例。使用Alokaod0彩色超声诊断仪,探头频率为3.5~5.0MHz。对二维超声(2D)发现胎儿一侧心房、心室异常增大或冠状动脉增粗的患者,进一步探查冠状动脉。先以彩色多普勒超声(CDFI)获取心腔内异常血流,再以连续多普勒(CW)获取舒张期为主的高速血流频谱.初步证实该异常血流来自于冠状动脉。此时启动E-Flow显像模式追溯该异常血流。结果5例胎儿冠状动脉瘘均出生后经超声证实。其中2例为左冠状动脉右心室瘘、1例为左冠状动脉右心房瘘,1例为右冠状动脉右心房瘘,1例为右冠状动脉右心室瘘。E-Flow显像技术能够敏感地捕捉冠状动脉瘘血流,清晰显示冠状动脉瘘的起源、瘘管的走行以及瘘口的位置、大小,其血流显像优于传统的彩色多普勒。结论应用E-Flow显像技术可以在产前更加准确、快速地诊断胎儿冠状动脉瘘。推荐E—Flow血流显像技术成为胎儿冠状动脉瘘的诊断工具之一。
简介:ObjectivesToinvestigatetheeffectofGαq/11signalingpathwayandATP-sensitivepotassiumchannel(KATPchannel)onischemicpreconditioning(IPC)protectioninrathearts.MethodsTwoseriesofexperimentswereperformedinWistarrathearts.Inthefirstseriesofexperiment,ischemicpreconditioningwasinducedbyleftanteriordescendingocclusion(three,5minepisodesseparatedby5minofreperfusion),ischemia-reperfusioninjurywasinducedby30mincoronaryarteryocclusionfollowedby90minreperfusion.Hemodynamics,infarctsizeandscoresofventriculararrhythmiasweremeasured.TheexpressionofGαq/11proteinintheheartwasmeasuredbyWesternblotanalysisinthesecondseries.ResultsIschemicpreconditioningratsshoweddecreasedinfarctsizeandscoresofventriculararrhythmiavsnon-IPcontrolrats.TheeffectofIPCwassignificantlyattenuatedbyglibenclamide(1mg/kg,ip),anonselectiveKATPchannelinhibitor.IPCcausedasignificantincreaseintheexpressionofGαq/11protein.ConclusionsActivationsofGαq/11signalpathwayandKATPchannelplayedsignificantrolesintheclassicalcardioprotectionofischemicprecon-ditioningratheartandmightbeanimportantmechanismofsignaltransductionpathwayduringtheischemicpreconditioning.
简介:The5thChina-JapanJointHypertensionSymposiumwasheldonNovember6th,2002inGuangdongCardiovascularInstitute,GuangdongProvincialPeople’sHospital,Guangzhou,China.Therewereatotalof96paperspublished(includedspeciallectures,oralpresentations,posters).Almost200cardiologists,whocamefromJapanandChina,attendedthesymposium.
简介:The5thAnnualScientificSessionofCardiologyinSouthChinawasheldfromApril3—7.2003inGuangzhou.Aseminar——“TheFrontlineProblemsandNewViewpointsinCardiologyinRecentTimes”washeldatthesametime.MorethanonethousandcardiologyspecialistscamefromsouthandmiddleChinatoparticipateinthemeetingand135paperswere